Browsing by Author "Phetcha Buri Coastal Aquaculture Research and Development Center"

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    Hexane extract of seaweed caulerpa lentillifera inhibits cell proliferation and induces apoptosis of human glioblastoma cells
    (2021-04-01) Varitta Tanawoot; Pornpun Vivithanaporn; Tanapan Siangcham; Krai Meemon; Nakorn Niamnont; Prasert Sobhon; Montakan Tamtin; Kant Sangpairoj; Faculty of Medicine Ramathibodi Hospital, Mahidol University; Faculty of Medicine, Thammasat University; Mahidol University; Burapha University; King Mongkut's University of Technology Thonburi; Phetcha Buri Coastal Aquaculture Research and Development Center
    Glioblastoma is one the most aggressive types of brain cancers resistant to conventional anti-neoplastic drugs. Marine seaweeds possess valuable bioactive compounds for disease prevention and therapy, including for a number of cancers. Caulerpa lentillifera is a tropical marine seaweed containing various minerals and bioactive ingredients. This study demonstrated the activity of C. lentillifera hexane extract (CLHE) against A172 human glioblastoma cells. The extract exerted growth-inhibitory effects by inhibiting cell proliferation and inducing apoptosis. CLHE also induced ROS accumulation and altered mitochondrial membrane potential in A172 cells. Taken together, CLHE might be a potential anticancer agent for use against glioblastoma.