Publication: Effect of acidic medium on swelling and release behavior of chitosan-reinforced calcium pectinate get beads
Issued Date
2008
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Language
eng
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application/pdf
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232691 bytes
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Mahidol University
Bibliographic Citation
Silpakorn University Science and Technology Journal. Vol. 2, No. 1 (2008), 37-44.
Suggested Citation
Pornsak Sriamornsak, พรศักดิ์ ศรีอมรศักดิ์, Kanokporn Burapapat, กนกพร บูรพาพัธ, Nartaya Thirawong, นาตยา ถีระวงษ์, Jurairat Numthanid, จุไรรัตน์ นันทานิช, Satit Puttipipatkhachorn, สาธิต พุทธิพิพัฒน์ขจร Effect of acidic medium on swelling and release behavior of chitosan-reinforced calcium pectinate get beads. Silpakorn University Science and Technology Journal. Vol. 2, No. 1 (2008), 37-44.. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/62076
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Title
Effect of acidic medium on swelling and release behavior of chitosan-reinforced calcium pectinate get beads
Alternative Title(s)
ผลของตัวกลางที่เป็นกรดต่อการพองตัวและการปลดปล่อยยาของแคลเซียมเพคติเนตเจลบีดเสริมความแข็งแรงด้วยไคโตซาน
Abstract
Chitosan-reinforced calcium pectinate (ChCP) gel beads were prepared by ionotropic gelation method. The
swelling of ChCP gel beads and release behavior of indomethacin from the beads were investigated and compared
with conventional calcium pectinate (CP) gel beads. The factors, such as molecular weight of chitosan,
concentration of chitosan, and release medium, which can have a significant effect on the swelling and release
behaviors from the beads, were discussed in this study. The mechanical test showed that the ChCP beads have
slightly higher strength than that of CP beads. The swelling index of the ChCP beads in acidic medium was much
lower than that in neutral medium. The release of indomethacin from ChCP beads under conditions mimicking
intestinal transit were evaluated in pH 7.4 Tris buffer. The acid pretreatment caused a faster drug release from
ChCP beads. The less swelling in acidic medium and faster drug release of acid-pretreated ChCP beads may be
due to the dissolution of chitosan from the beads in acidic medium, as no fluorescence signal was seen at the shell
of the beads. The results suggested that the acid, which essentially found in stomach, influenced the swelling and
release behaviors of ChCP beads.