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Author: Hemmes S.N.T.

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    Association of intraoperative end-tidal CO2 levels with postoperative outcomes: a patient-level analysis of two randomised clinical trials
    (2025-01-01) Nasa P.; van Meenen D.M.P.; Paulus F.; Ferrando C.; Bluth T.; Gama de Abreu M.; Ball L.; Bossers S.M.; Schober P.; Schultz M.J.; Serpa Neto A.; Hemmes S.N.T.; Campos N.S.; Bluth T.; Hemmes S.N.T.; Librero J.; Pozo N.; Ferrando C.; Ball L.; Mazzinari G.; Pelosi P.; Gama de Abreu M.; Schultz M.J.; Neto A.S.; Hemmes S.N.T.; Gama de Abreu M.; Severgnini P.; Hollmann M.W.; Binnekade J.M.; Wrigge H.; Canet J.; Hiesmayr M.; Schmid W.; Tschernko E.; Jaber S.; Hedenstierna G.; Putensen C.; Pelosi P.; Schultz M.J.; Marti A.; Bacuzzi A.; Brodhun A.; Molin A.; Merten A.; Parera A.; Brunelli A.; Cortegiani A.; Güldner A.; Reske A.W.; Gratarola A.; Giarratano A.; Bastin B.; Heyse B.; Mazul-Sunko B.; Amantea B.; Barberis B.; Putensen C.; Uhlig C.; Marín C.M.; Celentano C.; La Bella D.; D'Antini D.; Velghe D.; Sulemanji D.; De Robertis E.; Hartmann E.; Montalto F.; Tropea F.; Mills G.H.; Cinnella G.; Della Rocca G.; Caggianelli G.; Pellerano G.; Mollica G.; Bugedo G.; Wrigge H.; Mulier J.P.; Vandenbrande J.; Geib J.; Yaqub J.; Florez J.; Mayoral J.F.; Sprung J.; Van Limmen J.; Bos L.D.J.; de Baerdemaeker L.; Jamaer L.; Spagnolo L.; Strys L.; Gil M.G.; Gama de Abreu M.; Vidal Melo M.F.; Schultz M.J.; Unzueta M.C.; Moral M.V.; Ferner M.; Hollmann M.W.; Weiss M.; Vanoni M.; Schaefer M.S.; Nasa P.; Mahidol University
    Background: The relationship between intraoperative end-tidal CO2 (etCO2) levels and postoperative outcomes remains unclear. We conducted a post hoc analysis of two randomised trials in adults undergoing major surgery under... general anaesthesia. Methods: We re-analysed individual participant data comparing high or low positive end-expiratory pressure with low tidal volume intraoperative ventilation using a merged database derived from two randomised trials in non-obese
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    Associations of intraoperative end–tidal CO2 levels with postoperative outcome–secondary analysis of a worldwide observational study
    (2025-02-01) Nasa P.; van Meenen D.M.P.; Paulus F.; de Abreu M.G.; Bossers S.M.; Schober P.; Schultz M.J.; Neto A.S.; Hemmes S.N.T.; Kroell W.; Metzler H.; Struber G.; Wegscheider T.; Gombotz H.; Hiesmayr M.; Schmid W.; Urbanek B.; Kahn D.; Momeni M.; Pospiech A.; Lois F.; Forget P.; Grosu I.; Poelaert J.; van Mossevelde V.; van Malderen M.C.; Dylst D.; van Melkebeek J.; Beran M.; de Hert S.; De Baerdemaeker L.; Heyse B.; Van Limmen J.; Wyffels P.; Jacobs T.; Roels N.; De Bruyne A.; van de Velde S.; Leva B.; Damster S.; Plichon B.; JurosZovko M.; Djonovic-Omanoviċ D.; Pernar S.; Zunic J.; Miskovic P.; Zilic A.; Kvolik S.; Ivic D.; Azenic-Venzera D.; Skiljic S.; Vinkovic H.; Oputric I.; Juricic K.; Frkovic V.; Kopic J.; Mirkovic I.; Karanovic N.; Carev M.; Dropulic N.; Saric J.P.; Erceg G.; Dvorscak M.B.; Mazul-Sunko B.; Pavicic A.M.; Goranovic T.; Maldini B.; Radocaj T.; Gavranovic Z.; Mladic-Batinica I.; Sehovic M.; Stourac P.; Harazim H.; Smekalova O.; Kosinova M.; Kolacek T.; Hudacek K.; Drab M.; Brujevic J.; Vitkova K.; Jirmanova K.; Volfova I.; Dzurnakova P.; Liskova K.; Dudas R.; Filipsky R.; El Kafrawy S.; Abdelwahab H.H.; Metwally T.; Abdel-Razek A.; El-Shaarawy A.M.; Hasan W.F.; Ahmed A.G.; Yassin H.; Magdy M.; Abdelhady M.; Mahran M.; Herodes E.; Kivik P.; Oganjan J.; Nasa P.; Mahidol University
    Background: Patients receiving intraoperative ventilation during general anesthesia often have low end–tidal CO2 (etCO2). We examined the association of intraoperative etCO2 levels with the occurrence of postoperative pulmonary complications (PPCs...) in a conveniently–sized international, prospective study named ‘Local ASsessment of Ventilatory management during General Anesthesia for Surgery’ (LAS VEGAS). Methods: Patients at high risk of PPCs were categorized as ‘low etCO2’ or ‘normal to high etCO