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Publication Metadata only Opposite malaria and pregnancy effect on oral bioavailability of artesunate - A population pharmacokinetic evaluation(2015-10-01) Frank Kloprogge; Rose McGready; Aung Pyae Phyo; Marcus J. Rijken; Warunee Hanpithakpon; Hla Hla Than; Nathar Hlaing; Naw Thida Zin; Nicholas P.J. Day; Nicholas J. White; François Nosten; Joel Tarning; University of Oxford; Mahidol Universityin the same women: i) pregnant with acute uncomplicated malaria on day 1 and 2, ii) pregnant with convalescent malaria on day 7 and iii) in a healthy state 3 months post-partum on day 1, 2 and 7. Methods Non-linear mixed-effects modelling was used to compare... and 15 volunteered to be restudied 3 months post-partum. Malaria and pregnancy had no effect on the pharmacokinetic properties of artesunate or dihydroartemisinin after intravenous artesunate administration. However, malaria and pregnancy had oppositePublication Metadata only Population pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and nonpregnant women with uncomplicated malaria(2012-04-01) Joel Tarning; Marcus J. Rijken; Rose McGready; Aung Pyae Phyo; Warunee Hanpithakpong; Nicholas P J Day; Nicholas J. White; François Nosten; Niklas Lindegardh; Mahidol University; Nuffield Department of Clinical Medicine; Shoklo Malaria Research Unittreated with a standard fixed oral 3-day treatment, and venous plasma concentrations of both drugs were measured frequently for pharmacokinetic evaluation. Population pharmacokinetics were evaluated with nonlinear mixed-effects modeling. The main... of this study was to evaluate the population pharmacokinetic properties of piperaquine and dihydroartemisinin in pregnant and nonpregnant women with uncomplicated malaria. Twenty-four pregnant and 24 matched nonpregnant women on the Thai-Myanmar boarder werePublication Metadata only Population pharmacokinetic assessment of the effect of food on piperaquine bioavailability in patients with uncomplicated malaria(2014-01-01) Joel Tarning; Niklas Lindegardh; Khin Maung Lwin; Anna Annerberg; Lily Kiricharoen; Elizabeth Ashley; Nicholas J. White; François Nosten; Nicholas P.J. Day; Mahidol University; Nuffield Department of Clinical MedicinePlasmodium falciparum malaria in Thailand. Nonlinear mixed-effects modeling was used to characterize the pharmacokinetics of piperaquine and the influence of concomitant food intake. A modified Monte Carlo mapped power approach was applied to evaluate... in the final model. The novel power approach concluded that the study was adequately powered to detect a food effect of at least 35%. This modified Monte Carlo mapped power approach may be a useful tool for evaluating the power to detect true covariate effectsPublication Metadata only Statistical power calculations for mixed pharmacokinetic study designs using a population approach(2014-01-01) Frank Kloprogge; Julie A. Simpson; Nicholas P.J. Day; Nicholas J. White; Joel Tarning; Mahidol University; Nuffield Department of Clinical Medicine; University of Melbourne) a model not including the covariate effect in NONMEM 7.2. Power calculations were performed for varying numbers of patients with sampling designs A and B. Study designs with statistical power >80% were selected and further evaluated for cost...-effectiveness. The simulation studies of the hypothetical drug and the anti-malarial drug dihydroartemisinin demonstrated that the simulation-based power calculation methodology, based on the Monte Carlo Mapped Power method, can be utilised to evaluatePublication Metadata only Population pharmacokinetic and pharmacodynamic properties of artesunate in patients with artemisinin sensitive and resistant infections in Southern Myanmar(2018-03-23) Jesmin Permala Lohy Das; Myat P. Kyaw; Myat H. Nyunt; Khin Chit; Kyin H. Aye; Moe M. Aye; Mats O. Karlsson; Martin Bergstrand; Joel Tarning; Mahidol University; Nuffield Department of Clinical Medicine; Uppsala Universitet/kg) for 7 days. Frequent artesunate and dihydroartemisinin plasma concentration measurements and parasite microscopy counts were obtained and evaluated using nonlinear mixed-effects modelling. Results: The absorption of artesunate was best...© 2018 The Author(s). Background: Artemisinins are the most effective anti-malarial drugs for uncomplicated and severe Plasmodium falciparum malaria. However, widespread artemisinin resistance in the Greater Mekong Region of Southeast AsiaPublication Open Access Population pharmacokinetic properties of artemisinin in healthy male Vietnamese volunteers(2016) Sofia Birgersson; Pham Van Toi; Nguyen Thanh Truong; Nguyen Thi Dung; Michael Ashton; Tran Tinh Hien; Angela Abelö; Joel Tarning; Mahidol University. Faculty of Tropical Medicine. Mahidol‑Oxford Tropical Medicine Research Unitto 12 h after dose in each period. Artemisinin was quantified in plasma using liquid chromatography coupled with tandem mass spectrometry. A nonlinear mixed-effects modelling approach was utilized to evaluate the population pharmacokinetic properties... properties of artemisinin. The results from the traditional bioequivalence evaluation were comparable with results obtained from mixed-effects modellingPublication Metadata only Population pharmacokinetic properties of artemisinin in healthy male Vietnamese volunteers(2016-02-16) Sofia Birgersson; Pham Van Toi; Nguyen Thanh Truong; Nguyen Thi Dung; Michael Ashton; Tran Tinh Hien; Angela Abelö; Joel Tarning; Göteborgs Universitet; University of Oxford; UCL; Nuffield Department of Clinical Medicine; Mahidol Universityfrequently up to 12 h after dose in each period. Artemisinin was quantified in plasma using liquid chromatography coupled with tandem mass spectrometry. A nonlinear mixed-effects modelling approach was utilized to evaluate the population pharmacokinetic... properties of artemisinin. The results from the traditional bioequivalence evaluation were comparable with results obtained from mixed-effects modelling.Publication Metadata only Adherence and Population Pharmacokinetic Properties of Amodiaquine When Used for Seasonal Malaria Chemoprevention in African Children(2020-05-01) Junjie Ding; Matthew E. Coldiron; Bachir Assao; Ousmane Guindo; Daniel Blessborn; Markus Winterberg; Rebecca F. Grais; Alena Koscalova; Celine Langendorf; Joel Tarning; Children’s Hospital of Fudan University; Epicentre; Mahidol University; Nuffield Department of Clinical Medicine; Medecins Sans Frontieres; WorldWide Antimalarial Resistance Networkthe protective effectiveness of SMC. Here, we evaluated the population pharmacokinetic properties of amodiaquine and its active metabolite, desethylamodiaquine, in children receiving SMC under directly observed ideal conditions (n = 136), and the adherence of SMC... at an implementation phase in children participating in a case-control study to evaluate SMC effectiveness (n = 869). Amodiaquine and desethylamodiaquine concentration-time profiles were described simultaneously by two-compartment and three-compartment dispositionPublication Metadata only Piperaquine concentration and malaria treatment outcomes in Ugandan children treated for severe malaria with intravenous Artesunate or quinine plus Dihydroartemisinin-Piperaquine(2019-12-03) Pauline Byakika-Kibwika; Ronald Ssenyonga; Mohammed Lamorde; Daniel Blessborn; Joel Tarning; Makerere University; Mahidol University; Nuffield Department of Clinical Medicine; Infectious Diseases Institutebe completed with effective artemisinin based combination therapy (ACT) for complete parasite clearance and to prevent recrudescence. We evaluated piperaquine concentration and malaria treatment outcomes among Ugandan children treated for severe malaria...© 2019 The Author(s). Background: Treatment for severe malaria must be prompt with effective parenteral antimalarial drugs for at least 24 h to achieve fast parasite clearance, and when the patient can tolerate oral therapy, treatment shouldPublication Metadata only Screening of phytochemicals and in vitro evaluation of antibacterial and antioxidant activities of leaves, pods and bark extracts of Acacia nilotica (L.) Del.(2015-09-01) Muhammad Bilal Sadiq; Warunee Hanpithakpong; Joel Tarning; Anil Kumar Anal; Asian Institute of Technology Thailand; Mahidol University; Nuffield Department of Clinical Medicine© 2015 Elsevier B.V.. The objective of this study was to determine the phytochemical content, antibacterial activity and antioxidant activity of leaves, bark and pods of Acacia nilotica. The different extracts of acacia were evaluated for total..., were effective in inhibiting the growth of antibiotic resistant strains of Escherichia coli and Salmonella species obtained from clinical and food isolates. The leaves were found to be rich in total phenolic content, proteins and high antioxidant