Publication: Possible involvement of glucocorticoids in mycotoxin-induced neuroinflammation
Issued Date
2015
Resource Type
Language
eng
ISSN
1906-2257
Rights
Mahidol University
Rights Holder(s)
Faculty of Veterinary Science Mahidol University
Bibliographic Citation
Journal of Applied Animal Science. Vol.8, No.1 (Jan-Apr 2015), 17-28
Suggested Citation
Boonrat Chantong, Punnee Nusuetrong Possible involvement of glucocorticoids in mycotoxin-induced neuroinflammation. Journal of Applied Animal Science. Vol.8, No.1 (Jan-Apr 2015), 17-28. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/1706
Research Projects
Organizational Units
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Journal Issue
Thesis
Title
Possible involvement of glucocorticoids in mycotoxin-induced neuroinflammation
Alternative Title(s)
การมีส่วนร่วมของสารกลุ่มกลูโคคอร์ติคอยด์ต่อกระบวนการอักเสบของระบบประสาทที่เกิดจากการชักนำของสารพิษจากเชื้อรา
Author(s)
Abstract
The mycotoxins are commonly encountered in human cereal foods and animal feed throughout the world as a result of infestation of grains in the field and in storage by the fungi including genus Aspergillus, Penicillum and Fusarium. Modulation of the inflammatory responses in the central nervous system (CNS) appears particularly critical role of some relevance mycotoxins such as T-2 toxin, fumonisin B1 and ochratoxin A. Specifically, mentioned mycotoxins disturbed mitogen-activated protein kinases (MAPKs) as well as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) which mediate robust induction of proinflammatory gene expression in both in vitro and in vivo. In CNS, glucocorticoids are powerful endogenous and therapeutic modulators of inflammation though both MAPKs and NF-κB signaling. In addition, toxicity of mycotoxins also was altered with glucocorticoid. Taken together, glucocorticoids may possibly involve in the action of mycotoxins on neuroinflammatory responses. Therefore, factors disturbing glucocorticoid regulation in CNS such as stress, infection, and xenobiotics may enhance response to mycotoxin toxicity. It is anticipated that these investigations will be applicable to identify the therapeutic intervention or prevention.