Publication: Chemical stability and mechanism of degradation of omeprazole in solution
Issued Date
1998
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
1.97 MB
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Mahidol University
Rights Holder(s)
Chulalongkorn University
Bibliographic Citation
Thai Journal of Pharmaceutical Sciences. Vol. 22, No. 2 (1998), 81-88.
Suggested Citation
Narong Sarisuta, Tudsong Tourtip, Siripote Chuarcharoern, ณรงค์ สาริสุต, ทัดทรง ทั่วทิพย์, ศิริพจน์ เชื้อเจริญ Chemical stability and mechanism of degradation of omeprazole in solution. Thai Journal of Pharmaceutical Sciences. Vol. 22, No. 2 (1998), 81-88.. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/62199
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Title
Chemical stability and mechanism of degradation of omeprazole in solution
Alternative Title(s)
ความคงตัวทางเคมีและกลไกการเสื่อมสลายของโอมิปราโซลในสารละลาย
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Abstract
The chemical stability and kinetics of omeprazole in buffer solutions at various pH values, 5.0, 8.0, and 10.0 were studied at three different stress conditions, 25, 40, and 50 C. It was found that the degradtion reaction followed the pseudo first-order kinetics and was quite rapid at low pH values with a half-life of 43 min at pH 5.0 and 25 C. In alkaline pH of 10.0 the drug was however remarkbly stable with a half-life of 2.8 months at 25 C. The energy of activation was pH-dependent and varied from 9.9-19.6 kcal/mol. The pH-log rate profiles in association with other thermodynamic activation parameters suggested that the main pathway of degradation reaction would be the hydrolysis with depending on hydronium ion concentration involving bimolecular reaction.