Publication: Uterotropic activity of the solvent extracts of white Kwao Krua from Two Sources
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Issued Date
2004
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eng
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application/pdf
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2724069 bytes
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Mahidol University
Bibliographic Citation
Mahidol University Journal of Pharmaceutical Sciences. Vol. 31, No.3-4 (2004), 54-60.
Suggested Citation
Nongluck Sookvanichsilp, Noppamas Soonthornchareonnon, Naun-anong Tad-ura Uterotropic activity of the solvent extracts of white Kwao Krua from Two Sources. Mahidol University Journal of Pharmaceutical Sciences. Vol. 31, No.3-4 (2004), 54-60.. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/62182
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Title
Uterotropic activity of the solvent extracts of white Kwao Krua from Two Sources
Abstract
The root of white "Kwao Krua" has been used by Thai people as a rejuvenating folk medicine for a
long period of time. The uterotropic activity and the TLC of the ethanolic and the dichloromethane extracts of
white "Kwao Krua" roots from two sources, Pueraria cando/lei Benth. var. mirifica (Airy Shaw and Suvat)
Niyomdham and Pueraria cando/lei Benth. var. cando/lei were determined and compared. In uterotropic assay,
the ethanolic and the dichloromethane extracts at doses ranging uom 1 to 10 and 0.1 to 1 mg/kg'day, respectively,
were given orally to immature female rats for 3 consecutive days. In TLC determination, the extracts were
submitted to silica gel GF254 plates using two developing solvent systems, chloroform: methanol (8:2) and ethyl
acetate: chloroform (6:4). The results revealed a higher uterotropic potency of the dichloromethane extract over
the ethanolic extract, and the extracts of Pueraria cando/lei var. mirifica exhibited higher uterotropic activity than
those ofPueraria cando/lei var. cando/lei. TLC chromatograms of the extracts of white "Kwao Krua" from two
sources were similar. The bands of daidzein and genistein were more clearly seen on the dichloromethane
chromatogram than on the et hanolic chromatogram of white "Kwao Krua" roots from both sources. @AII rights reserved.