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Publication Metadata only Artesunate-atovaquone-proguanil rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: A preliminary report(2003-09-01) Rose McGready; Napaporn Khan Keo; Leopoldo Villegas; Nicholas J. White; Sornchai Looareesuwan; François Nosten; Shoklo Malaria Research Unit; Mahidol University; Churchill Hospital; Instituto de Altos Estudios en Salud PúblicaPregnant women are particularly vulnerable to malaria infections. Multidrug resistance in Plasmodium falciparum seriously compromises treatment in some endemic areas. Between April 1999 and October 2001, we treated and prospectively followed 27... for pregnant women exposed to multidrug- resistant P. falciparum malaria.Publication Metadata only Treatment of uncomplicated multidrug-resistant falciparum malaria with artesunate-atovaquone-proguanil(2002-12-15) Michèle Van Vugt; Elisabetta Leonardi; Lucy Phaipun; Thra Slight; Kyaw Lay Thway; Rose McGready; Alan Brockman; Leopoldo Villegas; Sornchai Looareesuwan; Nicholas J. White; Franc̃ois Nosten; Shoklo Malaria Research Unit; Mahidol University; Slotervaart Hospital; John Radcliffe HospitalIn an open-label trial carried out on the northwest border of Thailand, 1596 patients with uncomplicated multidrug-resistant falciparum malaria were randomly assigned to receive atovaquone-proguanil, atovaquone-proguanil-artesunate, or artesunate..., but after day 2, dizziness, sleep disturbance, nausea, vomiting, and anorexia were more common among mefloquine recipients (P ≤ .014). Artesunate-atovaquone-proguanil is a highly effective and well-tolerated treatment for multidrug-resistant falciparumPublication Metadata only Short course of ofloxacin for treatment of multidrug-resistant typhoid(1995-01-01) Tran Tinh Hien; Delia B. Bethell; Nguyen Thi Tuyet Hoa; John Wain; To Song Diep; Le Thi Phi; Bui Minh Cuong; Nguyen Minh Duong; Pham Thi Thanh; Amanda L. Walsh; Nicholas P.J. Day; Nicholas J. White; Centre for Tropical Diseases Vietnam; The Hospital for Children; John Radcliffe Hospital; Mahidol Universitybecause of their reported toxicity in the cartilage of experimental animals. In a paired, open, randomized study during an epidemic of multidrug-resistant typhoid in southern Vietnam, two short-course ofloxacin regimens (15 mg/kg daily for 3 days and 10 mg... course of ofloxacin proved to be safe and highly effective in the treatment of uncomplicated, multidrug-resistant typhoid fever. © 1995 by The University of Chicago. All rights reserved.Publication Metadata only Mefloquine for multidrug-resistant malaria(1991-11-16) Christine Luxemburger; Francois Nosten; Feiko Ter Kuiile; Luc Frejacques; Tan Chongsuphajaisiddhi; Nicholas J. White; Medecins Sans Frontieres; Mahidol University; University of AmsterdamPublication Metadata only Randomized, controlled dose-optimization studies of dihydroartemisinin- piperaquine for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand(2004-11-15) Elizabeth A. Ashley; Srivicha Krudsood; Lucy Phaiphun; Siripan Srivilairit; Rose McGready; Wattana Leowattana; Robert Hutagalung; Polrat Wilairatana; Alan Brockman; Sornchai Looareesuwan; François Nosten; Nicholas J. White; Shoklo Malaria Research Unit; Mahidol University; Churchill Hospital; Menzies School of Health Researchthe level in most artemisinin-containing combinations. This raised the possibility that the efficacy of the current coformulation may not be optimal in the treatment of multidrug-resistant falciparum malaria. Methods. In 2 large randomized, controlled... of multidrug-resistant falciparum malaria, and its efficacy is not improved by the addition of more DHA.Publication Metadata only Artesunate and mefloquine in the treatment of uncomplicated multidrug-resistant hyperparasitaemic falciparum malaria(1998-01-01) Ric Price; Christine Luxemburger; Michele Van Vugt; François Nosten; Am Kham; Julie Simpson; Sornchai Looareesuwan; Tan Chongsuphajaisiddhi; Nicholas J. White; Shoklo Malaria Research Unit; Mahidol University; St George's University of London; University of Amsterdam; John Radcliffe Hospital, together with mefloquine (25 mg/kg) given on day 2, is an effective treatment for uncomplicated hyperparasitaemic falciparum malaria in this area of high level multidrug resistance....Oral artesunate is the most effective treatment for uncomplicated hyperparasitaemia in falciparum malaria. To assess the contribution of mefloquine to therapeutic efficacy in an area endemic for mefloquine-resistant Plasmodium falciparum, an openPublication Metadata only Artemisinin antimalarials in pregnancy: A prospective treatment study of 539 episodes of multidrug-resistant Plasmodium falciparum(2001-12-15) Rose McGready; Thein Cho; Napaporn Khan Keo; Kyaw Lay Kyaw Lay Thwai; Leopoldo Villegas; Sornchai Looareesuwan; Nicholas J. White; François Nosten; Shoklo Malaria Research Unit; Mahidol University; John Radcliffe Hospital; Instituto de Altos Estudios en Salud PúblicaThe emergence and spread of multidrug-resistant Plasmodium falciparum compromises the treatment of malaria, especially during pregnancy, where the choice of antimalarials is already limited. Artesunate (n = 528) or artemether (n = 11) was usedPublication Metadata only A randomized, controlled study of a simple, once-daily regimen of dihydroartemisinin-piperaquine for the treatment of uncomplicated, multidrug-resistant falciparum malaria(2005-08-15) Elizabeth A. Ashley; Rose McGready; Robert Hutagalung; Lucy Phaiphun; Thra Slight; Stephane Proux; Kyaw Lay Thwai; Marion Barends; Sornchai Looareesuwan; Nicholas J. White; François Nosten; Shoklo Malaria Research Unit; Mahidol University; Churchill Hospitalin the DP4 group (P = .05 vs. the MAS3 group). Conclusions. A once-daily, 3-dose regimen of DP is a highly efficacious treatment for multidrug-resistant falciparum malaria. This simple, safe, and relatively inexpensive fixed combination could becomePublication Metadata only An open label randomized comparison of mefloquine-artesunate as separate tablets vs. a new co-formulated combination for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand(2006-11-01) Elizabeth A. Ashley; Khin Maung Lwin; Rose McGready; Win Htay Simon; Lucy Phaiphun; Stephane Proux; Nantawan Wangseang; Walter Taylor; Kasia Stepniewska; Wimon Nawamaneerat; Kyaw Lay Thwai; Marion Barends; Wattana Leowattana; Piero Olliaro; Pratap Singhasivanon; Nicholas J. White; François Nosten; Shoklo Malaria Research Unit; Mahidol University; Churchill Hospital; Organisation Mondiale de la Santeof separate tablets for the treatment of uncomplicated multidrug-resistant falciparum malaria. Methods: On the north-western border of Thailand 500 adults and children with uncomplicated falciparum malaria were randomized to receive either the new fixed... and spread of drug resistant strains of Plasmodium falciparum. A lower tablet burden should also facilitate adherence to treatment. A new fixed combination of mefloquine plus artesunate has been developed. This was compared with the conventional regimenPublication Metadata only Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number(2004-07-31) Ric N. Price; Anne Catrin Uhlemann; Alan Brockman; Rose McGready; Elizabeth Ashley; Lucy Phaipun; Rina Patel; Kenneth Laing; Sornchai Looareesuwan; Nicholas J. White; François Nosten; Sanjeev Krishna; St George's University of London; John Radcliffe Hospital; Shoklo Malaria Research Unit; Menzies School of Health Research; Mahidol UniversityBackground The borders of Thailand harbour the world's most multidrug resistant Plasmodium falciparum parasites. In 1984 mefloquine was introduced as treatment for uncomplicated falciparum malaria, but substantial resistance developed within 6 years.... A combination of artesunate with mefloquine now cures more than 95% of acute infections. For both treatment regimens, the underlying mechanisms of resistance are not known. Methods The relation between polymorphisms in the P falciparum multidrug