Publication: Functionalized (poly(e-caprolactone))(2)-poly(ethylene glycol) nanoparticles with grafting nicotinic acid as drug carriers
Submitted Date
2011-09-16
Accepted Date
2011-11-23
Issued Date
2012
Resource Type
Language
eng
ISSN
0378-5173
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Mahidol University
Rights Holder(s)
Elsevier (available from ScienceDirect)
Bibliographic Citation
International Journal of Pharmaceutics. Vol.423, No.2 (2012), 562-70.
Suggested Citation
Jiraphong Suksiriworapong, Kittisak Sripha, Kreuter, Jorg, Varaporn Buraphacheep Junyaprasert, จิรพงศ์ สุขสิริวรพงศ์, กิตติศักดิ์ ศรีภา, วราภรณ์ บูรพาชีพ จรรยาประเสริฐ Functionalized (poly(e-caprolactone))(2)-poly(ethylene glycol) nanoparticles with grafting nicotinic acid as drug carriers. International Journal of Pharmaceutics. Vol.423, No.2 (2012), 562-70.. doi:10.1016/j.ijpharm.2011.00.033 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/61406
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Title
Functionalized (poly(e-caprolactone))(2)-poly(ethylene glycol) nanoparticles with grafting nicotinic acid as drug carriers
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Abstract
Nicotinic acid was grafted on (poly(e-caprolactone))2-poly(ethylene glycol) copolymers that were used for the preparation of nanoparticles with the objectives to monitor particle size and to optimize the drug loading capacity as well as the release profile of the particles. Increasing amounts of grafting nicotinic
acid increased the particle size as a result of an enhanced hydrophobicity of the copolymer. Ibuprofen and indomethacin with two different molecular characteristics were selected as model drugs to be bound to the nanoparticles. The presence of grafting nicotinic acid enhanced the loading capacity for both drugs compared to the nanoparticles without nicotinic acid. However, no correlation between amount of grafting nicotinic acid and loading capacity was observed. The release characteristic of both drugs was fitted to the Higuchi model indicating Fickian diffusion. The release characteristic of indomethacin mainly depended on the crystalline property of the copolymer whereas that of ibuprofen was additionally influenced by the hydrogen bonding between drug and grafted copolymer.
Sponsorship
Financial supported by The Thailand Research Fund (TRF)through the Royal Golden Jubilee Ph.D. Program (Grant No. PHD/0189/2547) and the Thai Research Fund and Commission
of Higher Education, Thailand for the research funding(RMU5180019)