Browsing by Author "Scott D. Nelson"

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    Ewing sarcoma in a patient with Cowden syndrome
    (2015-11-01) Mod C. Chandhanayingyong; Nicholas M. Bernthal; Piti Ungarreevittaya; Scott D. Nelson; Sant P. Chawla; Arun S. Singh; David Geffen School of Medicine at UCLA; Mahidol University; Khon Kaen University; Sarcoma Oncology Center
    © JNCCN-Journal of the National Comprehensive Cancer Network. A 47-year-old woman, initially diagnosed in 1996 with Cowden syndrome (CS), PTEN-mutant bilateral breast cancer, a thyroid nodule, and uterine fibroids, presented to UCLA in 2013 with Ewing sarcoma of the pelvic bone. Her treatment course included mastectomies, hysterectomy/ oophorectomy, and total thyroid resection, and chemotherapy, radiation, and hemipelvectomy for Ewing sarcoma. This case report illustrates the unusual presentation of Ewing sarcoma in a patient with PTEN-mutant CS, the probable underlying molecular pathogenesis, long-term management, and therapeutic considerations.