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Publication Metadata only An open, randomized, controlled trial of penicillin, doxycycline, and cefotaxime for patients with severe leptospirosis(2004-11-15) Yupin Suputtamongkol; Kanigar Niwattayakul; Chuanpit Suttinont; Kitti Losuwanaluk; Roongroeng Limpaiboon; Wirongrong Chierakul; Vanaporn Wuthiekanun; Surapee Triengrim; Mongkol Chenchittikul; Nicholas J. White; Mahidol University; Muang Loei Ram Hospital; Maharaj Nakhon Ratchasima Hospital; Banmai Chaiyapod Hospital; Udon Thani Center Hospital; National Institutes of Health, Bethesda; Churchill Hospitalleptospirosis was conducted. The study involved 540 patients admitted to 4 hospitals in northeastern Thailand. Results. A total of 264 patients (48.9%) had leptospirosis confirmed by serologic testing or culture. The overall mortality rate was 5%. There were... no significant differences between the antibiotics with regard to associated mortality, defervescence, or time to resolution of abnormal findings of laboratory tests either among all study participants or among the subgroup of patients with confirmedPublication Metadata only Effect of hydroxychloroquine in hospitalized patients with Covid-19(2020-11-19) Peter Horby; Marion Mafham; Louise Linsell; Jennifer L. Bell; Natalie Staplin; Jonathan R. Emberson; Martin Wiselka; Andrew Ustianowski; Einas Elmahi; Benjamin Prudon; Tony Whitehouse; Timothy Felton; John Williams; Jakki Faccenda; Jonathan Underwood; J. Kenneth Baillie; Lucy C. Chappell; Saul N. Faust; Thomas Jaki; Katie Jeffery; Wei Shen Lim; Alan Montgomery; Kathryn Rowan; Joel Tarning; James A. Watson; Nicholas J. White; Edmund Juszczak; Richard Haynes; Martin J. Landray; National Institute for Health Research; North West Anglia NHS Foundation Trust; Cardiff & Vale University Health Board; Manchester University NHS Foundation Trust; Department of Mathematics and Statistics, Lancaster University; University of Cambridge; The James Cook University Hospital; University Hospitals of Leicester NHS Trust; University of Oxford; University Hospitals Birmingham NHS Foundation Trust; University of Edinburgh, Roslin Institute; Nottingham University Hospitals NHS Trust; Northampton General Hospital; North Tees and Hartlepool NHS Foundation Trust; Medical Research Council; University of Nottingham; Mahidol University; King's College London; Nuffield Department of Medicine; North Manchester General Hospital; The University of Manchester; University of Oxford Medical Sciences Division; University Hospital Southampton NHS Foundation Trust; Intensive Care National Audit and Research Centre, randomized trials. METHODS In this randomized, controlled, open-label platform trial comparing a range of possible treatments with usual care in patients hospitalized with Covid-19, we randomly assigned 1561 patients to receive hydroxychloroquine and 3155.... The results suggest that patients in the hydroxychloroquine group were less likely to be discharged from the hospital alive within 28 days than those in the usual-care group (59.6% vs. 62.9%; rate ratio, 0.90; 95% CI, 0.83 to 0.98). Among the patients who werePublication Metadata only Epidemiological characteristics, ventilator management, and clinical outcome in patients receiving invasive ventilation in intensive care units from 10 Asian middle-income countries (PRoVENT-iMiC): An international, multicenter, prospective study(2021-03-01) Luigi Pisani; Anna Geke Algera; Ary Serpa Neto; Areef Ahsan; Abigail Beane; Kaweesak Chittawatanarat; Abul Faiz; Rashan Haniffa; Seyed Mohammad Reza Hashemian; Madiha Hashmi; Hisham Ahmed Imad; Kanishka Indraratna; Shivakumar Iyer; Gyan Kayastha; Bhuvana Krishna; Tai Li Ling; Hassan Moosa; Behzad Nadjm; Rajyabardhan Pattnaik; Sriram Sampath; Louise Thwaites; Ni Ni Tun; Norazim Mohd Yunos; Salvatore Grasso; Frederique Paulus; Marcelo Gama de Abreu; Paolo Pelosi; Nick Day; Nicholas J. White; Arjen M. Dondorp; Marcus J. Schultz; Universitätsklinikum Carl Gustav Carus Dresden; Faculty of Tropical Medicine, Mahidol University; Oxford University Clinical Research Unit; IRCCS San Martino Polyclinic Hospital; Bharati Vidyapeeth Medical College, Pune; Indira Gandhi Memorial Hospital Male; Sri Jayewardenepura General Hospital; Ispat General Hospital; The Aga Khan University; Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders; Kuala Lumpur Hospital; Università degli Studi di Genova; Università degli studi di Bari Aldo Moro; Shahid Beheshti University of Medical Sciences; Hospital Israelita Albert Einstein; University of Malaya Medical Centre; Nuffield Department of Medicine; Amsterdam UMC - University of Amsterdam; Chiang Mai University; 19Medical Action Myanmar; St. John’s Medical College; Dev Care Foundation; Patan Academy of Health SciencesEpidemiology, ventilator management, and outcome in patients receiving invasive ventilation in intensive care units (ICUs) in middle-income countries are largely unknown. PRactice of VENTilation in Middle-income Countries is an international... multicenter 4-week observational study of invasively ventilated adult patients in 54 ICUs from 10 Asian countries conducted in 2017/18. Study outcomes included major ventilator settings (including tidal volume [VT] and positive end-expiratory pressure [PEEPPublication Metadata only A randomized controlled trial of granulocyte colony-stimulating factor for the treatment of severe sepsis due to melioidosis in Thailand(2007-08-01) Allen C. Cheng; Direk Limmathurotsakul; Wirongrong Chierakul; Nongluk Getchalarat; Vanaporn Wuthiekanun; Dianne P. Stephens; Nicholas P.J. Day; Nicholas J. White; Wipada Chaowagul; Bart J. Currie; Sharon J. Peacock; Menzies School of Health Research; Royal Darwin Hospital; Mahidol University; Sappasitthiprasong Hospital; John Radcliffe Hospital; University of Melbourneof lenograstim (granulocyte colony-stimulating factor [G-CSF], 263 μg per day administered intravenously) in ceftazidime-treated patients with severe sepsis caused by suspected melioidosis in Thailand. Results. Over a 27-month period, 60 patients were enrolled... to receive either G-CSF (30 patients, 18 of whom had culture-confirmed melioidosis) or placebo (30 patients, 23 of whom had culture-confirmed melioidosis). Mortality rates were similar in both groups (G-CSF group, 70%; placebo group, 87%; risk ratio, 0.81; 95Publication Metadata only Melioidosis in 6 tsunami survivors in Southern Thailand(2005-10-01) Wirongrong Chierakul; Wut Winothai; Charnkij Wattanawaitunechai; Vanaporn Wuthiekanun; Thaweesak Rugtaengan; Jurairat Rattanalertnavee; Pornlert Jitpratoom; Wipada Chaowagul; Pratap Singhasivanon; Nicholas J. White; Nicholas P. Day; Sharon J. Peacock; Mahidol University; Takuapa General Hospital; Sappasitthiprasong Hospital; Nuffield Department of Clinical Medicine(median duration, 1 day) between aspiration and onset of pneumonia; were more likely to exhibit shock, respiratory failure, renal failure, and/or altered consciousness (P = .03); and had a higher in-hospital mortality (64% [ 14 of 22 patients]; P = .07...Background. Six cases of melioidosis were identified in survivors of the 26 December 2004 tsunami who were admitted to Takuapa General Hospital in Phangnga, a region in southern Thailand where melioidosis is not endemic. All 6 cases were associatedPublication Metadata only Point-of-care lung ultrasound for the detection of pulmonary manifestations of malaria and sepsis: An observational study(2018-12-01) Stije J. Leopold; Aniruddha Ghose; Katherine A. Plewes; Subash Mazumder; Luigi Pisani; Hugh W.F. Kingston; Sujat Paul; Anupam Barua; M. Abdus Sattar; Michaëla A.M. Huson; Andrew P. Walden; Patricia C. Henwood; Elisabeth D. Riviello; Marcus J. Schultz; Nicholas P.J. Day; Asok Kumar Dutta; Nicholas J. White; Arjen M. Dondorp; Brigham and Women's Hospital; Mahidol University; Chittagong Medical College Hospital; Nuffield Department of Clinical Medicine; Royal Berkshire Hospital; Harvard Medical School; Amsterdam UMC - University of Amsterdam-constrained hospital setting. LUS was highly feasible and allowed to accurately identify patients at risk of death in a resource limited setting.... are credited. Introduction Patients with severe malaria or sepsis are at risk of developing life-threatening acute respiratory distress syndrome (ARDS). The objective of this study was to evaluate point-of-care lung ultrasound as a novel tool to determinePublication Metadata only Risk factors for typhoid fever in the Mekong delta, southern Viet Nam: A case-control study(2001-01-01) Christine Luxemburger; Chau Minh Duc; Mai Ngoc Lanh; John Wain; Tran Tinh Hien; Julie A. Simpson; Le Hoang Kam; Nguyen Thi Tu Thuy; Nicholas J. White; Jeremy J. Farrar; Centre for Tropical Diseases Vietnam; Nuffield Department of Clinical Medicine; Provincial Hospital of Dong Thap; Mahidol University; John Radcliffe HospitalIn order to identify risk factors for typhoid fever in a highly endemic area, we undertook a case-control study in the Mekong delta, Viet Nam. Cases were 144 consecutive patients admitted to hospital with blood culture-confirmed typhoid fever. Two... controls (1 in the hospital and 1 in the community) were chosen for each case. Standardized interviews were conducted with questions regarding recent contact with a typhoid fever patient, eating habits, hygiene and socio-economic level. Cases were morePublication Metadata only Central venous catheter use in severe malaria: Time to reconsider the World Health Organization guidelines?(2011-11-17) Josh Hanson; Sophia Wk Lam; Sanjib Mohanty; Shamshul Alam; Md Mahtab Hasan; Sue J. Lee; Marcus J. Schultz; Prakaykaew Charunwatthana; Sophie Cohen; Ashraf Kabir; Saroj Mishra; Nicholas Pj Day; Nicholas J. White; Arjen M. Dondorp; Cairns Base Hospital; Mahidol University; Ispat General Hospital; Chittagong Medical College Hospital; Academic Medical Centre, University of Amsterdam; Cox's Bazar Medical College; Nuffield Department of Clinical MedicineBackground: To optimize the fluid status of adult patients with severe malaria, World Health Organization (WHO) guidelines recommend the insertion of a central venous catheter (CVC) and a target central venous pressure (CVP) of 0-5 cmH 2 O. However... there are few data from clinical trials to support this recommendation. Methods. Twenty-eight adult Indian and Bangladeshi patients admitted to the intensive care unit with severe falciparum malaria were enrolled in the study. All patients had a CVC insertedPublication Metadata only A comparison of chloramphenicol, trimethoprim-sulfamethoxazole, and doxycycline with doxycycline alone as maintenance therapy for melioidosis(1999-01-01) Wipada Chaowagul; Andrew J.H. Simpson; Yupin Suputtamongkol; Michael D. Smith; Brian J. Angus; Nicholas J. White; Sappasitthiprasong Hospital; Mahidol University; Centre for Tropical Medicine; John Radcliffe Hospital; Musgrove Park Hospitalin oral maintenance treatment of melioidosis. Adult Thai patients with culture-confirmed melioidosis were randomized to receive treatment with either regimen for a minimum of 12 weeks, usually following intravenous treatment of severe disease. The main... outcome measure was culture-confirmed relapse. One hundred sixteen patients were enrolled; 109 had culture-confirmed melioidosis, and 87 were considered evaluable (43 had received doxycycline). Culture-confirmed relapse occurred in one patient randomizedPublication Metadata only A double-blind placebo-controlled study of an infusion of lexipafant (platelet-activating factor receptor antagonist) in patients with severe sepsis(2000-03-01) Yupin Suputtamongkol; Sunanta Intaranongpai; Michael D. Smith; Brian Angus; Wipada Chaowagul; Chairat Permpikul; Julie A. Simpson; Amorn Leelarasamee; Lloyd Curtis; Nicholas J. White; Mahidol University; Nuffield Department of Clinical Medicine; Sappasitthiprasong Hospital; British Bio-technology Ltd.; Surin Hospital; Taunton Hospitalwith 131 adult Thai patients with suspected severe sepsis (66 of whom had positive blood cultures). Detailed serial clinical, biochemical, and cytokine measurements were performed. Lexipafant treatment was well tolerated. The 28-day mortality