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Author: Paulus F.

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    Association of intraoperative end-tidal CO2 levels with postoperative outcomes: a patient-level analysis of two randomised clinical trials
    (2025-01-01) Nasa P.; van Meenen D.M.P.; Paulus F.; Ferrando C.; Bluth T.; Gama de Abreu M.; Ball L.; Bossers S.M.; Schober P.; Schultz M.J.; Serpa Neto A.; Hemmes S.N.T.; Campos N.S.; Bluth T.; Hemmes S.N.T.; Librero J.; Pozo N.; Ferrando C.; Ball L.; Mazzinari G.; Pelosi P.; Gama de Abreu M.; Schultz M.J.; Neto A.S.; Hemmes S.N.T.; Gama de Abreu M.; Severgnini P.; Hollmann M.W.; Binnekade J.M.; Wrigge H.; Canet J.; Hiesmayr M.; Schmid W.; Tschernko E.; Jaber S.; Hedenstierna G.; Putensen C.; Pelosi P.; Schultz M.J.; Marti A.; Bacuzzi A.; Brodhun A.; Molin A.; Merten A.; Parera A.; Brunelli A.; Cortegiani A.; Güldner A.; Reske A.W.; Gratarola A.; Giarratano A.; Bastin B.; Heyse B.; Mazul-Sunko B.; Amantea B.; Barberis B.; Putensen C.; Uhlig C.; Marín C.M.; Celentano C.; La Bella D.; D'Antini D.; Velghe D.; Sulemanji D.; De Robertis E.; Hartmann E.; Montalto F.; Tropea F.; Mills G.H.; Cinnella G.; Della Rocca G.; Caggianelli G.; Pellerano G.; Mollica G.; Bugedo G.; Wrigge H.; Mulier J.P.; Vandenbrande J.; Geib J.; Yaqub J.; Florez J.; Mayoral J.F.; Sprung J.; Van Limmen J.; Bos L.D.J.; de Baerdemaeker L.; Jamaer L.; Spagnolo L.; Strys L.; Gil M.G.; Gama de Abreu M.; Vidal Melo M.F.; Schultz M.J.; Unzueta M.C.; Moral M.V.; Ferner M.; Hollmann M.W.; Weiss M.; Vanoni M.; Schaefer M.S.; Nasa P.; Mahidol University
    Background: The relationship between intraoperative end-tidal CO2 (etCO2) levels and postoperative outcomes remains unclear. We conducted a post hoc analysis of two randomised trials in adults undergoing major surgery under... general anaesthesia. Methods: We re-analysed individual participant data comparing high or low positive end-expiratory pressure with low tidal volume intraoperative ventilation using a merged database derived from two randomised trials in non-obese
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    Associations of intraoperative end–tidal CO2 levels with postoperative outcome–secondary analysis of a worldwide observational study
    (2025-02-01) Nasa P.; van Meenen D.M.P.; Paulus F.; de Abreu M.G.; Bossers S.M.; Schober P.; Schultz M.J.; Neto A.S.; Hemmes S.N.T.; Kroell W.; Metzler H.; Struber G.; Wegscheider T.; Gombotz H.; Hiesmayr M.; Schmid W.; Urbanek B.; Kahn D.; Momeni M.; Pospiech A.; Lois F.; Forget P.; Grosu I.; Poelaert J.; van Mossevelde V.; van Malderen M.C.; Dylst D.; van Melkebeek J.; Beran M.; de Hert S.; De Baerdemaeker L.; Heyse B.; Van Limmen J.; Wyffels P.; Jacobs T.; Roels N.; De Bruyne A.; van de Velde S.; Leva B.; Damster S.; Plichon B.; JurosZovko M.; Djonovic-Omanoviċ D.; Pernar S.; Zunic J.; Miskovic P.; Zilic A.; Kvolik S.; Ivic D.; Azenic-Venzera D.; Skiljic S.; Vinkovic H.; Oputric I.; Juricic K.; Frkovic V.; Kopic J.; Mirkovic I.; Karanovic N.; Carev M.; Dropulic N.; Saric J.P.; Erceg G.; Dvorscak M.B.; Mazul-Sunko B.; Pavicic A.M.; Goranovic T.; Maldini B.; Radocaj T.; Gavranovic Z.; Mladic-Batinica I.; Sehovic M.; Stourac P.; Harazim H.; Smekalova O.; Kosinova M.; Kolacek T.; Hudacek K.; Drab M.; Brujevic J.; Vitkova K.; Jirmanova K.; Volfova I.; Dzurnakova P.; Liskova K.; Dudas R.; Filipsky R.; El Kafrawy S.; Abdelwahab H.H.; Metwally T.; Abdel-Razek A.; El-Shaarawy A.M.; Hasan W.F.; Ahmed A.G.; Yassin H.; Magdy M.; Abdelhady M.; Mahran M.; Herodes E.; Kivik P.; Oganjan J.; Nasa P.; Mahidol University
    Background: Patients receiving intraoperative ventilation during general anesthesia often have low end–tidal CO2 (etCO2). We examined the association of intraoperative etCO2 levels with the occurrence of postoperative pulmonary complications (PPCs...) in a conveniently–sized international, prospective study named ‘Local ASsessment of Ventilatory management during General Anesthesia for Surgery’ (LAS VEGAS). Methods: Patients at high risk of PPCs were categorized as ‘low etCO2’ or ‘normal to high etCO
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    Brain protective ventilation in acute brain injury patients with use of fully automated ventilation (BRAVE): A cross-over clinical trial
    (2025-01-01) Goossen R.L.; Gavinelli S.; Dragoni S.; Van Meenen D.M.P.; Paulus F.; Schultz M.J.S.; Ball L.; Patroniti N.A.; Robba C.; Goossen R.L.; Mahidol University
    carbon dioxide (EtCO2), peripheral oxygen saturation (SpO2), tidal volume (VT), and maximum airway pressures (Pmax). RESULTS A total of 20 patients were included. With automated ventilation the proportion [range] of breaths within the optimal zone... ventilation. MAIN OUTCOME MEASURE The primary endpoint was the percentage of breaths in three predefined zones of ventilatory targets, defined as optimal, acceptable and critical. The zones were based on patient-specific ranges of four measures: end-tidal