Detection of deacetylmetipranolol arising from storage of standard solution of metipranolol
Issued Date
2015
Resource Type
Language
eng
Rights
Mahidol University
Rights Holder(s)
National Doping Control Centre Mahidol University
Suggested Citation
Inthong T, Matayatsuk Phechkrajang C, Wilairat P, Chaikum N (2015). Detection of deacetylmetipranolol arising from storage of standard solution of metipranolol. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/44137
Title
Detection of deacetylmetipranolol arising from storage of standard solution of metipranolol
Other Contributor(s)
Abstract
Metipranolol is a beta-blocker in the WADA list of substances prohibited in particular sports. It is converted to deacetylmetipranolol by the first pass metabolism and the parent compound is not excreted. A standard methanolic solution of metipranolol can be converted to deacetylmetipranolol during prolonged storage at -20°C. Spiking blank urine with this aged standard can lead to misinterpretation of the form of metipranolol in a suspected urine sample since the normal GC-MS screening procedure for derivatized beta-blockers cannot separate this metabolite from the parent compound. A specific Ge-temperature program is required. However a LC-MS/MS method can separate metipranolol and its metabolite.
Description
Recent advances in doping analysis (22) : Proceedings of the Manfred-Donike-Workshop ; 32nd Cologne Workshop on Dope Analysis ; 30th March to 4th April 2014, page 79-83
