Browsing by Author "Saisongcroh T."

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    Deep vein thrombosis screening in pediatric orthopedic patients
    (2023-01-01) Tongta S.; Angsnuntsukh C.; Saisongcroh T.; Woratanarat T.; Tangsopa Y.; Woratanarat P.; Mahidol University
    Background: Deep vein thrombosis (DVT) is an important clinical condition that leads to subsequent morbidity and mortality in children, particularly those who involved operative procedures. The preoperative assessment for DVT in children may vary among different population risk factors and types of surgery. This study aimed to evaluate the screening methods for DVT in pediatric orthopedic patients. Method: We performed a retrospective cohort study of orthopedic patients aged <18 years at Ramathibodi Hospital, Bangkok, Thailand, from 2015 to 2019. The inclusion criteria were children scheduled for orthopedic surgery; who performed a D-dimer test, Wells score, and Caprini score; and who underwent Doppler ultrasonography for DVT screening. The exclusion criteria were incomplete data or inconclusive ultrasonographic results. Age and results of the D-dimer test, Wells score, and Caprini score were collected from all patients. The outcome assessment was ultrasound-proven DVT. The screening abilities of each test were analyzed in terms of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), likelihood ratio (LR) for positive and negative tests, and area under the receiver operating characteristic curve (AUC). Results: A total of 419 children were included in the study. Five (1.19%) patients were diagnosed with DVT. The mean age was 10.16 ± 4.83 years. D-dimer ≥500 ng/mL had a sensitivity of 100% (95% CI: 47.8%–100%), a specificity of 36.7% (95% CI: 32.1%–41.6%), a PPV of 1.9% (95% CI: 0.6%–4.3%), and an NPV of 100% (95% CI: 97.6%–100%). Wells score ≥3 demonstrated a sensitivity of 0% (95% CI: 0%–52.2%), a specificity of 99.3% (95% CI: 97.9%–99.9%), and an LR for a negative test of 1.00 (95% CI: 1.00–1.01). Caprini score ≥11 had a sensitivity of 0% (95% CI: 0%–52.2%) and a specificity of 99.8% (95% CI: 98.7%–100%). The parallel test included D-dimer ≥500 ng/mL, Wells score ≥3, or Caprini score ≥11 points, generating a sensitivity of 100% (95% CI: 47.8%–100%), a specificity of 36.7% (95% CI: 32.1%–41.6%), an LR for a positive test of 1.58 (95% CI: 1.47–1.70), and an AUC of 0.68 (95% CI: 0.66–0.71). Conclusions: The D-dimer test exhibited moderate ability in predicting the development of DVT among pediatric orthopedic patients requiring surgery. The Wells score and Caprini score had low performance in identifying hospitalized children at increased risk of DVT events.
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    Factors for selective ultrasound screening in newborns with developmental dysplasia of the hip (DDH)
    (2022-10-24) Angsanuntsukh C.; Patathong T.; Klaewkasikum K.; Jungtheerapanich W.; Saisongcroh T.; Mulpruek P.; Woratanarat P.; Mahidol University
    Background: Hip ultrasound screening for DDH provides better sensitivity compared to physical examination. Due to a lower prevalence and limited resources, selective hip ultrasound in newborns at risk could be considered a proper screening protocol in Thailand and Asian countries. Objective: This study was aimed to evaluate risk factors and define criteria for selective screening. Methods: A case-control study was conducted in 2020. All newborns with hip ultrasound screening were included. Cases were defined as newborns with abnormal hip ultrasounds, while controls were those with normal studies. Inter and intra-rater reliability were evaluated. All factors were analyzed using univariate and multivariate logistic regression. The model performance was tested by Hosmer-Lemeshow goodness of fit. Internal validity was performed by the split data method. Area under the receiver operating characteristic (ROC) curve was estimated. Results: Ninety-five newborns (29 cases and 66 controls) were included. Eighty percent of cases and 58% of controls were female. The gestational age was 36.6 and 37.7 weeks in case and control, respectively. Female, breech presentation, positive Ortolani test, positive Barlow test, and limited hip abduction were significant factors with odds ratio of 2.82, 5.12, 34.21, 69.64, and 5.48, respectively. The final model included breech presentation, positive Ortolani test, and positive Barlow test. The model cut-off value 15.02 provided sensitivity (93.10%) and specificity were (80.30%). The area under the ROC curve was 0.9308. The split data remained significant internal validity for all factors with p-value < 0.05. Conclusion: Careful history taking and physical examination are essential to identify the risk factors for DDH. Newborns with breech presentation, positive Ortolani test and positive Barlow test should be screened by hip ultrasound.