Browsing by Author "Max Planck Institute of Biochemistry"

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    Error-Prone Splicing Controlled by the Ubiquitin Relative Hub1
    (2017-08-03) Ramazan Karaduman; Sittinan Chanarat; Boris Pfander; Stefan Jentsch; Max Planck Institute of Biochemistry; Alvotech Biopharmaceuticals; Mahidol University
    © 2017 Elsevier Inc. Accurate pre-mRNA splicing is needed for correct gene expression and relies on faithful splice site recognition. Here, we show that the ubiquitin-like protein Hub1 binds to the DEAD-box helicase Prp5, a key regulator of early spliceosome assembly, and stimulates its ATPase activity thereby enhancing splicing and relaxing fidelity. High Hub1 levels enhance splicing efficiency but also cause missplicing by tolerating suboptimal splice sites and branchpoint sequences. Notably, Prp5 itself is regulated by a Hub1-dependent negative feedback loop. Since Hub1-mediated splicing activation induces cryptic splicing of Prp5, it also represses Prp5 protein levels and thus curbs excessive missplicing. Our findings indicate that Hub1 mediates enhanced, but error-prone splicing, a mechanism that is tightly controlled by a feedback loop of PRP5 cryptic splicing activation.
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    Human Proteinpedia enables sharing of human protein data [4]
    (2008-02-01) Suresh Mathivanan; Mukhtar Ahmed; Natalie G. Ahn; Hainard Alexandre; Ramars Amanchy; Philip C. Andrews; Joel S. Bader; Brian M. Balgley; Marcus Bantscheff; Keiryn L. Bennett; Erik Björling; Blagoy Blagoev; Ron Bose; Samir K. Brahmachari; Alma S. Burlingame; Xosé R. Bustelo; Gerard Cagney; Greg T. Cantin; Helene L. Cardasis; Julio E. Celis; Raghothama Chaerkady; Feixia Chu; Philip A. Cole; Catherine E. Costello; Robert J. Cotter; David Crockett; James P. DeLany; Angelo M. De Marzo; Leroi V. DeSouza; Eric W. Deutsch; Eric Dransfield; Gerard Drewes; Arnaud Droit; Michael J. Dunn; Kojo Elenitoba-Johnson; Rob M. Ewing; Jennifer Van Eyk; Vitor Faca; Jayson Falkner; Xiangming Fang; Catherine Fenselau; Daniel Figeys; Pierre Gagné; Cecilia Gelfi; Kris Gevaert; Jeffrey M. Gimble; Florian Gnad; Renu Goel; Pavel Gromov; Samir M. Hanash; William S. Hancock; H. C. Harsha; Gerald Hart; Faith Hays; Fuchu He; Prashantha Hebbar; Kenny Helsens; Heiko Hermeking; Winston Hide; Karin Hjernø; Denis F. Hochstrasser; Oliver Hofmann; David M. Horn; Ralph H. Hruban; Nieves Ibarrola; Peter James; Ole N. Jensen; Pia Hønnerup Jensen; Peter Jung; Kumaran Kandasamy; Indu Kheterpal; Reiko F. Kikuno; Ulrike Korf; Roman Körner; Bernhard Kuster; Min Seok Kwon; Hyoung Joo Lee; Young Jin Lee; Michael Lefevre; Minna Lehvaslaiho; Pierre Lescuyer; Fredrik Levander; Megan S. Lim; Christian Löbke; Institute of Bioinformatics; Johns Hopkins University; The Johns Hopkins School of Medicine; Kuvempu University; University of Colorado at Boulder; Universite de Geneve Faculte de Medecine; Calibrant Biosystems, Inc.; Cellzome AG; Osterreichische Akademie Der Wissenschaften; AlbaNova University Center; Syddansk Universitet; Institute of Genomics and Integrative Biology India; University of California, San Francisco; CSIC-USAL - Instituto de Biologia Molecular y Celular del Cancer de Salamanca (IBMCC); University College Dublin; Scripps Research Institute; NYU School of Medicine; Dansk Center For Translationel Brystkraeftforskning; Boston University School of Medicine; University of Michigan Medical School; University of Pittsburgh; York University; Institute for Systems Biology; TI Food and Nutrition; Universite Laval; Transition Therapeutics; Infochromics; Johns Hopkins Bayview Medical Center; Fred Hutchinson Cancer Research Center; GenWay Biotech Inc.; University of Maryland; University of Ottawa, Canada; Universita degli Studi di Milano; Department of Biochemistry and Medical Protein Research; Pennington Biomedical Research Center; Max Planck Institute of Biochemistry; Northeastern University; Beijing Institute of Radiation Medicine; Fudan University Shanghai Medical College; University of the Western Cape; Hopitaux universitaires de Geneve; Agilent Technologies; Johns Hopkins Medical Institutions; Lunds Universitet; Kazusa DNA Research Institute; German Cancer Research Center; Yonsei University; University of California, Davis; University of California, Los Angeles; European Bioinformatics Institute; Universitat de Barcelona; University of Michigan, Ann Arbor; Hanover; Hospital for Sick Children University of Toronto; University of Toronto; Ludwig Institute for Cancer Research Melbourne; INRA Centre de Clermont-Ferrand-Theix; North Carolina State University; Riken Research Center for Allergy and Immunology; Institute of Medical Science The University of Tokyo; European Molecular Biology Laboratory Heidelberg; George Mason University; Pacific Northwest National Laboratory; Helsingin Yliopisto; University of Tampere Institute of Medical Technology; David Geffen School of Medicine at UCLA; Centre for Cellular and Molecular Biology india; Mahidol University; SAIC-Frederick; Imperial College London

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