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Author: Punsawad C.

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Now showing 1 - 6 of 6
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    Antimalarial efficacy and toxicological assessment of medicinal plant ingredients of Prabchompoothaweep remedy as a candidate for antimalarial drug development
    (2023-12-01) Chaniad P.; Techarang T.; Phuwajaroanpong A.; Plirat W.; Viriyavejakul P.; Septama A.W.; Punsawad C.; Mahidol University
    to explore potent medicinal plants from Prabchompoothaweep remedy for antimalarial drug development. Methods: Forty-eight crude extracts from Prabchompoothaweep remedy and its 23 plants ingredients were investigated in vitro for antimalarial properties using... Plasmodium lactate dehydrogenase (pLDH) enzyme against Plasmodium falciparum K1 strain and toxicity effects were evaluated in Vero cells. The plant with promising antimalarial activity was further investigated using gas chromatography-mass spectrometry (GC-MS
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    Preclinical evaluation of antimalarial activity of CPF-1 formulation as an alternative choice for the treatment of malaria
    (2023-12-01) Chaniad P.; Techarang T.; Phuwajaroanpong A.; Plirat W.; Na-Ek P.; Konyanee A.; Viriyavejakul P.; Septama A.W.; Punsawad C.; Mahidol University
    LDH) assay. Cytotoxicity in Vero and HepG2 cells was assessed using the MTT assay. An extract with good antimalarial potency and selectivity index (SI) was selected for in vivo antimalarial activity using Peter’s 4-day suppressive test and acute oral toxicity... that was selected to confirm its in vivo antimalarial activity and toxicity. The results demonstrated a significant dose-dependent reduction in parasitemia. Maximum suppressive effect of the extract (72.01%) was observed at the highest dose administered (600 mg/kg
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    Antiplasmodial activity and cytotoxicity of plant extracts from the Asteraceae and Rubiaceae families
    (2022-01-01) Chaniad P.; Phuwajaroanpong A.; Techarang T.; Viriyavejakul P.; Chukaew A.; Punsawad C.; Mahidol University
    . flava and the leaf extract of B. balsamifera had strong antimalarial properties with minimal toxicity, indicating that compounds from these plant species have the potential to be developed into new antiplasmodial agents.... antimalarial drug. Therefore, this study aimed to evaluate the in vitro antimalarial activity and cytotoxicity of extracts from plants belonging to the Asteraceae and Rubiaceae families. The phytoconstituents of one hundred ten ethanolic and aqueous extracts
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    Exploring the potential antimalarial properties, safety profile, and phytochemical composition of Mesua ferrea Linn.
    (2024-12-01) Konyanee A.; Chaniad P.; Phuwajaroanpong A.; Plirat W.; Viriyavejakul P.; Septama A.W.; Punsawad C.; Konyanee A.; Mahidol University
    medicinal plant, as a source for novel antimalarial compounds. In this study, we conducted in vitro assays to evaluate the antimalarial activity and cytotoxicity of crude extracts derived from M. ferrea L. leaves and branches. Subsequently, the most... promising extracts were subjected to assessments of their antimalarial efficacy and acute oral toxicity tests in mouse models. Furthermore, selected crude extracts underwent gas chromatography-mass spectrometry (GC-MS) analysis to identify
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    Unveiling the Antimalarial Potential of Leaf Extracts of Mussaenda erythrophylla Schum. & Thonn. and Mussaenda philippica Dona Luz x M. flava in Mice
    (2026-01-01) Chaniad P.; Phuwajaroanpong A.; Plirat W.; Konyanee A.; Viriyavejakul P.; Septama A.W.; Punsawad C.; Chaniad P.; Mahidol University
    of novel and affordable antimalarial compounds for drug development. This study aimed to evaluate the antimalarial potential and acute oral toxicity of ethanolic leaf extract of Mussaenda erythrophylla Schum. & Thonn. (M. erythrophylla or Dona Trining...Malaria remains a major global public health concern, particularly in tropical regions. The increasing resistance to the current antimalarial drugs highlights the urgent need for new and effective therapies. Medicinal plants offer a promising source
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    Rhinacanthins from Rhinacanthus nasutus inhibit the Plasmodium falciparum mitochondrial cytochrome bc1 complex revealed by chemical genetic and in silico studies
    (2026-08-01) Sunghanghwa Y.; Prommana P.; Yap B.K.; Rattanajak R.; Shaw P.J.; Suksawat T.; Shah M.A.; Punsawad C.; Panichayupakaranant P.; Kongkasuriyachai D.; Kamchonwongpaisan S.; Jaisi A.; Sunghanghwa Y.; Mahidol University
    Malaria remains a major global health challenge, worsened by drug-resistant Plasmodium falciparum . Natural products remain key sources for novel therapeutics. Rhinacanthus nasutus , a Southeast Asian medicinal plant, produces rhinacanthins... . Roots of R. nasutus were extracted to yield rhinacanthins -B, -C, -D, and -N. In vitro activity was assessed against P. falciparum 3D7 and atovaquone-resistant strains using SYBR Green I assay. Cytotoxicity was determined in Vero and KB cells via