Publication: Economic burden of rotavirus diarrhea in Thailand: Report from a pilot study on rotavirus vaccination
Issued Date
2019
Resource Type
Language
eng
File Type
video/youtube
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Mahidol University
Rights Holder(s)
Elsevier
Bibliographic Citation
Vaccine. Vol 37, (2019), 587–594
Suggested Citation
Onwipa Rochanathimoke, Arthorn Riewpaiboon, Piyanit Tharmaphornpilas, Suchada Jiamsiri, Montarat Thavorncharoensap, Postma, Maarten J. Economic burden of rotavirus diarrhea in Thailand: Report from a pilot study on rotavirus vaccination. Vaccine. Vol 37, (2019), 587–594. doi:https://doi.org/10.1016/j.vaccine.2018.12.013 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/79488
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Title
Economic burden of rotavirus diarrhea in Thailand: Report from a pilot study on rotavirus vaccination
Other Contributor(s)
Mahidol University. Faculty of Pharmacy. Division of Social and Administrative Pharmacy
Ministry of Public Health. Department of Disease Control
Groningen Research Institute of Pharmacy (GRIP). University of Groningen. Unit of PharmacoTherapy, -Epidemiology & -Economics
University Medical Center Groningen. University of Groningen. Department of Health Sciences
University of Groningen. Faculty of Economics & Business. Department of Economics, Econometrics & Finance
Ministry of Public Health. Department of Disease Control
Groningen Research Institute of Pharmacy (GRIP). University of Groningen. Unit of PharmacoTherapy, -Epidemiology & -Economics
University Medical Center Groningen. University of Groningen. Department of Health Sciences
University of Groningen. Faculty of Economics & Business. Department of Economics, Econometrics & Finance
Abstract
Background: Rotavirus diarrhea is the leading cause of morbidity and mortality in young children in both
developed and developing countries. Hospitalization costs are a significant burden of both governments
and households. The objective of this study was to estimate the economic burden associated with the
hospitalization of children with non-rotavirus and rotavirus diarrhea in two provinces in Thailand.
Method: A prospective incidence-based cost-of-illness study was conducted on children under five years
old with acute diarrhea who had been admitted to public hospitals in two provinces during October 2012
and June 2013. Caregivers were interviewed to estimate costs from a societal perspective at 2014 values.
Stool samples were examined for rotavirus antigens. Multivariate regression analysis was used to assess
the relationship of predictor variables to costs. Annual economic burden of rotavirus hospitalization was
estimated by multiplying the number of hospitalized children and the hospitalization cost per episode.
The costs were converted to international dollars (I$) using purchasing power parity (PPP)
(1 USD = 12.36 baht for the year 2014).
Results: Seven hundred and eighty-eight cases of acute diarrhea were included in the analysis. Of the
total, one hundred and ninety-seven (25%) were detected as being rotavirus positive. Total societal costs
of inpatient care per episode were 822.68 USD (10,165 Baht). The average costs of children with and
without rotavirus were 903.39 USD (11,162 Baht) and 795.40 USD (9,827 Baht), respectively. Based on
the multiple regression analysis, rotavirus infection, severity, and younger age were significantly
associated with the higher costs.
Conclusion: Diarrhea, rotavirus diarrhea in particular, represents of a substantial economic burden in the
society in Thailand. The accurate estimates that societal costs of the rotavirus diarrhea hospitalizations
provide valuable input for considering a preventive program.