Publication: Anticholinesterase of essential oils and their constituents from Thai medicinal plants on purified and cellular enzymes
Issued Date
2012
Resource Type
Language
eng
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application/pdf
No. of Pages/File Size
221.16 KB
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Mahidol University
Rights Holder(s)
Asian Association of Schools of Pharmacy
Bibliographic Citation
Journal of Asian Association of Schools of Pharmacy. Vol.1, No. 1 (2012), 58-67.
Suggested Citation
Worawan Kitphati, Kittima Wattanakamolkul, Pattamapan Lomarat, Phanida Phanthong, Natthinee Anantachoke, Veena Nukoolkarn, Krit Thirapanmethee, Nuntavan Bunyapraphatsara, วรวรรณ กิจผาติ, กิตติมา วัฒนากมลกุล, พนิดา พานทอง, ณัฏฐินี อนันตโชค, วีณา นุกูลการ, กฤษณ์ ถิระพันธุ์เมธี, นันทวัน บุณยะประภัศร Anticholinesterase of essential oils and their constituents from Thai medicinal plants on purified and cellular enzymes. Journal of Asian Association of Schools of Pharmacy. Vol.1, No. 1 (2012), 58-67.. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/62718
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Title
Anticholinesterase of essential oils and their constituents from Thai medicinal plants on purified and cellular enzymes
Corresponding Author(s)
Abstract
Essential oils have the strong potency to inhibit acetylcholinesterase (AChE) in brain because of their lipophilicity and small molecular size constituents. The anticho-linesterase activity of 13 essential oils from Thai medicinal plants was primarily evaluated using purified AChE from eel. Results revealed 6 of them including those from turmeric, galangal, fingerroot, plai, betel vine and holy basil showed such activity. However, only essential oils from turmeric, galangal and fingerroot exhibited the appreciable effects. Their constituents were then identified and also investigated for AChE inhibitory activity. Results revealed a number of constituents were found but their effect on anticho-linesterase activity was not impressive as their originated oils either in single or combination. When turmeric, galangal and fingerroot oils were tested in neuroblastoma SK-N-SH cells, they showed the appreciable potentials in inhibiting cellular AChE of these cells as well.