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Author: Chase Ridenour

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    Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites
    (2016-01-29) Patrath Ponsuwanna; Theerarat Kochakarn; Duangkamon Bunditvorapoom; Krittikorn Kümpornsin; Thomas D. Otto; Chase Ridenour; Kesinee Chotivanich; Prapon Wilairat; Nicholas J. White; Olivo Miotto; Thanat Chookajorn; Mahidol University; Faculty of Medicine, Siriraj Hospital, Mahidol University; Wellcome Trust; Nuffield Department of Clinical Medicine; Wellcome Trust Sanger Institute; University of Oxford
    processing machineries within Plasmodium species, and with the representatives of Apicomplexan species with various host tropisms, were created. Genetic variants were mapped onto existing three-dimensional structures. Genome-wide single nucleotide... in every Apicomplexan species. Haemoglobin-specific falcipains are separated from invasion-related falcipain, and their expansions within one specific locus arose independently in both P. falciparum and P. vivax lineages. Gene conversion between P
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    PublicationOpen Access
    Comparative genome‑wide analysis and evolutionary history of haemoglobin‑processing and haem detoxification enzymes in malarial parasites
    (2016) Patrath Ponsuwanna; Theerarat Kochakarn; Duangkamon Bunditvorapoom; Krittikorn Kümpornsin; Otto, Thomas D.; Chase Ridenour; Kesinee Chotivanich; Prapon Wilairat; White, Nicholas J.; Olivo Miotto; Thanat Chookajorn; Mahidol University. Faculty of Tropical Medicine. Genomic and Evolutionary Medicine Unit, Centre of Excellence in Malaria
    within Plasmodium species, and with the representatives of Apicomplexan species with various host tropisms, were created. Genetic variants were mapped onto existing three-dimensional structures. Genome-wide single nucleotide polymorphism data were used.... reichenowi lineage. Expansion of haemoglobin-specific plasmepsins occurred after the separation event of Plasmodium species, but the other members of the plasmepsin family were evolutionarily conserved with one copy for each sub-group in every Apicomplexan