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Publication Open Access Population pharmacokinetic properties of artemisinin in healthy male Vietnamese volunteers(2016) Sofia Birgersson; Pham Van Toi; Nguyen Thanh Truong; Nguyen Thi Dung; Michael Ashton; Tran Tinh Hien; Angela Abelö; Joel Tarning; Mahidol University. Faculty of Tropical Medicine. Mahidol‑Oxford Tropical Medicine Research Unitwith uncomplicated Plasmodium falciparum infections. The aim of this study was to characterize the population pharmacokinetic properties of artemisinin in healthy male Vietnamese volunteers after two different dose sizes, formulations and in a combination... to 12 h after dose in each period. Artemisinin was quantified in plasma using liquid chromatography coupled with tandem mass spectrometry. A nonlinear mixed-effects modelling approach was utilized to evaluate the population pharmacokinetic propertiesPublication Metadata only Population pharmacokinetic properties of artemisinin in healthy male Vietnamese volunteers(2016-02-16) Sofia Birgersson; Pham Van Toi; Nguyen Thanh Truong; Nguyen Thi Dung; Michael Ashton; Tran Tinh Hien; Angela Abelö; Joel Tarning; Göteborgs Universitet; University of Oxford; UCL; Nuffield Department of Clinical Medicine; Mahidol Universityin patients with uncomplicated Plasmodium falciparum infections. The aim of this study was to characterize the population pharmacokinetic properties of artemisinin in healthy male Vietnamese volunteers after two different dose sizes, formulations and in a... frequently up to 12 h after dose in each period. Artemisinin was quantified in plasma using liquid chromatography coupled with tandem mass spectrometry. A nonlinear mixed-effects modelling approach was utilized to evaluate the population pharmacokineticPublication Metadata only Population pharmacokinetic modeling of tribendimidine metabolites in Opisthorchis viverrini-infected adults(2016-10-01) Fiona Vanobberghen; Melissa A. Penny; Urs Duthaler; Peter Odermatt; Somphou Sayasone; Jennifer Keiser; Joel Tarning; Swiss Tropical and Public Health Institute (Swiss TPH); Universitat Basel; National Institute of Public Health; Mahidol University; Nuffield Department of Clinical Medicine; University of Basel, Institute for Medical MicrobiologyCopyright © 2016 Vanobberghen et al. There is a pressing need for alternative treatments against the liver fluke Opisthorchis viverrini. Oral tribendimidine is a promising candidate, but its population pharmacokinetic properties are unknown. Two... whole blood, plasma, and capillary dried blood spots were sampled frequently from 68 adults, and concentrations of the tribendimidine metabolites dADT (deacetylated amidantel) and adADT (acetylated dADT) were measured. Population pharmacokinetics werePublication Metadata only Optimization of dosing regimens of isoniazid and rifampicin in children with tuberculosis in India(2019-03-01) Blessed Winston Aruldhas; Richard M. Hoglund; Jaya Ranjalkar; Joel Tarning; Sumith K. Mathew; Valsan Philip Verghese; Anuradha Bose; Binu Susan Mathew; Mahidol University; Nuffield Department of Clinical Medicine; Christian Medical College, Vellorewith a transit absorption model (fixed, n = 5). A mixture model was used to identify the slow and fast acetylator subgroups. Rifampicin was described by a one-compartment disposition model with a transit absorption model (fixed, n = 9). Body weight... was added to the clearance and volume of distribution of both the drugs using an allometric function. Simulations with the isoniazid model showed that 84.9% of the population achieved therapeutic peak serum concentration with the planned fixed-dosePublication Metadata only Pooled population pharmacokinetic analysis of tribendimidine for the treatment of opisthorchis viverrini infections(2019-04-01) Isabel Meister; Piyanan Assawasuwannakit; Fiona Vanobberghen; Melissa A. Penny; Peter Odermatt; Somphou Sayasone; Jörg Huwyler; Joel Tarning; Jennifer Keiser; Universitat Basel; Swiss Tropical and Public Health Institute (Swiss TPH); Mahidol University; Nuffield Department of Clinical Medicine; Ministry of Healthpharmacokinetic data were described using a flexible transit absorption model for the active metabolite dADT, followed by one-compartment disposition models for both metabolites. Significant covariates were age, body weight, formulation, and breakingPublication Metadata only Population pharmacokinetic and pharmacodynamic properties of artesunate in patients with artemisinin sensitive and resistant infections in Southern Myanmar(2018-03-23) Jesmin Permala Lohy Das; Myat P. Kyaw; Myat H. Nyunt; Khin Chit; Kyin H. Aye; Moe M. Aye; Mats O. Karlsson; Martin Bergstrand; Joel Tarning; Mahidol University; Nuffield Department of Clinical Medicine; Uppsala Universitetcharacterized by a transit-compartment (n = 3) model, followed by one-compartment disposition models for artesunate and dihydroartemisinin. The drug-dependent parasite killing effect of dihydroartemisinin was described using an Emax function, with a mixture... model discriminating between artemisinin sensitive and resistant parasites. Overall, 56% of the studied population was predicted to have resistant malaria infections. Application of the proposed nomogram to identify artemisinin-resistant malariaPublication Metadata only Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda(2012-08-24) Joel Tarning; Frank Kloprogge; Patrice Piola; Mehul Dhorda; Sulaiman Muwanga; Eleanor Turyakira; Nitra Nuengchamnong; François Nosten; Nicholas P J Day; Nicholas J. White; Philippe J. Guerin; Niklas Lindegardh; Nuffield Department of Clinical Medicine; Mahidol University; Epicentre; Epicentre; University of Maryland School of Medicine; University of Science and Technology; Shoklo Malaria Research Unitthe pharmacokinetic properties of many anti-malarial drugs. Reduced drug exposure increases the risk of treatment failure. The objective of this study was to evaluate the population pharmacokinetic properties of artemether and its active metabolite dihydroartemisinin... lumefantrine twice daily for three days. Artemether and dihydroartemisinin plasma concentrations after the last dose administration were quantified using liquid chromatography coupled to tandem mass-spectroscopy. A simultaneous drug-metabolite populationPublication Metadata only A population pharmacokinetic model of piperaquine in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Sudan(2012-12-03) Richard M. Hoglund; Ishag Adam; Warunee Hanpithakpong; Michael Ashton; Niklas Lindegardh; Nicholas Pj Day; Nicholas J. White; Francois Nosten; Joel Tarning; Goteborgs Universitet; University of Khartoum Faculty of Medicine; Mahidol University; Churchill Hospital; Shoklo Malaria Research Unitin a decreased drug exposure. Piperaquine is a promising anti-malarial partner drug used in a fixed-dose combination with dihydroartemisinin. The aim of this study was to investigate the population pharmacokinetics of piperaquine in pregnant and non... published study to evaluate the power of detecting covariates in this relatively small study. Results: A three-compartment disposition model with a transit-absorption model described the observed data well. Body weight was added as an allometric functionPublication Metadata only Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Burkina Faso: An open label trial [version 2; peer review: 2 approved](2020-01-01) Sofia Birgersson; Innocent Valea; Halidou Tinto; Maminata Traore-Coulibaly; Laeticia C. Toe; Richard M. Hoglund; Jean Pierre Van Geertruyden; Stephen A. Ward; Umberto D’Alessandro; Angela Abelö; Joel Tarning; Universiteit Gent; London School of Hygiene & Tropical Medicine; Liverpool School of Tropical Medicine; Göteborgs Universitet; Universiteit Antwerpen; Mahidol University; Nuffield Department of Clinical Medicine; Unité de Recherche Clinique de Nanoro; Institut de Recherche en Sciences de la Santéusing a population modelling approach. Methods: Twenty-four women in their second and third trimester of pregnancy and twenty-four paired non-pregnant women, all with uncomplicated P. falciparum malaria, were enrolled in this study. Treatment was a fixed.... Results: Artesunate pharmacokinetics was best described by a transit-compartment absorption model followed by a one-compartment disposition model under the assumption of complete in vivo conversion of artesunate into dihydroartemisinin. DihydroartemisininPublication Metadata only Severe Acute Malnutrition Results in Lower Lumefantrine Exposure in Children Treated With Artemether-Lumefantrine for Uncomplicated Malaria(2019-12-01) Palang Chotsiri; Lise Denoeud-Ndam; Elisabeth Baudin; Ousmane Guindo; Halimatou Diawara; Oumar Attaher; Michiel Smit; Philippe J. Guerin; Ogobara K. Doumbo; Lubbe Wiesner; Karen I. Barnes; Richard M. Hoglund; Alassane Dicko; Jean Francois Etard; Joel Tarning; University of Bamako Faculty of Medicine, Pharmacy and Odonto-Stomatology; Epicentre; Mahidol University; Nuffield Department of Clinical Medicine; Inserm; University of Cape Town; WorldWide Antimalarial Resistance Network (WWARN)malaria morbidity in Sub-Saharan African children and may affect the pharmacology of antimalarial drugs. This population pharmacokinetic (PK)-pharmacodynamic study included 131 SAM and 266 non-SAM children administered artemether-lumefantrine twice daily... for 3 days. Lumefantrine capillary plasma concentrations were adequately described by two transit-absorption compartments followed by two distribution compartments. Allometrically scaled body weight and an enzymatic maturation effect were included