Publication:
Docking study on phthalimide derivatives : HIV-1 reverse transcriptase inhibitors

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py-ar-jiraporn-2000.pdf (2.34 MB)

Issued Date

2000

Resource Type

Research Article

Language

eng

File Type

application/pdf

No. of Pages/File Size

2396 KB

ISSN

0859-6255

Rights

Mahidol University

Rights Holder(s)

Srinakharinwirot University. Faculty of Pharmacy

Bibliographic Citation

Srinakharinwirot Journal of Pharmaceutical Sciences. 2000;Vol.5, No.1 (2000), 19-27.

Suggested Citation

Jiraporn Ungwitayatorn, Pathanakarn Sothipatcharasai, จิรภรณ์ อังวิทยาธร Docking study on phthalimide derivatives : HIV-1 reverse transcriptase inhibitors. Srinakharinwirot Journal of Pharmaceutical Sciences. 2000;Vol.5, No.1 (2000), 19-27.. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/62272

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Title

Docking study on phthalimide derivatives : HIV-1 reverse transcriptase inhibitors

Author(s)

Jiraporn Ungwitayatorn
 Pathanakarn Sothipatcharasai
 จิรภรณ์ อังวิทยาธร

Corresponding Author(s)

Jiraporn Ungwitayatorn

Other Contributor(s)

Mahidol University. Faculty of Pharmacy. Department of Pharmaceutical Chemistry

Abstract

A docking study of non-nucleoside HIV-1 reverse transcriptase inhibitors in phthalimide series was carried out using FlexiDock option to determine the bound conformation. The results obtained were consistent with the common three-dimensional model proposed by Schafer et al. The bound conformation of the most active compound in this series was aligned in the butterfly-like shape in the same manner as nevirapine.

Keyword(s)

Phthalimide Derivatives
 HIV-1 Reverse Transcriptase Inhibitors

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/62272

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PY-Article