Browsing by Author "Peerapan Tan-anya"

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    Pharmacokinetics and ex vivo anti-malarial activity OFsera following a single oral dose of dihydroartemisinin in healthy Thai males
    (1997-12-01) Kesara Na-Bangchang; Kanungnit Congpoung; Ratawan Ubalee; Aurathai Thanavibul; Peerapan Tan-anya; Juntra Karbwang; Mahidol University; Thailand Ministry of Public Health
    The pharmacokinetics of dihydroartemisinin (DHA) was studied in eight healthy male Thai subjects after a single oral dose of 300 mg. Absorption of oral DHA was rapid, Cmax of 679 (307-1000) ng/ ml was observed at 1.5 (1-2.5) hours after dosing [median (range)]. Plasma concentrations declined monoexponentially and at 12 hours after administration, the levels were below the detection limit (3 ng/ml). A large variation in the AUC (approximately) 50% was observed. The median (range) AUC was 2010 (636-4079) ng h/ml. The lag time and absorption half-life (t1.2a) were 0.169 (0.111-0.277) hours and 0.709 (0.367-1.118) hours respectively. t1/2z was 1.25(0.79-1.89) hours Vz/f and CL/f were 5.9 (3.5-8.2) 1/kg and 45.3 (28.6-122.8) ml/min/kg, respectively. The pattern of its ex vivo serum activity coincided with the plasma concentrations of DHA.