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Item Open Access Transepidermal water loss of the diseased skin : evidence summary and clinical applications(Mahidol University, 2023) Chutima Seree-Aphinan; Kumutnart Chanprapaph; Poonkiat Suchonwanit; Kunlawat Thadaniponbeen most extensively studied in atopic dermatitis; its TEWL values were consistently higher than normal controls and correlated with skin barrier disruption. TEWL estimates in other diseases followed distinctive trends, with most inflammatory diseases... controls (e.g., scleroderma, leprosy, diabetic neuropathy). Hence, TEWL estimates of non-atopic skin may reflect derangements of other TEWL-regulating structures in addition to skin barrier disruption. For clinical utilities, TEWL measurements can be used