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Publication Metadata only Pre-transplant donor specific antibody and its clinical significance in kidney transplantation(2012-03-01) Duangtawan Thammanichanond; Atiporn Ingsathit; Tasanee Mongkolsuk; Sasivimol Rattanasiri; Surasak Kantachuvesiri; Chulalak Sakhonrat; Charoen Leenanupan; Suchin Worawichawong; Pimpun Kitpoka; Mahidol UniversityThe traditional method for assessing HLA antibodies in recipient serum samples is the complement-dependent cytotoxicity testing (CDC). Recently, the highly sensitive microbead-based Luminex assay was introduced and can detect low levels of anti-HLA... Abs. Objective: To determine the impact of pre-transplant donor-specific HLA antibodies (DSA) detectable by Luminex, despite a negative CDC crossmatch, on the outcomes of kidney transplantation. The correlation and cut-off value of panel reactivePublication Open Access Mineral metabolism and outcomes in chronic kidney disease stage 2–4 patients(2013) Kamonwan Chartsrisak; Kotcharat Vipattawat; Montira Assanatham; Arkom Nongnuch; Atiporn Ingsathit; Somnuek Domrongkitchaiporn; Vasant Sumethkul; Sinee Distha-Banchong; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Division of NephrologyBackground: Marked hyperphosphatemia, hyperparathyroidism and 25-hydroxyvitamin D deficiency are associated with mortality in dialysis patients. Such data in chronic kidney disease stage 2–4 population are limited. It has been suggested that high... renal disease and mortality in stage 2–4 chronic kidney disease patients. Methods: This is a prospective cohort study that included 466 non-dialysis chronic kidney disease stage 2–4 patients. Mineral parameters were obtained at the time of enrollmentPublication Open Access A simplified clinical prediction score of chronic kidney disease: A cross-sectional-survey study(2011) Ammarin Thakkinstian; Atiporn Ingsathit; Amnart Chaiprasert; Sasivimol Rattanasiri; Pornpen Sangthawan; Pongsathorn Gojaseni; Kriwiporn Kiattisunthorn; Leena Ongaiyooth; Prapaipim Thirakhupt; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Section for Clinical Epidemiology and Biostatistics-sectional survey study was conducted. Ten provinces and 20 districts were stratified-cluster randomly selected across four regions in Thailand and Bangkok. The outcome of interest was chronic kidney disease stage I to V versus non-CKD. Logistic regression... score. Results: Three-thousand, four-hundred and fifty-nine subjects were included to derive the prediction scores. Four (i.e., age, diabetes, hypertension, and history of kidney stones) were significantly associated with the CKD. Total scores rangedPublication Open Access Comparison of Machine Learning With Logistic Regression for Prediction of Chronic Kidney Disease in the Thai Adult Population(2021) Ratchainant Thammasudjarit; Punnathorn Ingsathit; Sigit Ari Saputro; Atiporn Ingsathit; Ammarin Thakkinstian; รัตน์ชัยนันท์ ธรรมสุจริต; ปัณณธร อิงค์สาธิต; ซิจิต อาริ ซาปูโตร; อติพร อิงค์สาธิต; อัมรินทร์ ทักขิญเสถียร; Mahidol University. Department of Clinical Epidemiology and Biostatistics. Faculty of Medicine Ramathibodi HospitalBackground: Chronic kidney disease (CKD) takes huge amounts of resources for treatments. Early detection of patients by risk prediction model should be useful in identifying risk patients and providing early treatments Objective: To compare... the performance of traditional logistic regression with machine learning (ML) in predicting the risk of CKD in Thai population. Methods: This study used Thai Screening and Early Evaluation of Kidney Disease (SEEK) data. Seventeen features were firstly consideredPublication Open Access Prognostic factors of all-cause mortalities in continuous ambulatory peritoneal dialysis: a cohort study(2013) Phisitt Vejakama; Ammarin Thakkinstian; Atiporn Ingsathit; Prateep Dhanakijcharoen; Attia, John; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Section for Clinical Epidemiology and BiostatisticsBackground: The role of small solute clearance on mortalities in patients with CAPD has been controversial. We therefore conducted a study with 3 years' follow up in adult patients who participated in the CAPD-first policy. Methods: There were 11,523 patients with end-stage renal disease who participated in the CAPD-first policy between 2008 and 2011. Among them, 1,177 patients were included in the retrospective cohort study. A receiver operating characteristic curve was applied to calibrate the cutoffs of tKt/V, rKt/V and tCrcl. Kaplan-Meier and Cox-regression models with time varying covariates were applied to estimate overall death rate, probability of death and prognosis, respectively. Results: The cutoffs of rKt/V and tKt/V were 0.25 and 1.75, respectively. The Cox regression suggested that the higher these clearance parameters, the lower the risks of death after adjusting for covariables. The risks of death for those above these cutoffs were 57% (HR = 0.43, 95% CI: 0.31, 0.60) and 29% (HR = 0.71, 95% CI: 0.52, 0.98) lower for rKt/V and tKt/V, respectively. Age, serum albumin, hemoglobin, systolic blood pressure, and ultra-filtration volume significantly affected the mortality outcome. Conclusions: Our study suggested that the cutoffs of 0.25 and 1.75 for rKt/V and tKt/V might be associated with mortality in CAPD patients. A minimum tKt/V of 1.75 should be targeted, but increased dialysis dosage to achieve tKt/V > 2.19 adds no further benefit. Serum albumin, hemoglobin, SBP, and UF volume are also associated with mortality. However, our study may face with selection and other unobserved confounders, so further randomized controlled trials are required to confirm these cutoffs.