Journal Issue: JAAS Vol. 6 No. 2
Issued Date
2556
Resource Type
Language
tha
eng
eng
File Type
application/pdf
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
คณะสัตวแพทยศาสตร์ มหาวิทยาลัยมหิดล
Journal Volume
JAAS Volume 6
(2566)
Articles
Effects of alcoholic extract from pomegranate (Punica granatum L.) peels on gastrointestinal nematode egg counts in doe
(2013) Sookruetai Boonmasawai; Sivapong Sungpradit; Charoonluk Jirapattharasate; Chowalit Nakthong; Lak Piasai; Mahidol University. Faculty of Veterinary Science
Anthelmintic drug resistant is one of the major problem that quietly reflecting the small ruminant
production qualities. Because this problem recently spread out in many areas all over the world, the alternative
anthelmintic methods are recently requiring, especially using local economic plants or remedies for reducing the
impact. The pomegranate (Punica granatum L.) is one kind of fruit that is used as an anthelmintic plant in Ayurveda
remedies for a long time. We investigated the anthelmintic activity of alcoholic extract from pomegranate peels
against female goat gastrointestinal nematodes and the toxic effects after treatments. The results were shown
that albendazole and pomegranate peel powder could not affect percent of strongyle egg per gram (EPG) when
comparing with pre-treatment control data. In contrast, ivermectin injections could significantly affect a first
24h (32 ± 5%), and had continuously effect at day 3, 7 and 14 (31 ± 17%, 51 ± 13% and 33 ± 11%, respectively).
Alcoholic extract of pomegranate represented significantly anthelmintic effects at day 1, 3 and 7 (45 ± 11%,
57 ± 14% and 64 ± 7%, respectively) with non-significantly different when comparing with ivermectin. We also
preliminary investigated the effects of alcoholic extract from mangosteen (Garcinia mangostana) peels, it could not
effect on egg count number per gram when comparing with pre-treatment control. The results suggested that
alcoholic crude extracts from pomegranate peels could inhibit gastrointestinal strongyle-type egg production
and may be promising used as an alternative anthelmintic drugs in small ruminant farms.
Anthelmintic effects of ethanolic extracts from pomegranate peels, mangosteen peels and tamarind seeds on gastrointestinal nematode egg counts in lambs
(2013) Pichai Bunviboolvat; Narisa Taechaarpornkul; Jeerapha Saratham; Sivapong Sungpradit; Charoonluk Jirapattharasate; Chowalit Nakthong; Lak Piasai; Orathai Thongjui; Sookruetai Boonmasawai; Mahidol University. Faculty of Veterinary Science
The anthelmintic drug resistance problems in animal husbandry are widely spread all over the world.
The gastrointestinal nematodes in sheep economically impact on the decreasing of live-weight gain and body
condition scores and have been recently resistant to many anthelmintics, especially albendazole, levamisole,
macrocyclic lactone, moxidectin and ivermectin. Therefore, the herbal medicine is the one of alternative
anthelmintic ways to solve chemical resistance and economic problems in small ruminant farms. This study
was aimed to investigate the effects of pomegranate (Punica granatum L.) peels, mangosteen (Garcinia mangostana)
peels and tamarind (Tamarindus indica) seeds extracts on gastrointestinal nematode egg counts in lambs
comparing with albendazole and ivermectin. The results were shown that ivermectin could not decrease egg
counted number significantly, but albendazole could significantly decrease percent of the egg per gram
(EPG) when compared with pre-treatment (day 0) at day 1 (68±9%), day 3 (53±10%) and day 7 (62±8%). At
day 1, the ethanolic extract of pomegranate peels and tamarind seed were significantly effect on gastrointestinal
nematode egg count (47±8% and 48±10%, respectively). EPG were not affected by mangosteen peels extract.
Serum alanine aminotransferase (ALT) (8-17.8 IU/L), aspartate aminotransferase (AST) (88.5-127.3 IU/L),
creatinine (0.7-0.9 mg/dl) and blood urea nitrogen (BUN) (11-18.5 mg/dl) value after treatment were also
normal and the lambs did not express any clinical renal or hepatic symptoms. It is concluded that the ethanolic
extracts of pomegranate peels, and tamarind seeds possess significant anthelmintic activities at day 1 and could
be a potential alternative for management of gastrointestinal roundworm problem in lambs.
Title
JAAS Vol. 6 No. 2
Author's Affiliation
มหาวิทยาลัยมหิดล. คณะสัตวแพทยศาสตร์