Publication:
6,7,14,15-Tetrahydro-15aH-azocino[1,2-a:6,5-b']diindole.Synthesis of a novel pentacyclic ring system

Accepted Date

2003-07-24

Issued Date

2003

Resource Type

Original Article

Language

eng

File Type

application/pdf

No. of Pages/File Size

140273 bytes

ISSN

0040-4039

DOI

10.1016/S0040-4039(03)01796-9

Rights

Mahidol University

Rights Holder(s)

Pergamon (available from ScienceDirect)

Bibliographic Citation

Tetrahedron Letters. Vol.44, No.38 (2003),7183-6.

Suggested Citation

Kittisak Sripha, Zlotos, Darius P., Buller, Stefan, Mohr, Klaus 6,7,14,15-Tetrahydro-15aH-azocino[1,2-a:6,5-b']diindole.Synthesis of a novel pentacyclic ring system. Tetrahedron Letters. Vol.44, No.38 (2003),7183-6.. doi:10.1016/S0040-4039(03)01796-9 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/62090

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Title

6,7,14,15-Tetrahydro-15aH-azocino[1,2-a:6,5-b']diindole.Synthesis of a novel pentacyclic ring system

Author(s)

Kittisak Sripha
 Zlotos, Darius P.
 Buller, Stefan
 Mohr, Klaus

Other Contributor(s)

Mahidol University. Faculty of Pharmacy. Department of Pharmaceutical Chemistry.
 University of Wurzburg. Pharmaceutical Institute.

Abstract

In search of new lead structures for potent allosteric enhancers of antagonist binding to muscarinic M2 receptors, a novel heterocyclic ring system, 6,7,14,15-tetrahydro-15aH-azocino[1,2-a:6,5-b′]diindole, has been synthesized. The new ring skeleton was obtained from indol-2-yl-acetic acid in three steps.

Keyword(s)

6,7,14,15-tetrahydro-15aH-azocino[1,2-a:6,5-a']diindole
 novel pentacyclic ring system
 Strychnos alkaloid caracurine V
 dimerization of 2-(indol-2-yl)-ethyl tosylate

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URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/62090

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PY-Article