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Author: S. Looareesuwan

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    A comparative clinical trial of combinations of dihydroartemisinin plus azithromycin and dihydroartemisinin plus mefloquine for treatment of multidrug resistant falciparum malaria
    (2002-12-01) S. Krudsood; K. Buchachart; K. Chalermrut; C. Charusabha; S. Treeprasertsuk; O. Haoharn; C. Duangdee; S. Looareesuwan; Mahidol University
    With the deteriorating situation of multidrug resistant falciparum malaria, a new drug or drugs in combinations are urgently needed. We conducted a study comparing a combination of dihydroartemisinin 240 mg and mefloquine 1,250 mg given over 3 days... and azithromycin was safe and effective and may be another interesting regimen of the treatment of uncomplicated multidrug resistant Plasmodium falciparum malaria in Thailand.
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    Therapeutic responses to quinine and clindamycin in multidrug-resistant falciparum malaria
    (2000-09-06) S. Pukrittayakamee; A. Chantra; S. Vanijanonta; R. Clemens; S. Looareesuwan; N. J. White; Mahidol University
    Therapeutic responses to clindamycin in combination with quinine were assessed in adult Thai patients with uncomplicated multidrug-resistant Plasmodium falciparum malaria. In total 204 patients were randomized to receive a 7-day oral treatment...% for the Q7-only regimen (P ≤ 0.04). Clindamycin in combination with quinine is a safe and effective treatment for multidrug-resistant P. falciparum malaria. This combination may be of particular value in children and pregnant women, in whom tetracyclines
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    Efficacy of six doses of artemether-lumefantrine (benflumetol) in multidrug-resistant Plasmodium falciparum malaria
    (1999-06-01) M. Van Vugt; P. Wilairatana; B. Gemperli; I. Gathmann; L. Phaipun; A. Brockman; C. Luxemburger; N. J. White; F. Nosten; S. Looareesuwan; Shoklo Malaria Research Unit; Mahidol University; Novartis International AG
    of artemether and 1,920 mg of lumefantrine) in a double-blind trial involving 359 patients with uncomplicated multidrug-resistant falciparum malaria. There were no differences between the three treatment groups in parasite and fever clearance times, and reported... well-tolerated treatment for multidrug-resistant falciparum malaria.
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    Clinical trial of artesunate and artemether on multidrug resistant falciparum malaria in Thailand. A preliminary report
    (1991-12-01) D. Bunnag; C. Viravan; S. Looareesuwan; J. Karbwang; T. Harinasuta; Mahidol University
    A 5-day course of oral artesunate at total doses of 1200, 600, 650 mg and intramuscular artemether 480 mg proved effective (90-100% cured) in the treatment of multidrug resistant falciparum malaria in Thailand. Shorter courses yielded high
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    Randomized comparison of artemether-benflumetol and artesunate- mefloquine in treatment of multidrug-resistant falciparum malaria
    (1998-01-01) M. Van Vugt; A. Brockman; B. Gemperli; C. Luxemburger; I. Gathmann; C. Royce; Thra Slight; S. Looareesuwan; N. J. White; F. Nosten; Shoklo Malaria Research Unit; Academic Medical Centre, University of Amsterdam; Mahidol University; Novartis International AG; John Radcliffe Hospital
    An open, randomized comparison of artemether-benflumetol (CGP 56 697; Novartis) with artesunate-mefloquine was conducted in 617 patients with acute uncomplicated multidrug-resistant falciparum malaria on the western border of Thailand. Both... and four times more common in the artesunate-mefloquine group than in the artemether- benflumetol group (P < 0.001). Artemether-benflumetol is effective and very well tolerated in the treatment of multidrug-resistant falciparum malaria. A higher dose than
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    A case-control auditory evaluation of patients treated with artemisinin derivatives for multidrug-resistant Plasmodium falciparum malaria
    (2000-01-01) M. Van Vugt; B. J. Angus; R. N. Price; C. Mann; J. A. Simpson; C. Poletto; Saw Eh Htoo; S. Looareesuwan; N. J. White; F. Nosten; Shoklo Malaria Research Unit; Academic Medical Centre, University of Amsterdam; Mahidol University; John Radcliffe Hospital; Southern General Hospital Glasgow; Charing Cross Hospital
    The artemisinin derivatives are now used widely in areas with multidrug- resistant Plasmodium falciparum malaria such as Southeast Asia, but concerns remain over their potential for neurotoxicity. Mice, rats, dogs, and monkeys treated with high
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    Artemether-lumefantrine for the treatment of multidrug-resistant falciparum malaria
    (2000-01-01) M. Van Vugt; S. Looareesuwan; P. Wilairatana; R. McGready; L. Villegas; I. Gathmann; R. Mull; A. Brockman; N. J. White; F. Nosten; Shoklo Malaria Research Unit; Academic Medical Centre, University of Amsterdam; Mahidol University; Ministry of Health; Novartis International AG; John Radcliffe Hospital
    %) for artesunate-mefloquine. The 6-dose regimen of artemether-lumefantrine was better tolerated than, and as effective as, artesunate-mefloquine, the current standard treatment in this area of multidrug-resistant P. falciparum malaria.
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    Drug resistant malaria, with special reference to Thailand
    (1992-12-01) S. Looareesuwan; T. Harinasuta; T. Chongsuphajaisiddhi; Mahidol University
    Drug resistance of malaria parasites is a major problem confronting efforts to treat and control malaria. Starting with chloroquine, the emergence of resistance to other drugs has led to multidrug resistance patterns that pose increasing threats... for the future. This report reviews work carried out over the past decades at the Hospital for Tropical Diseases, Bangkok, which monitors patients from many areas, including the Thai-Cambodian border, which harbors the world's most severe multi-drug resistant
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    The rational use of qinghaosu and its derivatives : What is the future of new compounds ?
    (1998-12-01) S. Looareesuwan; Mahidol University
    In Thailand, artesunate and artemether are the mainly used antimalarials for treatment of severe or multidrug resistant falciparum malaria. However, their availability (supply) and the registration requirements are the major limitations
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    Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: A prospective study
    (2000-07-22) F. Nosten; M. Van Vugt; R. Price; C. Luxemburger; K. L. Thway; A. Brockman; R. McGready; F. Ter Kuile; S. Looareesuwan; N. J. White; Shoklo Malaria Research Unit; Mahidol University; Academic Medical Centre, University of Amsterdam; John Radcliffe Hospital; Centers for Disease Control and Prevention
    Background. Worsening drug resistance in Plasmodium falciparum malaria is a major threat to health in tropical countries. We did a prospective study of malaria incidence and treatment in an area of highly multidrug-resistant P falciparum malaria... (cure rate with mefloquine [15 mg/kg] and sulphadoxine-pyrimethamine in 1985, 98% [95% CI 97-100]), but as mefloquine resistance developed. the cure rate fell (71% [67-77] in 1990). A similar pattern was seen for high-dose (25 mg/kg) mefloquine