Journal Issue: JAAS Vol. 9 No. 3
Issued Date
2559
Resource Type
Language
eng
tha
tha
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application/pdf
Access Rights
open access
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ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
คณะสัตวแพทยศาสตร์ มหาวิทยาลัยมหิดล
Journal Volume
JAAS Volume 9
(2559)
Articles
The function of Vascular Endothelial Growth Factor in cancer metastasis
(2016) Kanjana Assawasuparerk; Mahidol University. Faculty of Veterinary Science. Department of Pre-clinic and Applied Animal Science
Cancer metastasis is one of the leading causes of death in humans and animals diagnosed with cancer.
It is a complex process that involves the spread of cancer cells from the primary cancer to another parts of the
body through lymphatic and blood vessels. Cancer angiogenesis and lymphangiogenesis have been considered
as essential processes in the cancer metastasis because the new formation blood and lymphatic vessels occur,
thereby creating new route for cancer cells to metastasize. Vascular endothelial growth factors (VEGF) is a
protein previously known for the role in promoting vasculogenesis and angiogenesis. Overexpression of VEGF
is known to be implicated in a wide variety of disease processes, especially cancer metastatic process. At present,
there are 7 members of the VEGF family, including VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F,
and PlGF. Among all VEGF members, VEGF-A, VEGF-C and VEGF-D have been reported to be capable to
promote cancer angiogenesis and lymphangiogenesis. Moreover, the molecular mechanism of VEGFs and
their interaction with the VEGF receptors (VEGFRs) which involve in the processes of cancer metastasis
has been extensively described in details. The previous research has shown that VEGF-A plays a major role in
angiogenesis through the interaction with VEGFR1 and VEGFR2 receptors as well as with neuropilins
presented on the endothelial cells. Following the stimulation of several signal transduction pathways, these
interaction result in the endothelial cell proliferation and migration, by which subsequently leads to finally
the neovascularization. Apart from the role of VEGF-A, in addition to the role of VEGF-A associated with
angiogenesis, VEGF-C and VEGF-D have also been recently reported for their major roles in lymphagiogenesis
through the interaction with VEGFR3 which is mostly present in lymphatic endothelial cells. Moreover,
VEGF-C and VEGF-D are able to promote angiogenesis. Therefore, the inhibition of VEGF-A, VEGF-C, VEGF-D,
and VEGFRs might be used in cancer treatment for the reduction in cancer metastasis.
Effect of dietary fish oil supplement on nutrients digestibility and egg yolk omega-3 fatty acids contents in Japanese Quails
(2016) Kunaporn Homyog; Surasak Jittakhot; Samatchaya Pengdit; Mahidol University. Faculty of Veterinary Science
This study were investigated the effects of dietary fish oil supplement on digestibility of nutrients, fatty acid
composition of egg yolk and quality of eggs in Japanese quails. Three hundred and twenty, ten weeks old female
Japanese quails were randomly divided into 2 treatments, replicated 8 cages with 20 birds per cage. Dietary
treatments; control diet and fish oil supplement diet (added 6% fish oil) were fed for 30 days. Samples of diets, feces
and egg were daily collected from last 5 days. For proximate analysis of fish oil supplement DM, EE and ash of
feed intake were lower than control diet (P<0.01). Moreover, the dietary fish oil supplement on macronutrients
digestibility revealed DM, ME (P<0.05) and ash were significantly decrease (P<0.01) and also found negative effect
on nitrogen metabolism (P<0.05). Fish oil supplement had significantly negative effect on egg production, egg
weight and yolk width (P<0.05). However, detected the increasing of saturated fatty acids, unsaturated fatty
acids, omega 3 and omega 9 fatty acids contents of quails fed fish oil supplement diet (P<0.01). On the other hand,
fish oil supplement diets were highly significant decrease in omega 6 fatty acids and omega 6 to omega 3 fatty acid
ratio (P<0.01). In summary, dietary fish oil supplemented can caused positive effect on content of saturated fatty
acids, unsaturated fatty acids, omega 3 and omega 9 fatty acids, but had adverse effect either macro-nutrients
intake or their digestibility. Additionally dietary fish oil supplemented lead to lower omega 6 to omega 3 ratios
that cloud be beneficial effect on human health.
Comparison of the longissimus dorsi muscle tone in Thoroughbred racehorses before and after training
(2016) Pichet Jewmongkonchai; Arunothai Muangma; Pattama Ritruechai; Mahidol University. Faculty of Veterinary Science. Department of Clinical Science and Public Health
The longissimus dorsi is the largest back muscle of the horse and has the potential to contribute movement
to the horse's back. Damage to the longissimus dorsi is very common to cause back injuries, which is also a
major cause of poor performance and gait abnormalities in horses. The muscle indenter is a tool that allows
measuring the stiffness of the back muscles. We hypothesized that the longissimus dorsi muscle tone after
training would be stiffer than at rest. One sound mare and three gelding Thoroughbred racehorses were used
in this study. The muscle tone was measured using a muscle indenter along both sides of the T14, T16, T18 and
L2 longissimus dorsi muscle. Blood sample were collected to measure the blood lactate concentration before
and after training. Heart rate was measured at rest and at 0, 5, 10, 15 and 20 minutes after training. We found
a significant increase in muscle tone after training at T14, T16 and T18. The blood lactate concentration of
studied horses significantly increased after training, although the values were still within the normal range.
The recovery heart rates for all horses are tended to decrease (< 70 bpm) after 5 minutes of stopping exercise.
We confirmed that the longissimus dorsi is a key muscle in horse movement that can be sensitive to relatively
small training sessions; that is why this muscle is prone to get injured. Generally, the muscle intender was a
successful tool of objectively measuring this muscle tone.
Title
JAAS Vol. 9 No. 3
Author's Affiliation
มหาวิทยาลัยมหิดล. คณะสัตวแพทยศาสตร์