9 results
Search Results
Now showing 1 - 9 of 9
Publication Metadata only Retinal changes in visceral leishmaniasis by retinal photography(2014-09-30) Richard J. Maude; BUM U.M.W. Ahmed; Abu Hayat Md Waliur Rahman; Ridwanur Rahman; Mohammed I. Majumder; Darryl B. Menezes; Abdullah Abu Sayeed; Laura Hughes; Thomas J. MacGillivray; Shyamanga Borooah; Baljean Dhillon; Arjen M. Dondorp; Mohammad A. Faiz; Mahidol University; Nuffield Department of Clinical Medicine; University of Edinburgh, College of Medicine and Veterinary Medicine; Sir Salimullah Medical College; Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust; Chittagong Medical College Hospital; University of Edinburghretinal photography. The photographs were assessed by masked observers including assessment for vessel tortuosity using a semi-automated system.Results: 30 patients with VL were enrolled, of whom 6 (20%) had abnormalities. These included 5 with focal... retinal whitening, 2 with cotton wool spots, 2 with haemorrhages, as well as increased vessel tortuosity. Visual function was preserved.Conclusions: These changes suggest a previously unrecognized retinal vasculopathy. An inflammatory aetiologyPublication Metadata only Short report: Reversibility of retinal microvascular changes in severe falciparum malaria(2014-01-01) Richard J. Maude; Hugh W.F. Kingston; Sonia Joshi; Sanjib Mohanty; Saroj K. Mishra; Nicholas J. White; Arjen M. Dondorp; Mahidol University; Ispat General Hospitalprominent retinal whitening with corresponding retinal microvascular obstruction, vessel dilatation, increased vascular tortuosity, and blood retinal barrier leakage with decreased visual acuity, all of which resolved on recovery. Additional studyPublication Metadata only Reduced microcirculatory flow in severe falciparum malaria: Pathophysiology and electron-microscopic pathology(2004-01-01) Arjen M. Dondorp; Emsri Pongponratn; Nicholas J. White; Mahidol University; John Radcliffe Hospitalvessels. Besides, parasitized red cells become rigid, compromising their flow through capillaries whose lumen has been reduced by sequestered erythrocytes. Adhesive forces between infected red cells (auto-agglutination), between infected and uninfected redPublication Metadata only Effects of malaria heme products on red blood cell deformability(2007-10-01) Forradee Nuchsongsin; Kesinee Chotivanich; Prakaykaew Charunwatthana; Omodeo Salè Fausta; Donatella Taramelli; Nicholas P. Day; Nicholas J. White; Arjen M. Dondorp; Mahidol University; Universita degli Studi di MilanoIn falciparum malaria, the deformability of the entire erythrocyte population is reduced in proportion to disease severity, and this compromises microcirculatory blood flow through vessels partially obstructed by cytoadherent parasitizedPublication Metadata only The eye in cerebral malaria: what can it teach us?(2009-07-01) Richard J. Maude; Arjen M. Dondorp; Abdullah Abu Sayeed; Nicholas P.J. Day; Nicholas J. White; Nicholas A.V. Beare; Mahidol University; John Radcliffe Hospital; Chittagong Medical College Hospital; Royal Liverpool and Broadgreen University Hospitals NHS Trustthe hypothesis that the sequestration of erythrocytes in small blood vessels and consequent obstruction of microcirculatory flow is an important mechanism causing coma and death in CM. Despite advances in the antimalarial treatment of severe malaria, itsPublication Metadata only Coma in fatal adult human malaria is not caused by cerebral oedema(2011-09-21) Isabelle M. Medana; Nicholas Pj Day; Navakanit Sachanonta; Nguyen Th Mai; Arjen M. Dondorp; Emsri Pongponratn; Tran T. Hien; Nicholas J. White; Gareth Dh Turner; University of Oxford; Nuffield Department of Clinical Medicine; Mahidol University; UCLsequestration and resultant microvascular congestion in cerebral vessels. To determine whether these changes cause breakdown of the blood-brain barrier and resultant perivascular or parenchymal cerebral oedema, histology, immunohistochemistry and image analysisPublication Metadata only Direct in vivo assessment of microcirculatory dysfunction in severe falciparum malaria(2008-01-01) Arjen M. Dondorp; C. Ince; P. Charunwatthana; J. Hanson; A. Van Kuijen; M. A. Faiz; M. R. Rahman; M. Hasan; E. Bin Yunus; A. Ghose; R. Ruangveerayut; D. Limmathurotsakul; K. Mathura; N. J. White; N. P.J. Day; Academic Medical Centre, University of Amsterdam; Mahidol University; Mae Sot General Hospital; Nuffield Department of Clinical Medicine; Dhaka Medical College; Chittagong Medical College Hospitalof disease. Blocked capillaries were found in 29 patients (67%) and were associated with concurrent hyperdynamic blood flow (erythrocyte velocity, >750 mm/s) in adjacent vessels in 27 patients (93%). The proportion of blocked capillaries correlatedPublication Metadata only A quantitative ultrastructural study of renal pathology in fatal Plasmodium falciparum malaria(2007-09-01) Sudarat Nguansangiam; Nicholas P J Day; Tran Tinh Hien; Nguyen Thi Hoang Mai; Urai Chaisri; Mario Riganti; Arjen M. Dondorp; Sue J. Lee; Nguyen Hoan Phu; Gareth D H Turner; Nicholas J. White; David J P Ferguson; Emsri Pongponratn; Mahidol University; Vajira Hospital; Nuffield Department of Clinical Medicine; Cho Quan Hospitalfeatures included PRBC sequestration in glomerular and tubulo-interstitial vessels, acute tubular damage and mild glomerular hypercellularity resulting from the accumulation of host monocytes within glomerular capillaries. No evidence for an immune complexPublication Metadata only The spectrum of retinopathy in adults with Plasmodium falciparum malaria(2009-07-01) Richard J. Maude; Nicholas A V Beare; Abdullah Abu Sayeed; Christina C. Chang; Prakaykaew Charunwatthana; M. Abul Faiz; Amir Hossain; Emran Bin Yunus; M. Gofranul Hoque; Mahtab Uddin Hasan; Nicholas J. White; Nicholas P J Day; Arjen M. Dondorp; Mahidol University; John Radcliffe Hospital; Royal Liverpool and Broadgreen University Hospitals NHS Trust; Chittagong Medical College Hospital; Malaria Research Group (MRG).038) or healthy controls (0/18, 0%; P < 0.001). The spectrum of malarial retinopathy was similar to that previously described in African children, but no vessel discolouration was observed. The severity of retinal whitening correlated with admission venous plasma