Browsing by Author "Subhabrata Chakrabarti"

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    The association between complement component 2/complement factor B polymorphisms and age-related macular degeneration: A HuGE review and meta-analysis
    (2012-09-01) Ammarin Thakkinstian; Mark McEvoy; Usha Chakravarthy; Subhabrata Chakrabarti; Gareth J. McKay; Euijung Ryu; Giuliana Silvestri; Inderjeet Kaur; Peter Francis; Takeshi Iwata; Masakazu Akahori; Astrid Arning; Albert O. Edwards; Johanna M. Seddon; John Attia; Mahidol University; University of Newcastle, Australia; Queen's University Belfast; L.V. Prasad Eye Institute India; Mayo Clinic; OHSU School of Medicine; National Hospital Organization, Japan; Leibniz Institute of Arteriosclerosis Research; University of Oregon; Tufts University School of Medicine; John Hunter Hospital
    The authors performed a systematic review of the association of complement component 2(C2)/complement factor B (CFB) gene polymorphisms with age-related macular degeneration (AMD). In total, data from 19 studies published between 2006 and 2011 were pooled for 4 polymorphisms: rs9332739 and rs547154 in the C2 gene and rs4151667 and rs641153 in the CFB gene. Data extraction and assessments for risk of bias were independently performed by 2 reviewers. Allele frequencies and allele and genotypic effects were pooled. Heterogeneity and publication bias were explored. Pooled minor allele frequencies for all 4 SNPs were between 4.7 and 9.6 for all polymorphisms, except for an Indian population in which the C allele at rs9332739 was the major allele. For the C2 polymorphisms, the minor C allele at rs9332739 and the minor T allele at rs547154 carried estimated relative risks (odds ratios) of 0.55 (95 confidence interval (CI): 0.46, 0.65) and 0.47 (95 CI: 0.39, 0.57), respectively. For the CFB polymorphisms, the minor A alleles at rs4151667 and rs614153 carried estimated risks of 0.54 (95 CI: 0.45, 0.64) and 0.41 (95 CI: 0.34, 0.51), respectively. These allele effects contributed to an absolute lowering of the risk of all AMD in Caucasian populations by 2.06.0. This meta-analysis provides a robust estimate of the protective association of C2/CFB with AMD. © 2012 The Author.
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    Systematic review and meta-analysis of the association between complement component 3 and age-related macular degeneration: A HuGE review and meta-analysis
    (2011-06-15) Ammarin Thakkinstian; Gareth J. McKay; Mark McEvoy; Usha Chakravarthy; Subhabrata Chakrabarti; Giuliana Silvestri; Inderjeet Kaur; Xiaoxin Li; John Attia; Mahidol University; Queen's University Belfast; University of Newcastle, Australia; L.V. Prasad Eye Institute India; Peking University; Hunter Medical Research Institute, Australia; John Hunter Hospital
    The authors performed a meta-analysis to estimate the magnitude of polymorphism effects for the complement component C3 gene (C3) and their possible mode of action on age-related macular degeneration (AMD). The meta-analysis included 16 and 7 studies for rs2230199 and rs1047286, respectively. Data extraction and risk of bias assessments were performed in duplicate, and heterogeneity and publication bias were explored. There was moderate evidence for association between both polymorphisms and AMD in Caucasians. For rs2230199, patients with CG and GG genotypes were 1.44 (95% confidence interval (CI): 1.33, 1.56) and 1.88 (95% CI: 1.59, 2.23) times more likely to have AMD than patients with the CC genotype. For rs1047286, GA and AA genotypes had 1.27 (95% CI: 1.15, 1.41) and 1.70 (95% CI: 1.27, 2.11) times higher risk of AMD than did GG genotypes. These gene effects suggested an additive model. The population attributable risks for the GG/GC and AA/GA genotypes are approximately 5%-10%. Subgroup analysis by ethnicity indicates that these variants are very infrequent in Asians and that the observed gene effects are based largely on the high frequency within Caucasian populations. This meta-analysis supports the association between C3 and AMD and provides a robust estimate of the genetic risk. © 2011 The Author.