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Now showing 1 - 10 of 17

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Plasmodium falciparum pfmdrl amplification, mefloquine resistance, and parasite fitness
(2009-04-01) Piyanuch Preechapornkul; Mallika Imwong; Kesinee Chotivanich; Wirichada Pongtavornpinyo; Arjen M. Dondorp; Nicholas P J Day; Nicholas J. White; Sasithon Pukrittayakamee; Mahidol University; Churchill Hospital; Wahidnl-Oxford Tropical Medicine Research Unit
studied the ex vivo dynamics of pfmdrl gene amplification in culture-adapted P. falciparum in relation to mefloquine resistance and parasite fitness. A Thai P. falciparum isolate (isolate TM036) was assessed by the use of multiple genetic markers as a
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OSTRFPD: Multifunctional Tool for Genome-Wide Short Tandem Repeat Analysis for DNA, Transcripts, and Amino Acid Sequences with Integrated Primer Designer
(2019-04-01) Vivek Bhakta Mathema; Arjen M. Dondorp; Mallika Imwong; Churchill Hospital; Mahidol University
. Practical implementation of OSTRFPD was demonstrated using publicly available whole-genome sequences of selected Plasmodium species. OSTRFPD is freely available and open-sourced for improvement and user-specific adaptation.
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High-throughput ultrasensitive molecular techniques for quantifying low-density malaria parasitemias
(2014-01-01) Mallika Imwong; Sarun Hanchana; Benoit Malleret; Laurent Rénia; Nicholas P.J. Day; Arjen Dondorp; Francois Nosten; Georges Snounou; Nicholas J. White; Mahidol University; Agency for Science, Technology and Research, Singapore; Yong Loo Lin School of Medicine; Churchill Hospital; Sorbonne Universite; CNRS Centre National de la Recherche Scientifique
strategies, more sensitive quantitative PCR (qPCR) is needed to identify and quantify low-density malaria parasitemias. A highly sensitive "high-volume" quantitative PCR (qPCR) method based on Plasmodium sp. 18S RNA was adapted for blood sample volumes
Open Access
FlexiChip package: an universal microarray with a dedicated analysis software for high-thoughput SNPs detection linked to anti-malarial drug resistance.
(2009-10-15) Steenkeste, Nicolas; Dillies, Marie-Agnès; Khim, Nimol; Sismeiro, Odile; Chy, Sophy; Lim, Pharath; Crameri, Andreas; Bouchier, Christiane; Mercereau-Puijalon, Odile; Beck, Hans-Peter; Mallika Imwong; มัลลิกา อิ่มวงศ์; Dondorp, Arjen M.; Socheat, Duong; Rogier, Christophe; Coppée, Jean- Yves; Ariey, Frédéric; Steenkeste, Nicolas; Mahidol University. Faculty of Tropical Medicine
-nucleotide polymorphisms (SNP) associated with parasite resistance to anti-malarial drugs (ResMalChip) were adapted for a universal microarray FlexiChip format. To evaluate the overall sensitivity of the FlexiChip package (microarray + software), the results
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Investigations on anopheline mosquitoes close to the nest sites of chimpanzees subject to malaria infection in Ugandan Highlands
(2012-06-19) Sabrina Krief; Florence Levrero; Jean Michel Krief; Supinya Thanapongpichat; Mallika Imwong; Georges Snounou; John M. Kasenene; Marie Cibot; Jean Charles Gantier; Museum National d'Histoire Naturelle; Projet Pour la Conservation des Grands Singes; CNRS Centre National de la Recherche Scientifique; Mahidol University; Institut National de la Santï¿½ et de la Recherche Mï¿½dicale; Universite Pierre et Marie Curie; Makerere University; Faculté de Pharmacie. 92290 Chatenay-Malabry
adaptation that would lead to a decrease in the number of infectious bites and consequently malaria. Methods. Mosquitoes were collected over two years using suction-light traps and yeast-generated CO 2 traps at the nesting and the feeding sites of two
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A major genome region underlying artemisinin resistance in malaria
(2012-04-06) Ian H. Cheeseman; Becky A. Miller; Shalini Nair; Standwell Nkhoma; Asako Tan; John C. Tan; Salma Al Saai; Aung Pyae Phyo; Carit Ler Moo; Khin Maung Lwin; Rose McGready; Elizabeth Ashley; Mallika Imwong; Kasia Stepniewska; Poravuth Yi; Arjen M. Dondorp; Mayfong Mayxay; Paul N. Newton; Nicholas J. White; François Nosten; Michael T. Ferdig; Timothy J.C. Anderson; Texas Biomedical Research Institute; University of Notre Dame; Shoklo Malaria Research Unit; Mahidol University; Churchill Hospital; Mahosot Hospital; WorldWide Antimalarial Resistance Network; National Center for Parasitology, Entomology and Malaria Control
on chromosome 13 that shows strong association (P = 10 -6 to 10 -12 ) with slow CRs, illustrating the efficacy of targeted association for identifying the genetic basis of adaptive traits.
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FlexiChip package: An universal microarray with a dedicated analysis software for high-thoughput SNPs detection linked to anti-malarial drug resistance
(2009-11-30) Nicolas Steenkeste; Marie Agnès Dillies; Nimol Khim; Odile Sismeiro; Sophy Chy; Pharath Lim; Andreas Crameri; Christiane Bouchier; Odile Mercereau-Puijalon; Hans Peter Beck; Mallika Imwong; Arjen M. Dondorp; Duong Socheat; Christophe Rogier; Jean Yves Coppée; Frédéric Ariey; Institut Pasteur du Cambodge; Institut Pasteur, Paris; Amunix, Inc.; GENOPOLE; Swiss Tropical and Public Health Institute (Swiss TPH); Mahidol University; Centre for Clinical Vaccinology and Tropical Medicine; National Center for Parasitology, Entomology and Malaria Control; IMTSSA Institut de Medecine Tropicale du Service de Sante des Armees
-nucleotide polymorphisms (SNP) associated with parasite resistance to anti-malarial drugs (ResMalChip) were adapted for a universal microarray FlexiChip format. To evaluate the overall sensitivity of the FlexiChip package (microarray + software), the results
Metadata only
Population genetic analysis of plasmodium falciparum parasites using a customized illumina goldengate genotyping assay
(2011-06-13) Susana Campino; Sarah Auburn; Katja Kivinen; Issaka Zongo; Jean Bosco Ouedraogo; Valentina Mangano; Abdoulaye Djimde; Ogobara K. Doumbo; Steven M. Kiara; Alexis Nzila; Steffen Borrmann; Kevin Marsh; Pascal Michon; Ivo Mueller; Peter Siba; Hongying Jiang; Xin Zhuan Su; Chanaki Amaratunga; Duong Socheat; Rick M. Fairhurst; Mallika Imwong; Timothy Anderson; François Nosten; Nicholas J. White; Rhian Gwilliam; Panos Deloukas; Bronwyn MacInnis; Christopher I. Newbold; Kirk Rockett; Taane G. Clark; Dominic P. Kwiatkowski; Wellcome Trust Sanger Institute; Menzies School of Health Research; Institut de Recherche en Sciences de la Santé; Universita degli Studi di Roma La Sapienza; University of Bamako Faculty of Medicine, Pharmacy and Odonto-Stomatology; Wellcome Trust Research Laboratories Nairobi; Papua New Guinea Institute of Medical Research; Divine Word University; National Institute of Allergy and Infectious Diseases; National Center for Parasitology, Entomology and Malaria Control; Mahidol University; Texas Biomedical Research Institute; Shoklo Malaria Research Unit; John Radcliffe Hospital; Wellcome Trust Centre for Human Genetics; London School of Hygiene & Tropical Medicine
on P. falciparum DNA from laboratory clones (long-term cultured adapted parasite clones), short-term cultured parasite isolates and clinical (non-cultured isolates) samples from East and West Africa, Southeast Asia and Oceania. Eighty percent
Open Access
High-throughput ultrasensitive molecular techniques for quantifying low-density malaria parasitemias.
(2014-09) Mallika Imwong; มัลลิกา อิ่มวงศ์; Sarun Hanchana; Malleret, Benoit; Rénia, Laurent; Day, Nicholas P. J.; Dondorp, Arjen; Nosten, Francois; Snounou, Georges; White, Nicholas J.; Mallika Imwong; Mahidol University. Faculty of Tropical Medicine. Department of Molecular Tropical Medicine and Genetics.; Mahidol University. Faculty of Tropical Medicine. Mahidol Oxford Research Unit.; Mahidol University. Faculty of Tropical Medicine. Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit.
strategies, more sensitive quantitative PCR (qPCR) is needed to identify and quantify low-density malaria parasitemias. A highly sensitive "high-volume" quantitative PCR (qPCR) method based on Plasmodium sp. 18S RNA was adapted for blood sample volumes
Open Access
Population genetic analysis of Plasmodium falciparum parasites using a customized Illumina GoldenGate genotyping assay.
(2011) Campino, Susana; Auburn, Sarah; Kivinen, Katja; Zongo, Issaka; Ouedraogo, Jean-Bosco; Mangano, Valentina; Djimde, Abdoulaye; Doumbo, Ogobara K.; Kiara, Steven M.; Nzila, Alexis; Borrmann, Steffen; Marsh, Kevin; Michon, Pascal; Mueller, Ivo; Siba, Peter; Jiang, Hongying; Su, Xin-Zhuan; Chanaki Amaratunga; Socheat, Duong; Fairhurst, Rick M.; Mallika Imwong; มัลลิกา อิ่มวงศ์; Anderson, Timothy; Nosten, Francois; White, Nicholas J.; Gwilliam, Rhian; Deloukas, Panos; MacInnis, Bronwyn; Newbold, Christopher I.; Rockett, Kirk; Clark, Taane G.; Kwiatkowski, Dominic P.; Campino, Susana; Fitzgerald, J. Ross; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford University Research Unit.; Mahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical Medicine.; Mahidol University. Faculty of Tropical Medicine. Department of Molecular Tropical Medicine and Genetics.
Gate assay on P. falciparum DNA from laboratory clones (long-term cultured adapted parasite clones), short-term cultured parasite isolates and clinical (non-cultured isolates) samples from East and West Africa, Southeast Asia and Oceania. Eighty percent

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