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Author: Schultz M.J.

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Now showing 1 - 5 of 5
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    Association of intraoperative end-tidal CO2 levels with postoperative outcomes: a patient-level analysis of two randomised clinical trials
    (2025-01-01) Nasa P.; van Meenen D.M.P.; Paulus F.; Ferrando C.; Bluth T.; Gama de Abreu M.; Ball L.; Bossers S.M.; Schober P.; Schultz M.J.; Serpa Neto A.; Hemmes S.N.T.; Campos N.S.; Bluth T.; Hemmes S.N.T.; Librero J.; Pozo N.; Ferrando C.; Ball L.; Mazzinari G.; Pelosi P.; Gama de Abreu M.; Schultz M.J.; Neto A.S.; Hemmes S.N.T.; Gama de Abreu M.; Severgnini P.; Hollmann M.W.; Binnekade J.M.; Wrigge H.; Canet J.; Hiesmayr M.; Schmid W.; Tschernko E.; Jaber S.; Hedenstierna G.; Putensen C.; Pelosi P.; Schultz M.J.; Marti A.; Bacuzzi A.; Brodhun A.; Molin A.; Merten A.; Parera A.; Brunelli A.; Cortegiani A.; Güldner A.; Reske A.W.; Gratarola A.; Giarratano A.; Bastin B.; Heyse B.; Mazul-Sunko B.; Amantea B.; Barberis B.; Putensen C.; Uhlig C.; Marín C.M.; Celentano C.; La Bella D.; D'Antini D.; Velghe D.; Sulemanji D.; De Robertis E.; Hartmann E.; Montalto F.; Tropea F.; Mills G.H.; Cinnella G.; Della Rocca G.; Caggianelli G.; Pellerano G.; Mollica G.; Bugedo G.; Wrigge H.; Mulier J.P.; Vandenbrande J.; Geib J.; Yaqub J.; Florez J.; Mayoral J.F.; Sprung J.; Van Limmen J.; Bos L.D.J.; de Baerdemaeker L.; Jamaer L.; Spagnolo L.; Strys L.; Gil M.G.; Gama de Abreu M.; Vidal Melo M.F.; Schultz M.J.; Unzueta M.C.; Moral M.V.; Ferner M.; Hollmann M.W.; Weiss M.; Vanoni M.; Schaefer M.S.; Nasa P.; Mahidol University
    Background: The relationship between intraoperative end-tidal CO2 (etCO2) levels and postoperative outcomes remains unclear. We conducted a post hoc analysis of two randomised trials in adults undergoing major surgery under... general anaesthesia. Methods: We re-analysed individual participant data comparing high or low positive end-expiratory pressure with low tidal volume intraoperative ventilation using a merged database derived from two randomised trials in non-obese
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    Associations of intraoperative end–tidal CO2 levels with postoperative outcome–secondary analysis of a worldwide observational study
    (2025-02-01) Nasa P.; van Meenen D.M.P.; Paulus F.; de Abreu M.G.; Bossers S.M.; Schober P.; Schultz M.J.; Neto A.S.; Hemmes S.N.T.; Kroell W.; Metzler H.; Struber G.; Wegscheider T.; Gombotz H.; Hiesmayr M.; Schmid W.; Urbanek B.; Kahn D.; Momeni M.; Pospiech A.; Lois F.; Forget P.; Grosu I.; Poelaert J.; van Mossevelde V.; van Malderen M.C.; Dylst D.; van Melkebeek J.; Beran M.; de Hert S.; De Baerdemaeker L.; Heyse B.; Van Limmen J.; Wyffels P.; Jacobs T.; Roels N.; De Bruyne A.; van de Velde S.; Leva B.; Damster S.; Plichon B.; JurosZovko M.; Djonovic-Omanoviċ D.; Pernar S.; Zunic J.; Miskovic P.; Zilic A.; Kvolik S.; Ivic D.; Azenic-Venzera D.; Skiljic S.; Vinkovic H.; Oputric I.; Juricic K.; Frkovic V.; Kopic J.; Mirkovic I.; Karanovic N.; Carev M.; Dropulic N.; Saric J.P.; Erceg G.; Dvorscak M.B.; Mazul-Sunko B.; Pavicic A.M.; Goranovic T.; Maldini B.; Radocaj T.; Gavranovic Z.; Mladic-Batinica I.; Sehovic M.; Stourac P.; Harazim H.; Smekalova O.; Kosinova M.; Kolacek T.; Hudacek K.; Drab M.; Brujevic J.; Vitkova K.; Jirmanova K.; Volfova I.; Dzurnakova P.; Liskova K.; Dudas R.; Filipsky R.; El Kafrawy S.; Abdelwahab H.H.; Metwally T.; Abdel-Razek A.; El-Shaarawy A.M.; Hasan W.F.; Ahmed A.G.; Yassin H.; Magdy M.; Abdelhady M.; Mahran M.; Herodes E.; Kivik P.; Oganjan J.; Nasa P.; Mahidol University
    Background: Patients receiving intraoperative ventilation during general anesthesia often have low end–tidal CO2 (etCO2). We examined the association of intraoperative etCO2 levels with the occurrence of postoperative pulmonary complications (PPCs...) in a conveniently–sized international, prospective study named ‘Local ASsessment of Ventilatory management during General Anesthesia for Surgery’ (LAS VEGAS). Methods: Patients at high risk of PPCs were categorized as ‘low etCO2’ or ‘normal to high etCO
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    Closed-Loop ventilation using sidestream versus mainstream capnography for automated adjustments of minute ventilation-A randomized clinical trial in cardiac surgery patients
    (2023-01-01) Nijbroek S.G.L.H.; Roozeman J.P.; Ettayeby S.; Rosenberg N.M.; van Meenen D.M.P.; Cherpanath T.G.V.; Lagrand W.K.; Tepaske R.; Klautz R.J.M.; Neto A.S.; Schultz M.J.; Mahidol University
    BACKGROUND: INTELLiVENT-Adaptive Support Ventilation (ASV) is a closed-loop ventilation mode that uses capnography to adjust tidal volume (VT) and respiratory rate according to a user-set end-tidal CO2 (etCO2) target range. We compared sidestream... based on the measured VT, maximum airway pressure, etCO2 and pulse oximetry. The primary outcome was the proportion of breaths spent in a predefined 'optimal' zone of ventilation during the first three hours of postoperative ventilation, with a non
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    Brain Protective Ventilation Strategies in Severe Acute Brain Injury
    (2025-10-13) Sharie S.A.; Almari R.; Azzam S.; Al-Husinat L.; Araydah M.; Battaglini D.; Schultz M.J.; Patroniti N.A.; Rocco P.R.M.; Robba C.; Sharie S.A.; Mahidol University
    targets over ventilator modes, judicious use of positive end-expiratory pressure (PEEP) with concurrent cerebral monitoring, limiting plateau pressures, and maintaining tidal volumes within protective ranges. Minimizing driving pressure (ΔP) and mechanical... power (MP) is emphasized to reduce the risk of ventilator-induced lung injury (VILI). The review underscores the importance of precise control of arterial carbon dioxide (PaCO₂) to regulate cerebral blood flow, avoidance of both hypoxemia and hyperoxia