Publication: Alteration of extracellular matrix components in the anterior pituitary gland of neonatal rats induced by a maternal bisphenol a diet during pregnancy
2
Issued Date
2021-12-01
Resource Type
ISSN
14220067
16616596
16616596
Other identifier(s)
2-s2.0-85119588468
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Molecular Sciences. Vol.22, No.23 (2021)
Suggested Citation
Bumpenporn Sanannam, Sasikarn Looprasertkul, Songphon Kanlayaprasit, Nakarin Kitkumthorn, Tewarit Sarachana, Depicha Jindatip Alteration of extracellular matrix components in the anterior pituitary gland of neonatal rats induced by a maternal bisphenol a diet during pregnancy. International Journal of Molecular Sciences. Vol.22, No.23 (2021). doi:10.3390/ijms222312667 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/75907
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Alteration of extracellular matrix components in the anterior pituitary gland of neonatal rats induced by a maternal bisphenol a diet during pregnancy
Abstract
The extracellular matrix (ECM) plays crucial roles in the anterior pituitary gland via the mechanism of cell–ECM interaction. Since bisphenol A (BPA), a well-known endocrine disruptor, can cross through the placenta from mother to fetus and bind with estrogen receptors, cell popula-tions in the neonatal anterior pituitary gland could be the target cells affected by this chemical. The present study treated maternal rats with 5000 µg/kg body weight of BPA daily throughout the preg-nancy period and then investigated the changes in ECM-producing cells, i.e., pericytes and follicu-lostellate (FS) cells, including their ECM production in the neonatal anterior pituitary at Day 1. We found that pericytes and their collagen synthesis reduced, consistent with the increase in the number of FS cells that expressed several ECM regulators—matrix metalloproteinase (MMP) 9 and the tissue inhibitors of metalloproteinase (TIMP) family. The relative MMP9/TIMP1 ratio was extremely high, indicating that the control of ECM homeostasis was unbalanced. Moreover, transmission electron microscopy showed the unorganized cell cluster in the BPA-treated group. This study revealed that although the mother received BPA at the “no observed adverse effect” level, alterations in ECM-producing cells as well as collagen and the related ECM balancing genes occurred in the neonatal anterior pituitary gland.