Publication: Novel drug compounds against neospora caninum and toxoplasma gondill in vitro.
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Issued Date
2007
Resource Type
Language
eng
Rights
Mahidol University
Rights Holder(s)
Faculty of Tropical Medicine
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol. 38 (Suppl. 1), (2007),15-18
Suggested Citation
Jitbanjong Wiengcharoen., Ryan O'Hanley., Tanya Armstrong., Wayne Best., Yaowalark Sukthana., RC Andrew Thompson. Novel drug compounds against neospora caninum and toxoplasma gondill in vitro.. Southeast Asian Journal of Tropical Medicine and Public Health. Vol. 38 (Suppl. 1), (2007),15-18. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/9904
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Thesis
Title
Novel drug compounds against neospora caninum and toxoplasma gondill in vitro.
Abstract
Neospora caninum has recently been identified as an important cause of
abortion in cattle worldwide. This parasite is closely related to Toxoplasma
gondii. To identify the drug compounds for potential use against both parasites
in vitro, nine novel drug compounds were incubated with either parasite on
microtiter plate. The number of extracellular tachyzoites and the quantities of
Vero cells left in the wells after incubating with those nine drugs were
compared to the conventional drug control, a combination of sulfadiazine 25
μg/ml and pyrimethamine 0.1 μg/ml. The most effective drugs against both N.
caninum and T. gondii in this study were trifluralin analogues.