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Author: Dondorp, Arjen M.

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Now showing 1 - 6 of 6
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    PublicationOpen Access
    Use of a rapid test to assess plasma Plasmodium falciparum HRP2 and guide management of severe febrile illness
    (2015) Ipsita Sinha; Nattwut Ekapirat; Dondorp, Arjen M.; Woodrow, Charles J.; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit (MORU)
    Background: Plasma Plasmodium falciparum histidine-rich protein-2 (PfHRP2) is the most accurate biomarker for severe malaria, but its measurement by ELISA has been considered too unwieldy to incorporate into clinical management. Methods: Plasma... to ELISA and acceptable limits of agreement. Three different dilutions of a well characterized set of admission samples from uncomplicated and severe malaria patients studied in a low transmission setting gave an area under the receiver operator
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    PublicationOpen Access
    Coma in fatal adult human malaria is not caused by cerebral oedema
    (2011-09-17) Medana, Isabelle M.; Day, Nicholas P.J.; Navakanit Sachanonta; นวขนิษฐ์ สัจจานนท์; Mai, Nguyen T.H.; Dondorp, Arjen M.; Emsri Pongponratn; เอี่ยมศรี พงศ์พนรัตน์; Hien, Tran T.; White, Nicholas J.; Turner, Gareth D.H.; Turner, Gareth D.H.; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Research Unit.; Mahidol University. Faculty of Tropical Medicine. Department of Tropical Pathology.
    BACKGROUND: The role of brain oedema in the pathophysiology of cerebral malaria is controversial. Coma associated with severe Plasmodium falciparum malaria is multifactorial, but associated with histological evidence of parasitized erythrocyte... (P = .02). CONCLUSIONS: Histological evidence of cerebral oedema or immunohistochemical evidence of localised loss of vascular integrity did not correlate with the occurrence of pre-mortem coma in adults with fatal falciparum malaria. Enhanced
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    PublicationOpen Access
    Exploring health practitioners’ acceptability of a prospective semi‑quantitative pfHRP2 device to define severe malaria in the Democratic Republic of Congo
    (2015) Haan, Freek de; Onyamboko, Marie A.; Fanello, Caterina I.; Woodrow, Charles J.; Yoel Lubell; Boon, Wouter P. C.; Dondorp, Arjen M.; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit
    Background: A rapid diagnostic tool is being developed to discern severely ill children with severe malaria from children who are ill with alternative febrile diseases but have coincidental peripheral blood parasitaemia. The device semi...-quantitatively measures plasma pfHRP2 and has the potential to reduce mortality in children with severe febrile illnesses by improving diagnosis. The aim of this study is to identify contributing and inhibiting factors that affect healthcare practitioners
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    PublicationOpen Access
    The role of previously unmeasured organic acids in the pathogenesis of severe malaria
    (2015) Herdman, M. Trent; Natthida Sriboonvorakul; Leopold, Stije J.; Sam Douthwaite; Sanjib Mohanty; M. Mahtab Uddin Hassan; Maude, Richard J.; Kingston, Hugh WF; Katherine Plewes; Prakaykaew Charunwatthana; Kamolrat Silamut; Woodrow, Charles J.; Kesinee Chotinavich; Hossain, Md. Amir; Faiz, M. Abul; Saroj Mishra; Natchanun Leepipatpiboon; White, Nicholas J.; Day, Nicholas PJ; Joel Tarning; Dondorp, Arjen M.; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit
    Introduction: Severe falciparum malaria is commonly complicated by metabolic acidosis. Together with lactic acid (LA), other previously unmeasured acids have been implicated in the pathogenesis of falciparum malaria. Methods: In this prospective... study, we characterised organic acids in adults with severe falciparum malaria in India and Bangladesh. Liquid chromatography-mass spectrometry was used to measure organic acids in plasma and urine. Patients were followed until recovery or death
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    PublicationOpen Access
    Performance of C-reactive protein and procalcitonin to distinguish viral from bacterial and malarial causes of fever in Southeast Asia
    (2015) Yoel Lubell; Blacksell, Stuart D.; Susanna Dunachie; Ampai Tanganuchitcharnchai; Thomas Althaus; Wanitda Watthanaworawit; Paris, Daniel H.; Mayfong Mayxay; Peto, Thomas J.; Dondorp, Arjen M.; White, Nicholas J.; Day, Nicholas P.J.; François Nosten; Newton, Paul N.; Paul Turner; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit (MORU)
    Background: Poor targeting of antimicrobial drugs contributes to the millions of deaths each year from malaria, pneumonia, and other tropical infectious diseases. While malaria rapid diagnostic tests have improved use of antimalarial drugs... common viral and bacterial infections in malaria endemic settings of Southeast Asia. Methods: Serum procalcitonin and CRP levels were measured in stored serum samples from febrile patients enrolled in three prospective studies conducted in Cambodia
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    PublicationOpen Access
    Sequence variation does not confound the measurement of plasma PfHRP2 concentration in African children presenting with severe malaria
    (2012-08-16) Thiranut Ramutton; Hendriksen, Ilse CE; Mwanga-Amumpaire, Juliet; Mtove, George; Olaosebikan, Rasaq; Tshefu, Antoinette K.; Onyamboko, Marie A.; Karema, Corine; Maitland, Kathryn; Gomes, Ermelinda; Gesase, Samwel; Reyburn, Hugh; Kamolrat Silamut; Kesinee Chotivanich; เกศินี โชติวานิช; Kamoltip Promnares; Fanello, Caterina I.; Seidlein, Lorenz von; Day, Nicholas P.J.; White, Nicholas J.; Dondorp, Arjen M.; Mallika Imwong; มัลลิกา อิ่มวงศ์; Woodrow, Charles J.; Woodrow, Charles J.; Mahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical Medicine.; Mahidol University. Faculty of Tropical Medicine. Department of Molecular Tropical Medicine and Genetics.; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit.
    BACKGROUND: Plasmodium falciparum histidine-rich protein PFHRP2 measurement is used widely for diagnosis, and more recently for severity assessment in falciparum malaria. The Pfhrp2 gene is highly polymorphic, with deletion of the entire gene... countries contributing to the largest hospital-based severe malaria trial (AQUAMAT). The quantitative relationship between sequence polymorphism and PFHRP2 plasma concentration was examined in samples from selected sites in Mozambique and Tanzania