การเปรียบเทียบผลของ Bupivacaine Lidocaine and Xylazine สำหรับระงับความเจ็บปวด ระบบหัวใจและหลอดเลือด โดยวิธีการฉีดเข้าช่องไขสันหลังส่วน Lumbosacral ในวัวพันธุ์ผสมพื้นเมือง

Abstract

The objective of the research was to determine the onset, duration, analgesic, ataxic after doing lumbosacral epidural injection with bupivacaine, lidocaine or xylazine as an analgestic drug. Twelve adult crossbreed native cattle were assigned in three groups as a randomized, Completely Randomized Design. 0.5% bupivacaine hydrochloride (0.025 mg/kg) in group 1, 2% lidocaine hydrochloride without epinephrine (0.22 mg/kg) in group 2, 2% xylazine hydrochloride (0.05 mg/kg) in group 3, the cattle got the each drug by lumbosacral epidural injection at L6-S1 area with 0.5 ml/second on speed. The results of the onset time (bupivacaine = 5.5 ± 0.43 minutes, lidocaine = 5.75 ± 0.89 minutes, xylazine = 7.75 ± 1.43 minutes) were not significantly different in all analgesic drugs (p>0.05). The duration of the analgesic drugs also were not significantly different (p>0.05) : bupivacaine = 93.75 ± 31.09 minutes, lidocaine = 72.50 ± 9.76 minutes, xylazine = 169.0 ± 35.81 minutes. The parameter of heart rate (HR), respiratory rate (RR) and rumen contraction rate (RCR) in bupivacaine lidocaine or xylazine were significantly different in all analgesic drugs inspectively (p<0.05): HR (57.10 ± 3.98ab 65.25± 5.26a or 48.63 ± 2.80b bpm) RR (29.19 ± 2.89a 24.0 ± 1.63ab or 16.35 ± 2.02b bpm) RCR (2.63 ± 0.12a 1.60 ± 0.24b or 1.78 ± 0.33ab completely cycle per two minutes). The next surgery will choose the best data of analgesic drug for lumbosacral epidural injection in crossbreed native cattle.