Publication: Facile p-toluenesulfonic acid-promoted para-selective monobromination and chlorination of phenol and analogues
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2015-07-23
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eng
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Mahidol University
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ScienceDirect
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Tetrahedron. Vol.66, No. 34 (2010), 6928-6935
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Pakorn Bovonsombat, Rameez Ali, Chiraphorn Khan, Juthamard Leykajarakul, Kawin Pla-on, Suraj Aphimanchindakul, Natchapon Pungcharoenpong, Nisit Timsuea, Anchalee Arunrat, Napat Punpongjareorn Facile p-toluenesulfonic acid-promoted para-selective monobromination and chlorination of phenol and analogues. Tetrahedron. Vol.66, No. 34 (2010), 6928-6935. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/10952
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Facile p-toluenesulfonic acid-promoted para-selective monobromination and chlorination of phenol and analogues
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Para-Regioselective bromination of phenol and analogues, promoted by ptoluenesulfonic acid, is achieved in high to excellent yields at room tempature with N-bromosuccinimide. Chlorination with N-chlorosuccinimide and catalysed by p-toluenesulfonic acid also gives para-chlorinated phenol analogues in good yields at room tempature. Para-Bromination of phenol, promoted by p-toluenesulfonic acid, is achieved in excellent yields at room tempature with N-bromosuccinimide. p-Toluenesulfonic acid is also effective as a promoter of para-chlorination with N-chlorosuccinimide.