Browsing by Author "Somprasong S."

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    Direct Synthesis of Coumarin Derivatives from Alkynoic Esters via Dual Organocatalysis
    (2022-09-01) Saejong P.; Somprasong S.; Rujirasereesakul C.; Luanphaisarnnont T.; Mahidol University
    An efficient synthetic method for coumarin derivatives was developed using a dual organocatalytic reaction. A combination of ptoluenesulfonic acid monohydrate and piperidine was found to efficiently catalyze the cyclization between salicylaldehydes and alkynoic esters to give various coumarin derivatives in good yield and high selectivity. Mechanistic and kinetic data suggested that the conjugate addition between piperidine and alkynoic esters played a crucial role in the reaction mechanism.
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    Initial Development and Validation of Physical Therapy-Patient Education Questionnaire (PT-PEQ)
    (2024-06-01) Hengsomboon N.; Kunanusornchai W.; Sakulsriprasert P.; Hengsomboon P.; Somprasong S.; Sakuna M.; Pipatkasira P.; Intiravoranont W.; Sathianpantarit P.; Jensen M.P.; Hengsomboon N.; Mahidol University
    BACKGROUND: Patient education can increase patient engagement and positive outcomes with physical therapy treatment. This study aimed to develop and evaluate the psychometric properties of a physical therapy patient education questionnaire. METHODS: Candidate items were developed and evaluated by an expert panel for content validity. The resulting items were administered to 350 patients in physical therapy treatment, and the reliability and validity of the scale's subscales were evaluated. RESULTS: The final version of the questionnaire consists of 36 items that assess six education domains for patients receiving physical therapy: 1) assessment and information provision (10 items), 2) hygiene and safety (9 items), 3) patient empowerment (8 items), 4) emergency and infection control (3 items), 5) adverse event prevention (4 items), and 6) identity confirmation (2 items). The internal consistency of the subscales ranged from 0.69 to 0.92, and support for the six-domain structure of the items was supported via factor analysis. CONCLUSIONS: The questionnaire was successfully developed and evidenced good psychometric properties for the assessment of the perceived importance of six physical therapy education domains. Research is needed to evaluate potential gaps between patients' perceived education needs and therapist education activities during physical therapy treatment.
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    Reliability and concurrent validity of the bubble inclinometer for visual estimation of straight leg raise in asymptomatic individuals
    (2024-01-01) Somprasong S.; Sakulsriprasert P.; Vachalathiti R.; Kingcha P.; Janyathitipath T.; Somprasong S.; Mahidol University
    Introduction. The straight leg raise (SLR) test is commonly used to investigate neurodynamic problems or hamstring muscle length. Visual estimation can be used to identify the degrees of hip flexion during the SLR test. However, intra-tester and intertester reliability, as well as concurrent validity, await formal investigation. Methods. This study was an experimental study. Two testers, a novice and an experienced physical therapist, measured hip flexion angles during the SLR test using visual estimation for two sessions and the bubble inclinometer method during the first session in 31 asymptomatic participants, in random order. Intra-tester reliability (intraclass correlation coefficient, ICC3,3), intertester reliability (ICC2,3), concurrent validity (Pearson correlation with bubble inclinometer), and measurement error was represented as standard error of measurement (SEM) and minimal detectable change (MDC), were calculated. Results. The concurrent validity and intra-tester reliability of visual estimation for both testers were good (ICC3,3 = 0.885 with 95% confidence interval = 0.775–0.943, p < 0.001) and excellent (ICC3,3 = 0.904 with 95% confidence interval = 0.810–0.952, p < 0.001), respectively. Inter-tester reliability of visual estimation was poor (ICC2,3 = 0.373 with 95% confidence interval = 0.027–0.639, p = 0.018). Conclusions. Although the concurrent validity of visual estimation with the bubble inclinometer was good, and intra-tester reliability was excellent, the inter-tester reliability was poor. Therefore, caution should be exercised if more than one tester is involved in visual estimation.
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    Sulfonic-acid functionalized hypercrosslinked porous organic polymer as a highly efficient heterogeneous catalyst for synthesis of 2H-chromene derivatives
    (2026-01-01) Somprasong S.; Ratvijitvech T.; Tiyawarakul T.; Rujirasereesakul C.; Sitthasakul T.; Luanphaisarnnont T.; Somprasong S.; Mahidol University
    A sulfonic acid-functionalized hypercrosslinked porous organic polymer (HCP-H-SO3H) with high surface area (SBET = 604 m2 g−1) was successfully synthesized via a Friedel–Crafts alkylation of benzene and dimethoxymethane, followed by sulfonation of aromatic rings using sulfuric acid. This material was used as an efficient heterogeneous catalyst in a cyclization between various ortho-hydroxy aromatic aldehydes and acetylenic diesters, affording the corresponding 2H-chromenes in moderate to excellent yields. The material could be reused for at least five reaction cycles, suggesting the sustainable application potential of this sulfonic-acid functionalized materials as a heterogeneous acid catalyst. A mechanistic investigation using 13C NMR kinetic isotope effect at natural abundance experiments provided insights into a similar nature of the rate-limiting steps in the catalytic processes of the homogeneous catalyst (p-toluenesulfonic acid monohydrate; PTSA·H2O) and the heterogeneous catalyst (HCP-H-SO3H).