Browsing by Author "Terence C.W. Poon"

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    Chromosome-centric human proteome project (C-HPP): Chromosome 12
    (2014-07-03) Sakdithep Chaiyarit; Nilubon Singhto; Yi Ju Chen; Chia Ying Cheng; Wararat Chiangjong; Rattiyaporn Kanlaya; Henry H.N. Lam; Paleerath Peerapen; Ting Yi Sung; Phornpimon Tipthara; Akhilesh Pandey; Terence C.W. Poon; Yu Ju Chen; Ravi Sirdeshmukh; Maxey C.M. Chung; Visith Thongboonkerd; Mahidol University; Institute of Chemistry Academia Sinica Taiwan; Institute of Information Science Academia Sinica Taiwan; Hong Kong University of Science and Technology; Institute of Bioinformatics; The Johns Hopkins School of Medicine; Prince of Wales Hospital Hong Kong; National University of Singapore; Yong Loo Lin School of Medicine
    Following an official announcement of the Chromosome-centric Human Proteome Project (C-HPP), the Chromosome 12 (Ch12) Consortium has been established by five representative teams from five Asian countries including Thailand (Siriraj Hospital, Mahidol University), Singapore (National University of Singapore), Taiwan (Academia Sinica), Hong Kong (The Chinese University of Hong Kong), and India (Institute of Bioinformatics). We have worked closely together to extensively and systematically analyze all missing and known proteins encoded by Ch12 for their tissue/cellular/subcellular localizations. The target organs/tissues/cells include kidney, brain, gastrointestinal tissues, blood/immune cells, and stem cells. In the later phase, post-translational modifications and functional significance of Ch12-encoded proteins as well as their associations with human diseases (i.e., immune diseases, metabolic disorders, and cancers) will be defined. We have collaborated with other chromosome teams, Human Kidney and Urine Proteome Project (HKUPP), AOHUPO Membrane Proteomics Initiative, and other existing HUPO initiatives in the Biology/Disease-Based Human Proteome Project (B/D-HPP) to delineate functional roles and medical implications of Ch12-encoded proteins. The data set to be obtained from this multicountry consortium will be an important piece of the jigsaw puzzle to fulfill the missions and goals of the C-HPP and the global Human Proteome Project (HPP). © 2014 American Chemical Society.