117 results
Search Results
Now showing 1 - 10 of 117
Publication Metadata only Epidemiological characteristics, ventilator management, and clinical outcome in patients receiving invasive ventilation in intensive care units from 10 Asian middle-income countries (PRoVENT-iMiC): An international, multicenter, prospective study(2021-03-01) Luigi Pisani; Anna Geke Algera; Ary Serpa Neto; Areef Ahsan; Abigail Beane; Kaweesak Chittawatanarat; Abul Faiz; Rashan Haniffa; Seyed Mohammad Reza Hashemian; Madiha Hashmi; Hisham Ahmed Imad; Kanishka Indraratna; Shivakumar Iyer; Gyan Kayastha; Bhuvana Krishna; Tai Li Ling; Hassan Moosa; Behzad Nadjm; Rajyabardhan Pattnaik; Sriram Sampath; Louise Thwaites; Ni Ni Tun; Norazim Mohd Yunos; Salvatore Grasso; Frederique Paulus; Marcelo Gama de Abreu; Paolo Pelosi; Nick Day; Nicholas J. White; Arjen M. Dondorp; Marcus J. Schultz; Universitätsklinikum Carl Gustav Carus Dresden; Faculty of Tropical Medicine, Mahidol University; Oxford University Clinical Research Unit; IRCCS San Martino Polyclinic Hospital; Bharati Vidyapeeth Medical College, Pune; Indira Gandhi Memorial Hospital Male; Sri Jayewardenepura General Hospital; Ispat General Hospital; The Aga Khan University; Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders; Kuala Lumpur Hospital; Università degli Studi di Genova; Università degli studi di Bari Aldo Moro; Shahid Beheshti University of Medical Sciences; Hospital Israelita Albert Einstein; University of Malaya Medical Centre; Nuffield Department of Medicine; Amsterdam UMC - University of Amsterdam; Chiang Mai University; 19Medical Action Myanmar; St. John’s Medical College; Dev Care Foundation; Patan Academy of Health SciencesEpidemiology, ventilator management, and outcome in patients receiving invasive ventilation in intensive care units (ICUs) in middle-income countries are largely unknown. PRactice of VENTilation in Middle-income Countries is an international... multicenter 4-week observational study of invasively ventilated adult patients in 54 ICUs from 10 Asian countries conducted in 2017/18. Study outcomes included major ventilator settings (including tidal volume [VT] and positive end-expiratory pressure [PEEPPublication Metadata only A prospective study of the importance of enteric fever as a cause of non-malarial febrile illness in patients admitted to Chittagong Medical College Hospital, Bangladesh(2016-10-13) Rapeephan R. Maude; Aniruddha Ghose; Rasheda Samad; Hanna K. de Jong; Masako Fukushima; Lalith Wijedoru; Mahtab Uddin Hassan; Md Amir Hossain; Md Rezaul Karim; Abdullah Abu Sayeed; Stannie van den Ende; Sujat Pal; A. S.M. Zahed; Wahid Rahman; Rifat Karnain; Rezina Islam; Dung Thi Ngoc Tran; Tuyen Thanh Ha; Anh Hong Pham; James I. Campbell; H. Rogier van Doorn; Richard J. Maude; Tom van der Poll; W. Joost Wiersinga; Nicholas P.J. Day; Stephen Baker; Arjen M. Dondorp; Christopher M. Parry; Md Abul Faiz; Mahidol University; Chittagong Medical College Hospital; Academic Medical Centre, University of Amsterdam; Liverpool School of Tropical Medicine; UCL; Nuffield Department of Clinical Medicine; London School of Hygiene & Tropical Medicine; Nagasaki University; Dev Care Foundationin 34 (11.3 %) of patients. Of note Rickettsia typhi and Orientia tsutsugamushi were detected by PCR in two and one patient respectively. Twenty-nine (9 %) patients died during their hospital admission (15/160 (9.4 %) of children and 14/144 (9...© 2016 The Author(s). Background: Fever is a common cause of hospital admission in Bangladesh but causative agents, other than malaria, are not routinely investigated. Enteric fever is thought to be common. Methods: Adults and children admittedPublication Metadata only High mobility group box 1 and interleukin 6 at intensive care unit admission as biomarkers in critically Ill COVID-19 Patients(2021-07-01) Chaisith Sivakorn; Jutamas Dechsanga; Lawan Jamjumrus; Kobporn Boonnak; Marcus J. Schultz; Arjen M. Dondorp; Weerapong Phumratanaprapin; Ranistha Ratanarat; Thummaporn Naorungroj; Patchrapa Wattanawinitchai; Tanaya Siripoon; Chatnapa Duangdee; Tachpon Techarang; Siriraj Hospital; Faculty of Tropical Medicine, Mahidol University; Chonburi Regional Hospital; Walailak University; Nuffield Department of Medicine; Universiteit van Amsterdam; Buddhasothorn Hospital(HMGB1) and interleukin-6 (IL-6), in patients with severe COVID-19 at the time of admission in the intensive care unit (ICU). Of 60 ICU patients with COVID-19 enrolled and analyzed in this prospective cohort study, 48 patients (80%) were alive at ICU... discharge. HMGB1 and IL-6 plasma levels at ICU admission were elevated compared with a healthy control, both in ICU nonsurvivors and ICU survivors. HMGB1 and IL-6 plasma levels were higher in patients with a higher Sequential Organ Failure Assessment (SOFAPublication Metadata only Effectiveness of a sepsis programme in a resource-limited setting: A retrospective analysis of data of a prospective observational study (Ubon-sepsis)(2021-02-18) Suchart Booraphun; Viriya Hantrakun; Suwatthiya Siriboon; Chaiyaporn Boonsri; Pulyamon Poomthong; Bung Orn Singkaew; Oratai Wasombat; Parinya Chamnan; Ratapum Champunot; Kristina Rudd; Nicholas P.J. Day; Arjen M. Dondorp; Prapit Teparrukkul; Timothy Eoin West; DIrek Limmathurotsakul; Faculty of Tropical Medicine, Mahidol University; University of Washington; Nuffield Department of Medicine; University of Pittsburgh School of Medicine; Sunpasitthiprasong Hospital; Buddhachinaraj Phitsanulok Hospital) from March 2013 to January 2017. Setting General medical wards and medical intensive care units (ICUs) of a study hospital. Participants Patients with community-acquired sepsis observed under the Ubon-sepsis cohort. Sepsis was defined as modified... Sequential Organ Failure Assessment (SOFA) Score ≥2. Main exposure The SFT programme was a protocol to identify and initiate sepsis care on hospital admission, implemented at the study hospital in 2015. Patients in the SFT programme were admitted directlyPublication Metadata only RELAx - REstricted versus Liberal positive end-expiratory pressure in patients without ARDS: Protocol for a randomized controlled trial(2018-05-09) Anna Geke Algera; Luigi Pisani; Dennis C.J. Bergmans; Sylvia den Boer; Corianne A.J. de Borgie; Frank H. Bosch; Karina Bruin; Thomas G. Cherpanath; Rogier M. Determann; Arjen M. Dondorp; Dave A. Dongelmans; Henrik Endeman; Jasper J. Haringman; Janneke Horn; Nicole P. Juffermans; David M. van Meenen; Nardo J. van der Meer; Maruschka P. Merkus; Hazra S. Moeniralam; Ilse Purmer; Pieter Roel Tuinman; Mathilde Slabbekoorn; Peter E. Spronk; Alexander P.J. Vlaar; Marcelo Gama de Abreu; Paolo Pelosi; Ary Serpa Neto; Marcus J. Schultz; Frederique Paulus; Ospedale Policlinico San Martino; Gelre Ziekenhuizen; Amphia Hospital; HagaZiekenhuis; St. Antonius Ziekenhuis; Dresden University Faculty of Medicine and University Hospital Carl Gustav Carus; Our Lady Hospital - Amsterdam; Hospital Israelita Albert Einstein; Mahidol University; University Hospital Maastricht; Isala Clinics; Amsterdam UMC - Vrije Universiteit Amsterdam; Amsterdam UMC - University of Amsterdam; Spaarne Gasthuis; Rijnstate; Haaglanden Medical Center© 2018 The Author(s). Background: Evidence for benefit of high positive end-expiratory pressure (PEEP) is largely lacking for invasively ventilated, critically ill patients with uninjured lungs. We hypothesize that ventilation with low PEEP... is noninferior to ventilation with high PEEP with regard to the number of ventilator-free days and being alive at day 28 in this population. Methods/Design: The "REstricted versus Liberal positive end-expiratory pressure in patients without ARDS" trial (RELAxPublication Metadata only Point-of-care lung ultrasound for the detection of pulmonary manifestations of malaria and sepsis: An observational study(2018-12-01) Stije J. Leopold; Aniruddha Ghose; Katherine A. Plewes; Subash Mazumder; Luigi Pisani; Hugh W.F. Kingston; Sujat Paul; Anupam Barua; M. Abdus Sattar; Michaëla A.M. Huson; Andrew P. Walden; Patricia C. Henwood; Elisabeth D. Riviello; Marcus J. Schultz; Nicholas P.J. Day; Asok Kumar Dutta; Nicholas J. White; Arjen M. Dondorp; Brigham and Women's Hospital; Mahidol University; Chittagong Medical College Hospital; Nuffield Department of Clinical Medicine; Royal Berkshire Hospital; Harvard Medical School; Amsterdam UMC - University of Amsterdam-constrained hospital setting. LUS was highly feasible and allowed to accurately identify patients at risk of death in a resource limited setting.... are credited. Introduction Patients with severe malaria or sepsis are at risk of developing life-threatening acute respiratory distress syndrome (ARDS). The objective of this study was to evaluate point-of-care lung ultrasound as a novel tool to determinePublication Metadata only Respiratory support in COVID-19 patients, with a focus on resource-limited settings(2020-06-01) Arjen M. Dondorp; Muhammad Hayat; Diptesh Aryal; Abi Beane; Marcus J. Schultz; Mahidol University; Nuffield Department of Medicine; Amsterdam UMC - University of Amsterdam; Nepal Mediciti Hospital; Northwest General Hospital and Research Centrebilateral pneumonia is the main feature of severe COVID-19, and adequate ventilatory support is crucial for patient survival. Although our knowledge of the disease is still rapidly increasing, this review summarizes current guidance on the best provision... of ventilatory support, with a focus on resource-limited settings. Key messages include that supplemental oxygen is a first essential step for the treatment of severe COVID-19 patients with hypoxemia and should be a primary focus in resource-limited settingsPublication Metadata only Magnetic resonance imaging of cerebral malaria patients reveals distinct pathogenetic processes in different parts of the brain(2017-05-01) Sanjib Mohanty; Laura A. Benjamin; Megharay Majhi; Premanand Panda; Sam Kampondeni; Praveen K. Sahu; Akshaya Mohanty; Kishore C. Mahanta; Rajyabardhan Pattnaik; Rashmi R. Mohanty; Sonia Joshi; Anita Mohanty; Ian W. Turnbull; Arjen M. Dondorp; Terrie E. Taylor; Samuel C. Wassmer; Ispat General Hospital; University of Liverpool; Queen Elizabeth Central Hospital Malawi; Institute of Life Sciences India; North Manchester General Hospital; Mahidol University; Nuffield Department of Clinical Medicine; Michigan State University; University of Malawi College of Medicine; London School of Hygiene & Tropical Medicinein Rourkela, India, of 11 Indian patients hospitalized with CM and increased brain volume. Among the 11 cases, there were 5 adults and 6 children. All patients had reduced consciousness and various degrees of cortical swelling at baseline. The latter...© 2017 Mohanty et al. The mechanisms underlying the rapidly reversible brain swelling described in patients with cerebral malaria (CM) are unknown. Using a 1.5-Tesla (T) magnetic resonance imaging (MRI) scanner, we undertook an observational studyPublication Metadata only Central venous catheter use in severe malaria: Time to reconsider the World Health Organization guidelines?(2011-11-17) Josh Hanson; Sophia Wk Lam; Sanjib Mohanty; Shamshul Alam; Md Mahtab Hasan; Sue J. Lee; Marcus J. Schultz; Prakaykaew Charunwatthana; Sophie Cohen; Ashraf Kabir; Saroj Mishra; Nicholas Pj Day; Nicholas J. White; Arjen M. Dondorp; Cairns Base Hospital; Mahidol University; Ispat General Hospital; Chittagong Medical College Hospital; Academic Medical Centre, University of Amsterdam; Cox's Bazar Medical College; Nuffield Department of Clinical MedicineBackground: To optimize the fluid status of adult patients with severe malaria, World Health Organization (WHO) guidelines recommend the insertion of a central venous catheter (CVC) and a target central venous pressure (CVP) of 0-5 cmH 2 O. However... there are few data from clinical trials to support this recommendation. Methods. Twenty-eight adult Indian and Bangladeshi patients admitted to the intensive care unit with severe falciparum malaria were enrolled in the study. All patients had a CVC insertedPublication Metadata only Direct in vivo assessment of microcirculatory dysfunction in severe falciparum malaria(2008-01-01) Arjen M. Dondorp; C. Ince; P. Charunwatthana; J. Hanson; A. Van Kuijen; M. A. Faiz; M. R. Rahman; M. Hasan; E. Bin Yunus; A. Ghose; R. Ruangveerayut; D. Limmathurotsakul; K. Mathura; N. J. White; N. P.J. Day; Academic Medical Centre, University of Amsterdam; Mahidol University; Mae Sot General Hospital; Nuffield Department of Clinical Medicine; Dhaka Medical College; Chittagong Medical College HospitalBackground. This study sought to describe and quantify microcirculatory changes in the mucosal surfaces of patients with severe malaria, by direct in vivo observation using orthogonal polarization spectral (OPS) imaging. Methods.... The microcirculation in the rectal mucosa of adult patients with severe malaria was assessed by use of OPS imaging, at admission and then daily. Comparison groups comprised patients with uncomplicated falciparum malaria, patients with bacterial sepsis, and healthy