Publication: Three phase bone scintigraphy in evaluating revascularization and bone formation of natural biomaterial bone graft by using Tc99m MDP in rabbits
Issued Date
2015
Resource Type
Language
eng
ISSN
1906-2257
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Mahidol University
Rights Holder(s)
Faculty of Veterinary Science Mahidol University
Bibliographic Citation
Journal of Applied Animal Science. Vol.8, No.2 (2015), 21-32
Suggested Citation
Somkiat Huaijantug, Paranee Yatmark, Somsak Wattananit, Phingphol Charoonrut, Thonnapong Thongpraparn, Rujaporn Chanachai Three phase bone scintigraphy in evaluating revascularization and bone formation of natural biomaterial bone graft by using Tc99m MDP in rabbits. Journal of Applied Animal Science. Vol.8, No.2 (2015), 21-32. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13347
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Title
Three phase bone scintigraphy in evaluating revascularization and bone formation of natural biomaterial bone graft by using Tc99m MDP in rabbits
Alternative Title(s)
การตรวจสแกนกระดูก 3 เพื่อประเมินการเกิดหลอดเลือดและการสร้างกระดูกใหม่ของการปลูกถ่ายกระดูกด้วยวัสดุชีวภาพโดยการใช้สารเภสัชรังสีเทคนิเชียม99m MDP ในกระต่าย
Abstract
Three phase bone scintigraphy (TPBS) examined the viability of bone graft, revascularization, and
bone formation using single photon emission computed tomography (SPECT) and the intravenous injection
of 99M Technetium methylenediphosphonate (99MTc-MDP). Seven New Zealand White rabbits, aged 8 months
had osteotomy of ulna performed, the left ulna substituted for natural biomaterial bone graft, containing
gelatin sponge and hyaluronic acid, and the right ulna was replaced by vascularized autogenous bone graft. A
post-operative scanning of bone using TPBS was done at 7 days and weekly, at week 1, 2, 4, 6, 8, 12 to evaluate
revascularization and bone formation of natural biomaterial bone graft comparing with autogenous bone
graft. The results demonstrated that the perfusion index and RCP of natural biomaterial bone graft and the
autogenous bone graft in phases 1, 2, and 3 had no statistically significant difference when compared in between
each week. The study also showed that, the ratio of the mean counts/pixel of the natural biomaterial bone graft
in phase 3 had slightly lower than autogenous bone graft. This study provided model through which TPBS
could evaluate revascularization and bone formation in this model. Natural biomaterial bone graft may be the
same and as good a revascularization as autogenous bone graft although the bone formation of autogenous
bone graft still has more efficiency than natural biomaterial bone.