1 results
Search Results
Now showing 1 - 1 of 1
Publication Metadata only Characterization of T-Cell Responses to SMX and SMX-NO in Co-Trimoxazole Hypersensitivity Patients Expressing HLA-B*13:01(2021-04-29) Jirawat Pratoomwun; Paul Thomson; Kanoot Jaruthamsophon; Rawiporn Tiyasirichokchai; Pimonpan Jinda; Ticha Rerkpattanapipat; Wichittra Tassaneeyakul; Nontaya Nakkam; Pawinee Rerknimitr; Jettanong Klaewsongkram; Yuttana Srinoulprasert; Munir Pirmohamed; Dean J. Naisbitt; Chonlaphat Sukasem; Ramathibodi Hospital; Siriraj Hospital; Chulalongkorn University; Faculty of Medicine, Khon Kaen University; University of Liverpool; Faculty of Medicine Ramathibodi Hospital, Mahidol University; Huachiew Chalermprakiet University; Prince of Songkla University; Faculty of Medicine, Chulalongkorn Universitysyndrome or drug reaction with eosinophilia and systemic symptoms. Two of the patients carried the HLA allele of interest, namely HLA-B*13:01. Sulfamethoxazole and nitroso sulfamethoxazole specific T cell clones were generated from T cell lines of co...-trimoxazole hypersensitive HLA-B*13:01-positive patients. Clones were characterized for antigen specificity and cross-reactivity with structurally related compounds by measuring proliferation and cytokine release. Surface marker expression was characterized