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Publication Metadata only An immunohistochemical study of the pathology of fatal malaria: Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration(1994-11-01) Gareth D.H. Turner; Heather Morrison; Margaret Jones; Timothy M.E. Davis; Sornchai Looareesuwan; Ian D. Buley; Kevin C. Gatter; Christopher I. Newbold; Sasithon Pukritayakamee; Bussarin Nagachinta; Nicholas J. White; Anthony R. Berendt; John Radcliffe Hospital; Mahidol University; Polpaholpayuhasena Hospital; University of Western Australia-1 and E-selectin expression on vessels in the brain. In contrast, cerebral endothelial CD36 and thrombospondin staining were sparse, with no evidence for increased expression in malaria. There was highly significant co-localization of sequestration... with the expression of ICAM-1, CD36, and E-selectin in cerebral vessels but no cellular inflammatory response. These results suggest that these receptors have a role in sequestration in vivo and indicate that systemic endothelial activation is a feature of fatalPublication Metadata only Short report: Reversibility of retinal microvascular changes in severe falciparum malaria(2014-01-01) Richard J. Maude; Hugh W.F. Kingston; Sonia Joshi; Sanjib Mohanty; Saroj K. Mishra; Nicholas J. White; Arjen M. Dondorp; Mahidol University; Ispat General Hospitalprominent retinal whitening with corresponding retinal microvascular obstruction, vessel dilatation, increased vascular tortuosity, and blood retinal barrier leakage with decreased visual acuity, all of which resolved on recovery. Additional studyPublication Metadata only Reduced microcirculatory flow in severe falciparum malaria: Pathophysiology and electron-microscopic pathology(2004-01-01) Arjen M. Dondorp; Emsri Pongponratn; Nicholas J. White; Mahidol University; John Radcliffe Hospitalvessels. Besides, parasitized red cells become rigid, compromising their flow through capillaries whose lumen has been reduced by sequestered erythrocytes. Adhesive forces between infected red cells (auto-agglutination), between infected and uninfected redPublication Metadata only Effects of malaria heme products on red blood cell deformability(2007-10-01) Forradee Nuchsongsin; Kesinee Chotivanich; Prakaykaew Charunwatthana; Omodeo Salè Fausta; Donatella Taramelli; Nicholas P. Day; Nicholas J. White; Arjen M. Dondorp; Mahidol University; Universita degli Studi di MilanoIn falciparum malaria, the deformability of the entire erythrocyte population is reduced in proportion to disease severity, and this compromises microcirculatory blood flow through vessels partially obstructed by cytoadherent parasitizedPublication Metadata only Induction of the vascular endothelial growth factor pathway in the brain of adults with fatal falciparum malaria is a non-specific response to severe disease(2010-08-01) Isabelle M. Medana; Nicholas P J Day; Rachel Roberts; Navakanit Sachanonta; Helen Turley; Emsri Pongponratn; Tran Tinh Hien; Nicholas J. White; Gareth D H Turner; John Radcliffe Hospital; Churchill Hospital; Mahidol University; Cho Quan Hospitalmalaria, but DEC-1, which is more stable and regulated by HIF-1, was observed. There was heterogeneous expression of VEGF and its receptors in severe malaria and non-malarial disease controls. pKDR expression on vessels was greater in malaria cases thanPublication Metadata only The eye in cerebral malaria: what can it teach us?(2009-07-01) Richard J. Maude; Arjen M. Dondorp; Abdullah Abu Sayeed; Nicholas P.J. Day; Nicholas J. White; Nicholas A.V. Beare; Mahidol University; John Radcliffe Hospital; Chittagong Medical College Hospital; Royal Liverpool and Broadgreen University Hospitals NHS Trustthe hypothesis that the sequestration of erythrocytes in small blood vessels and consequent obstruction of microcirculatory flow is an important mechanism causing coma and death in CM. Despite advances in the antimalarial treatment of severe malaria, itsPublication Metadata only A quantitative analysis of the microvascular sequestration of malaria parasites in the human brain(1999-01-01) Kamolrat Silamut; Nguyen H. Phu; Christopher Whitty; Gareth D.H. Turner; Karina Louwrier; Nguyen T.H. Mai; Julie A. Simpson; Tran T. Hien; Nicholas J. White; Mahidol University; Cho Quan Hospital(range) ratio of cerebral to peripheral blood parasitemia was 40 (1.8 to 1500). Within the same brain different vessels had discrete but different populations of parasites, indicating that the adhesion characteristics of cerebrovascular endothelium changePublication Metadata only A review of the spectrum of clinical ocular fundus findings in P. falciparum malaria in African children with a proposed classification and grading system(1999-01-01) Susan Lewallen; Simon P. Harding; Jeff Ajewole; W. Edmund Schulenburg; Malcolm E. Molyneux; Kevin Marsh; Stanley Usen; Nicholas J. White; Terrie E. Taylor; The University of British Columbia; Royal Liverpool and Broadgreen University Hospitals NHS Trust; National Eye Care Project; Western Eye Hospital; University of Malawi College of Medicine; University of Liverpool; Kenya Medical Research Institute; Medical Research Council Laboratories Gambia; Mahidol University; Michigan State Universityand The Gambia by direct and indirect ophthalmoscopy with dilated pupils, we have determined that the 5 distinct clinical features (in order of frequency) include retinal whitening, haemorrhages, unique vessel abnormalities, papilloedema, and cotton wool spotsPublication Metadata only Coma in fatal adult human malaria is not caused by cerebral oedema(2011-09-21) Isabelle M. Medana; Nicholas Pj Day; Navakanit Sachanonta; Nguyen Th Mai; Arjen M. Dondorp; Emsri Pongponratn; Tran T. Hien; Nicholas J. White; Gareth Dh Turner; University of Oxford; Nuffield Department of Clinical Medicine; Mahidol University; UCLsequestration and resultant microvascular congestion in cerebral vessels. To determine whether these changes cause breakdown of the blood-brain barrier and resultant perivascular or parenchymal cerebral oedema, histology, immunohistochemistry and image analysisPublication Metadata only A quantitative ultrastructural study of renal pathology in fatal Plasmodium falciparum malaria(2007-09-01) Sudarat Nguansangiam; Nicholas P J Day; Tran Tinh Hien; Nguyen Thi Hoang Mai; Urai Chaisri; Mario Riganti; Arjen M. Dondorp; Sue J. Lee; Nguyen Hoan Phu; Gareth D H Turner; Nicholas J. White; David J P Ferguson; Emsri Pongponratn; Mahidol University; Vajira Hospital; Nuffield Department of Clinical Medicine; Cho Quan Hospitalfeatures included PRBC sequestration in glomerular and tubulo-interstitial vessels, acute tubular damage and mild glomerular hypercellularity resulting from the accumulation of host monocytes within glomerular capillaries. No evidence for an immune complex