Browsing by Author "Nangola S."

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    Diagnostic performance of procalcitonin and presepsin in sepsis: a systematic review and meta-analysis
    (2025-12-04) Chairaj T.; Mongkhon P.; Leewongsakorn P.; Saensongkwae K.; Nangola S.; Saoin S.; Prompunt E.; Chantharit P.; Kloypan C.; Chairaj T.; Mahidol University
    BACKGROUND: Sepsis is a critical emergency condition characterized by life-threatening organ dysfunction due to a dysregulated response to infection. In the fast-paced emergency department (ED) setting, rapid identification and prompt initiation of treatment within the initial hours following sepsis onset are critical for reducing mortality and improving patient outcomes. However, a timely and accurate diagnosis remains a significant challenge in emergency medicine. Biomarkers such as procalcitonin (PCT) and presepsin (P-SEP) have been proposed as tools to distinguish sepsis from other non-infectious inflammatory conditions frequently encountered in the ED, though their diagnostic effectiveness remains controversial. This study aimed to evaluate the diagnostic performance of PCT and P-SEP for diagnosis patients with sepsis. METHODS: A comprehensive systematic search was conducted across the Cochrane Central Register of Controlled Trials, PubMed, and Scopus databases up to April 1st, 2024 and updated on June 30th, 2025. Studies reporting sensitivity and specificity of PCT and P-SEP for sepsis detection among patients in acute and emergency settings were included. Hierarchical modeling techniques were utilized to pool data for sensitivity, specificity, and area under the receiver operating characteristic curve (AUROC) along with their 95% confidence intervals (CIs). RESULTS: Thirty-eight observational studies met inclusion criteria. The pooled sensitivities and specificities for detecting sepsis using PCT were 0.78 (95% CI: 0.74-0.81) and 0.77 (95% CI: 0.71-0.82), respectively. Similarly, for P-SEP, pooled sensitivity and specificity were 0.82 (95% CI: 0.77-0.86) and 0.78 (95% CI: 0.73-0.83), respectively. No statistically significant differences were identified between PCT and P-SEP regarding sensitivity (p = 0.169) or specificity (p = 0.792). The summary receiver operating characteristic analysis yielded an AUROC of 0.84 (95% CI: 0.81-0.87) for PCT and 0.87 (95% CI: 0.84-0.90) for P-SEP. CONCLUSIONS: Both PCT and P-SEP represent reliable biomarkers for early and accurate sepsis detection in acute and ED settings, demonstrating comparable diagnostic performance. Their integration into routine ED assessment protocols may support timely clinical decision-making and prompt initiation of appropriate treatment strategies.
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    Factors Related to Club Cell Protein 16 (CC16) and Quality of Life in Northern Thailand
    (2023-01-01) Nangola S.; Thongtip S.; Saoin S.; Kloypan C.; Pimonsree S.; Tantrakarnapa K.; Mahidol University
    Exposure to poor air quality can cause adverse health effects, especially club cell protein 16 (CC16) as potential marker for a lung injury, and a reduced quality of life (QoL). This study aimed to evaluate factors related to CC16 and QoL among people living near the air quality monitoring stations in Northern Thailand. A cross-sectional study was conducted. A total of 240 individuals were recruited. Data was collected using structured 36-item short-form survey (SF-36) questionnaires. Air quality was measured using air quality monitoring stations by the Pollution Control Department (PCD), Thailand. Diseases and related health problems were defined using the International Classification of Diseases ICD-10) by the Information and Communication Technology Center, Thailand. Venous blood was collected and analyzed for serum CC16 by medical laboratory technicians. The daily PM10 and PM2.5 concentrations were significantly positively associated with I00-I99 and J00-J99.8. The mean ± SD of serum CC16 levels in participants under 60 years old was 5.33 ± 4.24 ng/ml, which was significantly lower than 10.01 ± 6.91 ng/ml in participants 60 years and older (p value < 0.001). The serum CC16 level was significantly associated with physical health (PH), mental health (MH), and overall QoL. Multiple linear regression analysis showed that an increase in serum CC16 level was associated with a decrease in overall QoL after adjusting for confounding variables. Concerned agencies should provide policymakers and health promotion interventions for reducing pollution exposure and self-protective behaviors to prevent airway inflammatory responses, chronic respiratory diseases, and poor QoL.