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Item Metadata only Clinical characteristics, physiological features, and outcomes associated with hypercapnia in patients with acute hypoxemic respiratory failure due to COVID–19—-insights from the PRoVENT–COVID study(2022-06-01) Tsonas A.M.; Botta M.; Horn J.; Morales-Quinteros L.; Artigas A.; Schultz M.J.; Paulus F.; Neto A.S.; Mahidol Universityrates, higher driving pressures, and with more mechanical power of ventilation. Hypercapnic patients had comparable minute volumes but higher ventilatory ratios than normocapnic patients. In hypercapnic patients, ventilation and LOS in ICU and hospital...Purpose: We determined the incidence of hypercapnia and associations with outcome in invasively ventilated COVID–19 patients. Methods: Posthoc analysis of a national, multicenter, observational study in 22 ICUs. Patients were classifiedItem Metadata only Effect of a low versus intermediate tidal volume strategy on pulmonary complications in patients at risk of acute respiratory distress syndrome—a randomized clinical trial(2023-01-01) de Haro C.; Neto A.S.; Gomà G.; González M.E.; Ortega A.; Forteza C.; Frutos-Vivar F.; García R.; Simonis F.D.; Gordo-Vidal F.; Suarez D.; Schultz M.J.; Artigas A.; Mahidol Universityin the intensive care units of 10 hospitals in Spain and one in the United States of America (USA) from 3 November 2014 to 30 August 2016. Patients were randomized to invasive ventilation using low VT (≤ 6 mL/kg predicted body weight, PBW) (N = 50) or intermediate... of intensive care unit (ICU) and hospital stay; and ICU, hospital, 28– and 90–day mortality. Results: In total, 98 patients [67.3% male], with a median age of 65.5 years [interquartile range 55–73], were enrolled until the study was prematurely stopped becauseItem Metadata only Early acute kidney injury is associated with in-hospital adverse outcomes in critically ill burn patients: an observational study(2023-08-31) Martins J.; Nin N.; Muriel A.; Peñuelas Ó.; Vasco D.; Vaquero P.; Schultz M.J.; Lorente J.A.; Mahidol UniversityBACKGROUND: There are no studies in large series of burn patients on the relationship between acute kidney injury (AKI) and adverse outcomes using the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. METHODS: We retrospectively analysed... data from a cohort of burn patients admitted to the intensive care unit (ICU) with the diagnosis of burn injury. The diagnosis of AKI over the first 7 days after injury was made according to the KDIGO guidelines. The primary outcome was ICU mortalityItem Metadata only Hyperoxemia in invasively ventilated COVID–19 patients–Insights from the PRoVENT–COVID study(2022-01-01) Tsonas A.M.; van Meenen D.M.; Botta M.; Shrestha G.S.; Roca O.; Paulus F.; Neto A.S.; Schultz M.J.; Mahidol University, and mortality in ICU, hospital, and at day 28 and 90. We used propensity matching to control for observed confounding factors that may influence endpoints. Results: Of 851 COVID–19 patients, 225 (26.4%) were classified as hyperoxemic. Excessive oxygen use...Objective: We determined the prevalences of hyperoxemia and excessive oxygen use, and the epidemiology, ventilation characteristics and outcomes associated with hyperoxemia in invasively ventilated patients with coronavirus disease 2019 (COVID–19Item Metadata only Clinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study(2024-01-01) Robba C.; Battaglini D.; Abbas A.; Sarrió E.; Cinotti R.; Asehnoune K.; Taccone F.S.; Rocco P.R.; Schultz M.J.; Citerio G.; Stevens R.D.; Badenes R.; Robba C.; Mahidol Universityinjured (ABI) patients and assess the occurrence of abnormal PaCO2 values during the first week in the intensive care unit (ICU). The secondary aim was to assess the association of PaCO2 with in-hospital mortality. Methods: We carried out a secondary... hypocapnia and hypercapnia were used in 40 (2.7%) and 173 (11.7%) patients. PaCO2 had a U-shape relationship with in-hospital mortality with only severe hypocapnia and hypercapnia being associated with increased probability of in-hospital mortality (omnibus pItem Metadata only Impact of Country Income Level on Outcomes in Patients with Acute Brain Injury Requiring Invasive Mechanical Ventilation: A Secondary Analysis of the ENIO Study(2025-01-01) Feng S.N.; Diaz-Cruz C.; Cinotti R.; Asehnoune K.; Schultz M.J.; Shrestha G.S.; Sanches P.R.; Robba C.; Cho S.M.; Feng S.N.; Mahidol University− 7.82 to − 3.36), and 1.96 times the odds of hospital mortality (p = 0.011, 95% CI 1.17–3.30). Conclusions: In an international registry of patients with ABI requiring invasive mechanical ventilation, MICs had higher odds of ICU mortality...Background: Invasive mechanical ventilation can present complex challenges for patients with acute brain injury (ABI) in middle-income countries (MICs). We characterized the impact of country income level on weaning strategies and outcomesItem Metadata only Personalized mechanical ventilation guided by ultrasound in patients with acute respiratory distress syndrome (PEGASUS): study protocol for an international randomized clinical trial(2024-12-01) Sinnige J.S.; Smit M.R.; Ghose A.; de Grooth H.J.; Itenov T.S.; Ischaki E.; Laffey J.; Paulus F.; Póvoa P.; Pierrakos C.; Pisani L.; Roca O.; Schultz M.J.; Szuldrzynski K.; Tuinman P.R.; Zimatore C.; Bos L.D.J.; Sinnige J.S.; Mahidol Universityto better target mechanical ventilation strategies of individual patients. However, classifying morphology through chest radiography or computed tomography is either inaccurate or impractical. Lung ultrasound (LUS) is a non-invasive bedside tool that can... accurately distinguish “focal” from “non-focal” lung morphology. We hypothesize that LUS-guided personalized mechanical ventilation in ARDS patients leads to a reduction in 90-day mortality compared to conventional mechanical ventilation. MethodsItem Metadata only Association of Noninvasive Respiratory Support with Extubation Outcomes in Brain-injured Patients Receiving Mechanical Ventilation: A Secondary Analysis of the ENIO Prospective Observational Study(2023-08-01) Taran S.; Diaz-Cruz C.; Perrot B.; Alvarez P.; Godoy D.A.; Gurjar M.; Haenggi M.; Mijangos J.C.; Pelosi P.; Robba C.; Schultz M.J.; Ueno Y.; Asehnoune K.; Cho S.M.; Yarnell C.J.; Cinotti R.; Stevens R.D.; Mahidol Universitywith patient-level covariates and random intercepts for hospital and country to evaluate the association between prophylactic (i.e., planned) HFNC or NIPPV and reintubation. Measurements and Main Results: 1,115 patients were included from 62 hospitals and 19...Rationale: Noninvasive respiratory support using a high-flow nasal cannula (HFNC) or noninvasive positive pressure ventilation (NIPPV) can decrease the risk of reintubation in patients being liberated from mechanical ventilation, but effectsItem Metadata only Epidemiology, ventilation management and outcomes of COVID–19 ARDS patients versus patients with ARDS due to pneumonia in the Pre–COVID era(2024-12-01) van der Ven F.L.I.M.; Blok S.G.; Azevedo L.C.; Bellani G.; Botta M.; Estenssoro E.; Fan E.; Ferreira J.C.; Laffey J.G.; Martin–Loeches I.; Motos A.; Pham T.; Peñuelas O.; Pesenti A.; Pisani L.; Neto A.S.; Schultz M.J.; Torres A.; Tsonas A.M.; Paulus F.; van Meenen D.M.P.; van der Ven F.L.I.M.; Mahidol UniversityBackground: Ventilation management may differ between COVID–19 ARDS (COVID–ARDS) patients and patients with pre–COVID ARDS (CLASSIC–ARDS); it is uncertain whether associations of ventilation management with outcomes for CLASSIC–ARDS also exist... in COVID–ARDS. Methods: Individual patient data analysis of COVID–ARDS and CLASSIC–ARDS patients in six observational studies of ventilation, four in the COVID–19 pandemic and two pre–pandemic. Descriptive statistics were used to compare epidemiologyItem Metadata only Sedation Practices in Mechanically Ventilated Neurocritical Care Patients from 19 Countries: An International Cohort Study(2025-01-01) Feng S.N.; Laws L.H.; Diaz-Cruz C.; Cinotti R.; Schultz M.J.; Asehnoune K.; Stevens R.D.; Robba C.; Cho S.M.; Feng S.N.; Mahidol UniversityBackground: Our objective was to characterize the impact of common initial sedation practices on invasive mechanical ventilation (IMV) duration and in-hospital outcomes in patients with acute brain injury (ABI) and to elucidate variations... in practices between high-income and middle-income countries. Methods: This was a post hoc analysis of a prospective observational data registry of neurocritically ill patients requiring IMV. The setting included 73 intensive care units (ICUs) in 18 countries