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Item Metadata only Association of Noninvasive Respiratory Support with Extubation Outcomes in Brain-injured Patients Receiving Mechanical Ventilation: A Secondary Analysis of the ENIO Prospective Observational Study(2023-08-01) Taran S.; Diaz-Cruz C.; Perrot B.; Alvarez P.; Godoy D.A.; Gurjar M.; Haenggi M.; Mijangos J.C.; Pelosi P.; Robba C.; Schultz M.J.; Ueno Y.; Asehnoune K.; Cho S.M.; Yarnell C.J.; Cinotti R.; Stevens R.D.; Mahidol Universitysecondary analysis of a prospective, observational study of mechanically ventilated patients with ABI (clinicaltrials.gov identifier NCT03400904). The primary endpoint was reintubation during ICU admission. We used mixed-effects logistic regression modelsItem Metadata only Erratum: Correction: Clinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study (Intensive care medicine (2024) 50 2 (234-246))(2024-02-01) Robba C.; Battaglini D.; Abbas A.; Sarrió E.; Cinotti R.; Asehnoune K.; Taccone F.S.; Rocco P.R.; Schultz M.J.; Citerio G.; Stevens R.D.; Badenes R.; Robba C.; Mahidol UniversityItem Metadata only Impact of Country Income Level on Outcomes in Patients with Acute Brain Injury Requiring Invasive Mechanical Ventilation: A Secondary Analysis of the ENIO Study(2025-01-01) Feng S.N.; Diaz-Cruz C.; Cinotti R.; Asehnoune K.; Schultz M.J.; Shrestha G.S.; Sanches P.R.; Robba C.; Cho S.M.; Feng S.N.; Mahidol Universityin patients with ABI. Methods: A secondary analysis was performed on a registry of critically ill patients with ABI admitted to 73 intensive care units (ICUs) in 18 countries from 2018 to 2020. Patients were classified as high-income country (HIC) or MIC.... The primary outcome was ICU mortality. Secondary outcomes were days to first extubation, tracheostomy, extubation failure, ICU length of stay, and hospital mortality. Multivariable analyses were adjusted for clinically preselected covariates such as age, sexItem Metadata only Clinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study(2024-01-01) Robba C.; Battaglini D.; Abbas A.; Sarrió E.; Cinotti R.; Asehnoune K.; Taccone F.S.; Rocco P.R.; Schultz M.J.; Citerio G.; Stevens R.D.; Badenes R.; Robba C.; Mahidol Universityinjured (ABI) patients and assess the occurrence of abnormal PaCO2 values during the first week in the intensive care unit (ICU). The secondary aim was to assess the association of PaCO2 with in-hospital mortality. Methods: We carried out a secondaryItem Metadata only Authors reply: “Associations of positive end-expiratory pressure (PEEP) with extubation failure and clinical outcomes in invasively ventilated patients with acute brain injury: A secondary analysis of the ENIO study”(2026-08-01) Battaglini D.; Cinotti R.; Asehnoune K.; Loggini A.; Montagnani L.; Ball L.; Gualdi F.; Rocco P.R.M.; Schultz M.J.; Patroniti N.A.; Robba C.; Battaglini D.; Mahidol UniversityItem Metadata only Authors reply: “Associations of positive end-expiratory pressure (PEEP) with extubation failure and clinical outcomes in invasively ventilated patients with acute brain injury: A secondary analysis of the ENIO study”(2026-06-01) Battaglini D.; Cinotti R.; Asehnoune K.; Loggini A.; Montagnani L.; Ball L.; Gualdi F.; Rocco P.R.M.; Schultz M.J.; Patroniti N.A.; Robba C.; Battaglini D.; Mahidol UniversityItem Metadata only Authors reply: “Associations of positive end-expiratory pressure (PEEP) with extubation failure and clinical outcomes in invasively ventilated patients with acute brain injury: A secondary analysis of the ENIO study”(2026-06-01) Battaglini D.; Cinotti R.; Asehnoune K.; Loggini A.; Montagnani L.; Ball L.; Gualdi F.; Rocco P.R.M.; Schultz M.J.; Patroniti N.A.; Robba C.; Battaglini D.; Mahidol UniversityItem Metadata only Associations of positive end-expiratory pressure (PEEP) with extubation failure and clinical outcomes in invasively ventilated patients with acute brain injury: A secondary analysis of the ENIO study(2026-02-01) Battaglini D.; Cinotti R.; Asehnoune K.; Loggini A.; Montagnani L.; Ball L.; Gualdi F.; Rocco P.R.M.; Schultz M.J.; Patroniti N.A.; Robba C.; Battaglini D.; Mahidol UniversityBackground: Invasive mechanical ventilation (IMV) is crucial for managing acute brain injury (ABI) patients, yet the effects of positive end-expiratory pressure (PEEP) on outcomes are not well understood. This study aimed to evaluate the relationship between PEEP levels and risk of extubation failure as well as intensive care unit (ICU) mortality in ABI patients. Methods: This post-hoc analysis of the ENIO study included 1512 ABI patients from the ENIO cohort, excluding those without available data on PEEP at day 1 and who never received an extubation trial. PEEP levels were recorded at days 1, 3, 7, and on the day of extubation. Logistic regression assessed the association between PEEP and extubation failure, while Cox proportional hazards regression analyzed ICU mortality. Results: Among 1154 included patients, extubation failure occurred in 21.2 % and ICU mortality was 3.7 %. Higher median PEEP at days 1, 3, and 7 was independently associated with increased odds ratio (OR) of extubation failure (OR = 1.13; 95 %CI = 1.01–1.26; p = 0.0294). At the time of extubation, higher PEEP was also significantly associated with extubation failure (OR = 1.13; 95 %CI = 1.02–1.25; p = 0.0218) and ICU mortality (Hazard Ratio, HR = 1.38; 95 %CI = 1.12–1.69; p = 0.0026). However, at sensitivity analyses adjusted for acute respiratory distress syndrome (ARDS), PEEP was no longer significantly associated with outcomes, while ARDS itself was an independent predictor of extubation failure. Conclusions: Extubating ABI patients at higher PEEP levels was associated with an increased risk of extubation failure and ICU mortality. However, this association likely reflects underlying respiratory pathology or disease severity. Our findings suggest that PEEP level may serve as a surrogate marker for extubation readiness, rather than a modifiable risk factor, and highlight the need for individualized assessment prior to extubation.Item Metadata only Personalized mechanical ventilation guided by ultrasound in patients with acute respiratory distress syndrome (PEGASUS): study protocol for an international randomized clinical trial(2024-12-01) Sinnige J.S.; Smit M.R.; Ghose A.; de Grooth H.J.; Itenov T.S.; Ischaki E.; Laffey J.; Paulus F.; Póvoa P.; Pierrakos C.; Pisani L.; Roca O.; Schultz M.J.; Szuldrzynski K.; Tuinman P.R.; Zimatore C.; Bos L.D.J.; Sinnige J.S.; Mahidol Universityfor “focal” ARDS. The primary endpoint is all-cause mortality at day 90. Secondary outcomes are mortality at day 28, ventilator-free days at day 28, ICU length of stay, ICU mortality, hospital length of stay, hospital mortality, and number of complicationsItem Metadata only Clinical characteristics, physiological features, and outcomes associated with hypercapnia in patients with acute hypoxemic respiratory failure due to COVID–19—-insights from the PRoVENT–COVID study(2022-06-01) Tsonas A.M.; Botta M.; Horn J.; Morales-Quinteros L.; Artigas A.; Schultz M.J.; Paulus F.; Neto A.S.; Mahidol Universityas ‘hypercapnic’ or ‘normocapnic’ in the first three days of invasive ventilation. Primary endpoint was prevalence of hypercapnia. Secondary endpoints were ventilator parameters, length of stay (LOS) in ICU and hospital, and mortality in ICU, hospital, at day 28
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