Browsing by Author "Punyaphat Sirithanabadeekul"

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    Comparison of Fractional Picosecond 1064-nm Laser and Fractional Carbon Dioxide Laser for Treating Atrophic Acne Scars: A Randomized Split-Face Trial
    (2021-02-01) Punyaphat Sirithanabadeekul; Ploypailin Tantrapornpong; Bheeratida Rattakul; Nalinee Sutthipisal; Wilai Thanasarnaksorn; Ramathibodi Hospital; Samitivej Hospital (Sukhumvit); Thammasat University
    BACKGROUND: To date, no studies have compared the fractional picosecond 1064-nm laser (FxPico) and fractional carbon dioxide laser (FxCO2) for the treatment of acne scars. OBJECTIVE: To compare the efficacy and safety between FxPico and FxCO2 for treating facial atrophic acne scars. MATERIALS AND METHODS: Twenty-five Asian patients with mild to moderate atrophic acne scars underwent single sessions of randomized split-face treatment with FxPico and FxCO2. Clinical efficacy was assessed by photographs, skin imaging analysis, and patient satisfaction. The adverse events were recorded on every visit. Skin biopsies were performed immediately and 3 months after treatment. RESULTS: The physician improvement scores for skin texture and atrophy significantly increased on the FxPico sides, but no significant difference was observed between FxPico and FxCO2. Skin imaging also showed significant improvement on both sides for scar volume. Postinflammatory hyperpigmentation (PIH) was not reported on FxPico sides, whereas 6 patients (24%) experienced mild PIH on FxCO2 sides. Immediate post-FxPico skin biopsy revealed laser-induced optical breakdown with photoacoustic columns. Collagen and elastic fibers increased at 3 months after both treatments. CONCLUSION: FxPico was as effective as FxCO2 in treating atrophic acne scars, correlating with evidence of tissue remodeling with more safety profiles.
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    The 'pantie' tumour
    (2014-01-01) Silada Kanokrungsee; Vasanop Vachiramon; Punyaphat Sirithanabadeekul; Mahidol University; Thammasat University
    © 2014 S. Karger AG, Basel. We present a case of radiation-associated angiosarcoma. A 67-year-old Thai woman was diagnosed with endometrium carcinoma stage IC and was treated with surgery and radiations. Ten years later, she presented with a gradually enlarging mass on the pubic area, in the shape of a pair of panties. Skin biopsy of lesions confirmed angiosarcoma. The diagnosis was radiation-associated angiosarcoma. She was treated with chemotherapy due to unresectable tumour. The chemotherapy was started with paclitaxel 70 mg/m2 every 2 weeks. After completing the fifth cycle of paclitaxel, the lesion was markedly decreased in size and the symptoms previously described were also completely resolved.
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    Split face comparison between common concentration vs double dilution of intradermal abobotulinum toxin type A (Dysport) injection for facial lifting in Asians
    (2018-06-01) Punyaphat Sirithanabadeekul; Siripan Lapsomboonsiri; Atiya Rungjang; Wilai Thanasarnaksorn; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; Thammasat University
    © 2018 Wiley Periodicals, Inc. Background: The most efficacious concentration of botulinum toxin for facial lifting is not well established. Objective: This study compared the efficacy of common concentration vs double dilution of intradermal abobotulinum toxin type A (Dysport) injection for facial lifting in Asians. Methods: In all, 10 women aged 32-61 years with mild to moderate facial laxity participated in this study. Each patient received one session of intradermal injection of double diluted abobotulinum toxin type A (Dysport) (dilution of 15 mL to give 3.33 units per 0.1 mL) on one side of the face and common concentration (dilution of 7.5 mL to give 6.67 units per 0.1 mL) on the opposite side of the face. Clinical improvement of facial lifting, wrinkling, and subjective satisfaction was evaluated at every visit (baseline, 2, 4, 8, and 12 weeks). Results: Both concentrations offered reduction of facial laxity and wrinkles, with no statistical difference. The effects gradually increased and lasted for a minimum 12 weeks with both concentrations. Conclusion: Common concentration and double dilution of intradermal abobotulinum toxin type A (Dysport) injection were effective and safe for facial lifting in Asians. There were no statistically significant differences between the two concentrations.
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    Treatment of melasma in men with low-fluence Q-Switched neodymium-doped yttrium-aluminum-garnet laser versus combined laser and glycolic acid peeling
    (2015-01-01) Vasanop Vachiramon; Sinijchaya Sahawatwong; Punyaphat Sirithanabadeekul; Mahidol University; Thammasat University
    © 2015 by the American Society for Dermatologic Surgery, Inc. BACKGROUND Low-fluence Q-switched neodymium-doped yttrium-aluminum-garnet 1,064-nm laser (LFQS) and glycolic acid (GA) peeling have been reported as a treatment option for melasma. However, there are limited data on their efficacy in men. OBJECTIVE To compare the efficacy and safety of LFQS monotherapy with combined LFQS and 30% GA peeling in male patients with melasma. MATERIALS AND METHODS Fifteen males with mixed type melasma were randomized to receive 5 weekly sessions of LFQS on one side of the face and LFQS plus 30% GA peeling on the contralateral side and were followed for 12 weeks. Twelve patients completed the protocol. RESULTS Mean relative lightness index (RL∗I) of the combined treatment side was lowered throughout the study period, with the maximal improvement of 52.3% reduction at the fourth week follow-up (p = .023). Patient selfassessment was favorable in the combined treatment. However, the mean RL∗I increased at 8 and 12 weeks of follow-up. One subject (8.3%) developed guttate hypopigmentation, which did not resolve by the 12-week follow-up. CONCLUSION Low-fluence Q-switched neodymium-doped yttrium-aluminum-garnet 1,064-nm laser combined with GA peeling temporarily reduced melasma in men, but the incidence of side effects does not justify the short-lived benefits of this procedure. This technique requires further study.