Publication: Cassia tora Linn. seed extract prolongs sleeping time and reduces locomotor activity in mice
Issued Date
1996
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
398 KB
ISSN
0858-9399
Rights
Mahidol University
Rights Holder(s)
Faculty of Pharmacy Mahidol University.
Bibliographic Citation
Thai Journal of Phytopharmacy. Vol. 3, No.2, (1996), 1-6.
Suggested Citation
Peungvicha P, Suvitayavat W, Kongsaktrakoon B, Temsiririrkkul R, Wongkrajang Y, Penchom Peungvicha, Wisuda Suvitayavat, เพ็ญโฉม พึ่งวิชา, วิสุดา สุวิทยาวัฒน์, บุญเทียม คงศักดิ์ตระกูล, รุ่งระวี เต็มศิริฤกษ์กุล, ยุวดี วงษ์กระจ่าง Cassia tora Linn. seed extract prolongs sleeping time and reduces locomotor activity in mice. Thai Journal of Phytopharmacy. Vol. 3, No.2, (1996), 1-6.. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/62120
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Title
Cassia tora Linn. seed extract prolongs sleeping time and reduces locomotor activity in mice
Abstract
Cassla toraLinn. seeds have been used intraditional medicine as atranquillizers butthere is little information on their effect on the central nervous system. The effects of a decoction of Cassla tora Linn. seeds on sleep and locomotor activity was investigated. Feeding of seed extract at doses of o.5 and 1 g/kg prolonged the barbiturate-induced sleeping time in both sexes of mice, no stee;rinducing activity alone if that's from this study. The extract at doses of o.25 and o.5 gzkg decreased locomotor activity at 30 minutes after feeding (e . o.os) but did not decrease locomotor activity in amphetamine-treated mice. These results suggested that the water extract of Cassia tora seeds potentiated the efFect of barbiturate and suppressed the function of the central nervous system. Administration of 5 g/kgorally or 2 g/kgintraperitoneally caused no acute toxicity in rarts or mice. Phytochemical screening of the extract detected only anthraquinone. These results suppprt the claimed tranquillizer effect of Cassla seed extract.