4 results
Search Results
Now showing 1 - 4 of 4
Publication Metadata only Effects of sevuparin on rosette formation and cytoadherence of Plasmodium falciparum infected erythrocytes(2017-03-01) Somporn Saiwaew; Juntima Sritabal; Nattaporn Piaraksa; Srisuda Keayarsa; Ronnatrai Ruengweerayut; Chirapong Utaisin; Patima Sila; Rangsan Niramis; Rachanee Udomsangpetch; Prakaykaew Charunwatthana; Emsri Pongponratn; Sasithon Pukrittayakamee; Anna M. Leitgeb; Mats Wahlgren; Sue J. Lee; Nicholas P.J. Day; Nicholas J. White; Arjen M. Dondorp; Kesinee Chotivanich; Mahidol University; Mae Sot General Hospital; Mae Ramat Hospital; Queen Sirikit National Institute of Child Health; Dilaforette AB; Karolinska University Hospital; Nuffield Department of Clinical Medicineare credited. In severe falciparum malaria cytoadherence of parasitised red blood cells (PRBCs) to vascular endothelium (causing sequestration) and to uninfected red cells (causing rosette formation) contribute to microcirculatory flow obstruction in vital... been eliminated, substantially diminishing its anticoagulant activity. Sevuparin has been evaluated recently in patients with uncomplicated falciparum malaria, and is currently investigated in a clinical trial for sickle cell disease. The effectsPublication Open Access Rapid clinical assessment to facilitate the triage of adults with falciparum malaria, a retrospective analysis.(2014-01-29) Hanson, Josh; Lee, Sue J.; Mohanty, Sanjib; Faiz, M. Abul; Anstey, Nicholas M.; Price, Ric N.; Prakaykaew Charunwatthana; ประกายแก้ว จรูญวรรธนะ; Yunus, Emran Bin; Mishra, Saroj K.; Tjitra, Emiliana; Ridwanur Rahman; Francois Nosten; Htut, Ye; Maude, Richard J.; Chau, Tran Thi Hong; Phu, Nguyen Hoan; Hien, Tran Tinh; White, Nicholas J.; Day, Nicholas P. J.; Dondorp, Arjen M.; Hanson, Josh; Mahidol University. Faculty of Tropical Medicine. Mahidol Oxford Tropical Medicine Research Unit.BACKGROUND: Most adults dying from falciparum malaria will die within 48 hours of their hospitalisation. An essential component of early supportive care is the rapid identification of patients at greatest risk. In resource-poor settings, where most patients with falciparum malaria are managed, decisions regarding patient care must frequently be made using clinical evaluation alone. METHODS: We retrospectively analysed 4 studies of 1801 adults with severe falciparum malaria to determine whether the presence of simple clinical findings might assist patient triage. RESULTS: If present on admission, shock, oligo-anuria, hypo- or hyperglycaemia, an increased respiratory rate, a decreased Glasgow Coma Score and an absence of fever were independently predictive of death. The variables were used to construct a simple clinical algorithm. When applied to the 1801 patients, this algorithm's positive predictive value for survival to 48 hours was 99.4 (95% confidence interval (CI) 97.8-99.9) and for survival to discharge 96.9% (95% CI 94.3-98.5). In the 712 patients receiving artesunate, the algorithm's positive predictive value for survival to 48 hours was 100% (95% CI 97.3-100) and to discharge was 98.5% (95% CI 94.8-99.8). CONCLUSIONS: Simple clinical findings are closely linked to the pathophysiology of severe falciparum malaria in adults. A basic algorithm employing these indices can facilitate the triage of patients in settings where intensive care services are limited. Patients classified as low-risk by this algorithm can be safely managed initially on a general ward whilst awaiting senior clinical review and laboratory data.Publication Open Access Correlation of biomarkers for parasite burden and immune activation with acute kidney injury in severe falciparum malaria(2014) Katherine Plewes; Royakkers, Annick A; Josh Hanson; Md Mahtab Uddin Hasan; Shamsul Alam; Aniruddha Ghose; Maude, Richard J; Stassen, Pauline M; Prakaykaew Charunwatthana; Lee, Sue J; Turner, Gareth DH; Dondorp, Arjen M; Schultz, Marcus J; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research UnitBackground: Acute kidney injury (AKI) complicating severe Plasmodium falciparum malaria occurs in up to 40% of adult patients. The case fatality rate reaches 75% in the absence of renal replacement therapy (RRT). The precise pathophysiology of AKIPublication Open Access Central venous catheter use in severe malaria: time to reconsider the World Health Organization guidelines?(2011-11-14) Hanson, Josh; Lam, Sophia WK; Mohanty, Sanjib; Alam, Shamshul; Hasan, Md Mahtab Uddin; Lee, Sue J; Schultz, Marcus J; Prakaykaew Charunwatthana; ประกายแก้ว จรูญวรรธนะ; Cohen, Sophie; Kabir, Ashraf; Mishra, Saroj; Day, Nicholas PJ; White, Nicholas J; Dondorp, Arjen M; Hanson, Josh; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit.and had regular CVP measurements recorded. The CVP measurements were compared with markers of disease severity, clinical endpoints and volumetric measures derived from transpulmonary thermodilution. RESULTS: There was no correlation between... the admission CVP and patient outcome (p = 0.67) or disease severity (p = 0.33). There was no correlation between the baseline CVP and the concomitant extravascular lung water (p = 0.62), global end diastolic volume (p = 0.88) or cardiac index (p = 0