Publication: In vitro uterine relaxant activity of Fire Ha Kong Recipe in rats
Issued Date
2014
Resource Type
Language
eng
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application/pdf
No. of Pages/File Size
273.32 KB
ISSN
2286-6493
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Mahidol University
Rights Holder(s)
Asian Association of Schools of Pharmacy
Bibliographic Citation
Journal of Asian Association of Schools of Pharmacy. Vol.3, (2014), 299‐305.
Suggested Citation
Penchom Peungvicha, Yuvadee Wongkrajang, Boontium Kongsaktrakoon, Kanjana Jittiporn, Somsak Nualkaew, เพ็ญโฉม พึ่งวิชา, ยุวดี วงษ์กระจ่าง, บุญเทียม คงศักดิ์ตระกูล, สมศักดิ์ นวลแก้ว In vitro uterine relaxant activity of Fire Ha Kong Recipe in rats. Journal of Asian Association of Schools of Pharmacy. Vol.3, (2014), 299‐305.. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/62716
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Title
In vitro uterine relaxant activity of Fire Ha Kong Recipe in rats
Corresponding Author(s)
Abstract
Fire Ha Kong recipe in a concentration range of 10-40 µl/ml was used to test in an in vitro uterine contraction inhibition. Contraction frequencies and amplitudes of the normal uterine of estrogen-primed non-pregnant rats were monitored. A decline in the frequencies of uterine contractions of 43.8 - 93.6% was detected. Addition of Fire Ha Kong at the final concentrations of 20-40 ?l/ml inhibited the amplitudes of uterus contraction by 57.1% and 85.7%, respectively. The reductions in area under the curve (AUC) of contractions were 57.1% and 85.7% for the added concentrations. Fire Ha Kong recipe revealed inhibitory effects on the uterine response to oxytocin (10-11 M) 31.9% and 29.3% only in frequency but not in amplitude and AUC in comparison to oxytocin alone. These results indicate that the tocolytic potential of Fire Ha Kong recipe may involve oxytocin receptor-dependent pathway or reduce the intracellular availability of calcium ions.